Patents by Inventor Travis Stiles

Travis Stiles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF PROMOTING CNS NEURONAL REPAIR BY INHIBITING LRP-1
    Publication number: 20210284708
    Abstract: This invention provides methods for promoting and/or restoring neurite outgrowth and neuronal regeneration by contacting an injured neuron with an inhibitor of low density lipoprotein receptor-related protein-1 (LRP-1).
    Type: Application
    Filed: November 5, 2020
    Publication date: September 16, 2021
    Applicant: The J. David Gladstone Institutes
    Inventors: Steven L. Gonias, Travis Stiles, Alban Gaultier, Wendy M. Campana, Katerina Akassoglou
  • METHODS AND COMPOSITIONS FOR PROMOTING OPC DIFFERENTIATION AND REMYELINATION USING RECEPTOR ASSOCIATED PROTEIN (RAP)
    Publication number: 20200397857
    Abstract: The present disclosure relates to methods and compositions using RAP, a derivative of RAP, a variant of RAP, or a fragment of RAP to inhibit LRP1, a myelin debris receptor. The methods and compositions involve increasing, promoting, restoring, and/or enhancing differentiation of oligodendrocyte progenitor cells, myelin protein expression, mature oligodendrocyte marker expression, and/or myelination. The methods and compositions disclosed herein inhibit or block pathological activation of RhoA in OPCs. The methods and compositions also involve alleviating one or more symptoms of MS and treating MS, including slowing or stopping MS progression.
    Type: Application
    Filed: May 5, 2020
    Publication date: December 24, 2020
    Inventor: Travis STILES
  • Methods of promoting CNS neuronal repair by inhibiting LRP-1
    Patent number: 10829536
    Abstract: This invention provides methods for promoting and/or restoring neurite outgrowth and neuronal regeneration by contacting an injured neuron with an inhibitor of low density lipoprotein receptor-related protein-1 (LRP-1).
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: November 10, 2020
    Assignee: The Regents of the University of California
    Inventors: Steven L. Gonias, Travis Stiles, Alban Gaultier, Wendy M. Campana, Katerina Akassoglou
  • METHODS OF PROMOTING CNS NEURONAL REPAIR BY INHIBITING LRP-1
    Publication number: 20190284254
    Abstract: This invention provides methods for promoting and/or restoring neurite outgrowth and neuronal regeneration by contacting an injured neuron with an inhibitor of low density lipoprotein receptor-related protein-1 (LRP-1).
    Type: Application
    Filed: June 22, 2016
    Publication date: September 19, 2019
    Applicant: The J. David Gladstone Institutes
    Inventors: Steven L. Gonias, Travis Stiles, Alban Gaultier, Wendy M. Campana, Katerina Akassoglou
  • METHODS AND COMPOSITIONS FOR PROMOTING OPC DIFFERENTIATION AND REMYELINATION USING RECEPTOR ASSOCIATED PROTEIN (RAP)
    Publication number: 20190083571
    Abstract: The present disclosure relates to methods and compositions using RAP, a derivative of RAP, a variant of RAP, or a fragment of RAP to inhibit LRP1, a myelin debris receptor. The methods and compositions involve increasing, promoting, restoring, and/or enhancing differentiation of oligodendrocyte progenitor cells, myelin protein expression, mature oligodendrocyte marker expression, and/or myelination. The methods and compositions disclosed herein inhibit or block pathological activation of RhoA in OPCs. The methods and compositions also involve alleviating one or more symptoms of MS and treating MS, including slowing or stopping MS progression.
    Type: Application
    Filed: September 21, 2018
    Publication date: March 21, 2019
    Inventor: Travis Stiles
  • Methods of promoting CNS neuronal repair by inhibiting LRP-1
    Patent number: 9376481
    Abstract: This invention provides methods for promoting and/or restoring neurite outgrowth and neuronal regeneration by contacting an injured neuron with an inhibitor of low density lipoprotein receptor-related protein-1 (LRP-1).
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: June 28, 2016
    Assignees: The Regents of the University of California, J. David Gladsone Institutes
    Inventors: Steven L. Gonias, Travis Stiles, Alban Gaultier, Wendy M. Campana, Katerina Akassoglou
  • METHODS OF PROMOTING CNS NEURONAL REPAIR BY INHIBITING LRP-1
    Publication number: 20140161807
    Abstract: This invention provides methods for promoting and/or restoring neurite outgrowth and neuronal regeneration by contacting an injured neuron with an inhibitor of low density lipoprotein receptor-related protein-1 (LRP-1).
    Type: Application
    Filed: April 26, 2012
    Publication date: June 12, 2014
    Applicant: The Regents of The University of California
    Inventors: Steven L. Gonias, Travis Stiles, Alban Gaultier, Wendy M. Campana, Katerina Akassoglou