Patents by Inventor Trent Gu

Trent Gu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF REVERSE TRANSCRIPTION
    Publication number: 20090137020
    Abstract: The present invention relates to reverse transcription of RNA, and in particular to reverse transcription by thermostable DNA polymerases. Thermoactinomyces vulgaris and Bacillus stearothermophilus possess reverse transcriptase activity in the presence of magnesium or manganese ions. Methods, compositions, and kits for reverse transcription and RT-PCR are also provided.
    Type: Application
    Filed: January 20, 2009
    Publication date: May 28, 2009
    Applicant: PROMEGA CORPORATION
    Inventors: Trent Gu, Fen Huang, James Robert Hartnett
  • Method of reverse transcription
    Patent number: 7504220
    Abstract: The present invention relates to reverse transcription of RNA, and in particular to reverse transcription by thermostable DNA polymerases. Thermoactinomyces vulgaris and Bacillus stearothermophilus possess reverse transcriptase activity in the presence of magnesium or manganese ions. Methods, compositions, and kits for reverse transcription and RT-PCR are also provided.
    Type: Grant
    Filed: June 27, 2006
    Date of Patent: March 17, 2009
    Assignee: Promega Corporation
    Inventors: Trent Gu, Fen Huang, James Robert Hartnett
  • Thermophilic DNA polymerases from thermoactinomyces vulgaris
    Publication number: 20070172879
    Abstract: The present invention provides compositions comprising thermostable DNA polymerases derived from hyperthermophilic eubacteria. In particular, the present invention comprises thermostable DNA polymerases from the hyperthermophilic eubacterial species Thermoactinomyces vulgaris. The present invention also provides methods for utilizing naturally-occurring and non-naturally-occurring forms of T. vulgaris DNA polymerase in sequencing, reverse transcription, and amplification reactions.
    Type: Application
    Filed: March 19, 2007
    Publication date: July 26, 2007
    Inventors: Trent Gu, Fen Huang, James Hartnett
  • Thermophilic DNA polymerases from
    Patent number: 7214522
    Abstract: The present invention provides compositions comprising thermostable DNA polymerases derived from hyperthermophilic eubacteria. In particular, the present invention comprises thermostable DNA polymerases from the hyperthermophilic eubacterial species Thermoactinomyces vulgaris. The present invention also provides methods for utilizing naturally-occurring and non-naturally-occurring forms of T. vulgaris DNA polymerase in sequencing, reverse transcription, and amplification reactions.
    Type: Grant
    Filed: May 23, 2003
    Date of Patent: May 8, 2007
    Assignee: Promega Corporation
    Inventors: Trent Gu, Fen Huang, James Robert Hartnett
  • THERMOPHILIC DNA POLYMERASES FROM THERMOACTINOMYCES VULGARIS
    Publication number: 20070082333
    Abstract: The present invention provides compositions comprising thermostable DNA polymerases derived from hyperthermophilic eubacteria. In particular, the present invention comprises thermostable DNA polymerases from the hyperthermophilic eubacterial species Thermoactinomyces vulgaris. The present invention also provides methods for utilizing naturally-occurring and non-naturally-occurring forms of T. vulgaris DNA polymerase in sequencing, reverse transcription, and amplification reactions.
    Type: Application
    Filed: May 23, 2003
    Publication date: April 12, 2007
    Inventors: Trent Gu, Fen Huang, James Hartnett
  • Method of reverse transcription
    Publication number: 20060240468
    Abstract: The present invention relates to reverse transcription of RNA, and in particular to reverse transcription by thermostable DNA polymerases. Thermoactinomyces vulgaris and Bacillus stearothermophilus possess reverse transcriptase activity in the presence of magnesium or manganese ions. Methods, compositions, and kits for reverse transcription and RT-PCR are also provided.
    Type: Application
    Filed: June 27, 2006
    Publication date: October 26, 2006
    Inventors: Trent Gu, Fen Huang, James Hartnett
  • reverse transcription compositions and kits
    Patent number: 7094539
    Abstract: The present invention relates to reverse transcription of RNA, and in particular to reverse transcription by thermostable DNA polymerases. Thermoactinomyces vulgaris and Bacillus stearothermophilus possess reverse transcriptase activity in the presence of magnesium or manganese ions. Methods, compositions, and kits for reverse transcription and RT-PCR are also provided.
    Type: Grant
    Filed: June 24, 2002
    Date of Patent: August 22, 2006
    Assignee: Promega Corporation
    Inventors: Trent Gu, Fen Huang, James Robert Hartnett
  • Detection of nucleic acid hybrids
    Publication number: 20050214753
    Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of a predetermined nucleic acid. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, speciation, determination of viral load, genotyping, medical marker diagnostics, and the like.
    Type: Application
    Filed: February 22, 2001
    Publication date: September 29, 2005
    Applicant: Promega Corporation
    Inventors: John Shultz, Martin Lewis, Donna Leippe, Michelle Mandrekar, Daniel Kephart, Richard Rhodes, Christine Andrews, James Hartnett, Trent Gu, Ryan Olson, Keith Wood, Roy Welch
  • Detection of nucleic acid hybrids
    Patent number: 6730479
    Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of a predetermined nucleic acid. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, speciation, determination of viral load, genotyping, medical marker diagnostics, and the like.
    Type: Grant
    Filed: February 22, 2001
    Date of Patent: May 4, 2004
    Assignee: Promega Corporation
    Inventors: John William Shultz, Martin K. Lewis, Donna Leippe, Michelle Mandrekar, Daniel Kephart, Richard Byron Rhodes, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Ryan J. Olson, Keith V. Wood, Roy Welch
  • Multiplex method for nucleic acid detection
    Patent number: 6653078
    Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of predetermined nucleic acid target sequences using a multiplex assay format. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, speciation, genotyping, medical marker diagnostics, and the like.
    Type: Grant
    Filed: February 20, 2001
    Date of Patent: November 25, 2003
    Assignee: Promega Corporation
    Inventors: Martin K. Lewis, Daniel Kephart, Richard Byron Rhodes, John William Shultz, Donna Leippe, Michelle Mandrekar, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Keith V. Wood, Roy Welch
  • Exogenous nucleic acid detection
    Publication number: 20030203358
    Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of a predetermined exogenous nucleic acid. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, determination of viral load, genotyping, medical marker diagnostics, and the like.
    Type: Application
    Filed: February 9, 2001
    Publication date: October 30, 2003
    Applicant: Promega Corporation
    Inventors: John William Shultz, Martin K. Lewis, Donna Leippe, Michelle Mandrekar, Daniel Kephart, Richard Byron Rhodes, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Ryan J. Olson, Keith V. Wood, Roy Welch
  • Multiplex method for nucleic acid detection
    Publication number: 20030194699
    Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of predetermined nucleic acid target sequences using a multiplex assay format. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, speciation, genotyping, medical marker diagnostics, and the like.
    Type: Application
    Filed: February 20, 2001
    Publication date: October 16, 2003
    Applicant: Promega Corporation
    Inventors: Martin K. Lewis, Daniel Kephart, Richard Byron Rhodes, John William Shultz, Donna Leippe, Michelle Mandrekar, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Keith V. Wood, Roy Welch
  • Thermophilic DNA polymerases from Thermoactinomyces vulgaris
    Patent number: 6632645
    Abstract: The present invention provides compositions comprising thermostable DNA polymerases derived from hyperthermophilic eubacteria. In particular, the present invention comprises thermostable DNA polymerases from the hyperthermophilic eubacterial species Thermoactinomyces vulgaris. The present invention also provides methods for utilizing naturally-occurring and non-naturally-occurring forms of T. vulgaris DNA polymerase in sequencing, reverse transcription, and amplification reactions.
    Type: Grant
    Filed: March 2, 2000
    Date of Patent: October 14, 2003
    Assignee: Promega Corporation
    Inventors: Trent Gu, Fen Huang, James Robert Hartnett
  • Method of reverse transcription
    Publication number: 20030180737
    Abstract: The present invention relates to reverse transcription of RNA, and in particular to reverse transcription by thermostable DNA polymerases. Thermoactinoinyces vulgaris and Bacillus stearothermophilus possess reverse transcriptase activity in the presence of magnesium or manganese ions. Methods, compositions, and kits for reverse transcription and RT-PCR are also provided.
    Type: Application
    Filed: June 24, 2002
    Publication date: September 25, 2003
    Inventors: Trent Gu, Fen Huang, James Robert Hartnett
  • Detection of nucleic acid hybrids
    Publication number: 20030077621
    Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of a predetermined endogenous nucleic acid. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, spieciation, determination of viral load, genotyping, medical marker diagnostics, and the like.
    Type: Application
    Filed: May 20, 2002
    Publication date: April 24, 2003
    Applicant: Promega Corporation
    Inventors: John William Shultz, Martin K. Lewis, Donna Leippe, Michelle Mandrekar, Daniel Kephart, Richard Byron Rhodes, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Ryan J. Olson, Keith V. Wood, Roy Welch
  • Method of reverse transcription
    Patent number: 6436677
    Abstract: The present invention relates to reverse transcription of RNA, and in particular to reverse transcription by thermostable DNA polymerases. Thermoactinomyces vulgaris and Bacillus stearothermophilus possess reverse transcriptase activity in the presence of magnesium or manganese ions. Methods, compositions, and kits for reverse transcription and RT-PCR are also provided.
    Type: Grant
    Filed: March 2, 2000
    Date of Patent: August 20, 2002
    Assignee: Promega Corporation
    Inventors: Trent Gu, Fen Huang, James Robert Hartnett
  • Detection of nucleic acid hybrids
    Patent number: 6391551
    Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of a predetermined endogenous nucleic acid. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, speciation, determination of viral load, genotyping, medical marker diagnostics, and the like.
    Type: Grant
    Filed: August 25, 1999
    Date of Patent: May 21, 2002
    Assignee: Promega Corporation
    Inventors: John William Shultz, Martin K. Lewis, Donna Leippe, Michelle Mandrekar, Daniel Kephart, Richard Byron Rhodes, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Ryan J. Olson, Keith V. Wood, Roy Welch
  • Nucleic acid detection
    Patent number: 6312902
    Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of a predetermined nucleic acid. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, speciation, determination of viral load, genotyping, medical marker diagnostics, and the like.
    Type: Grant
    Filed: September 27, 1999
    Date of Patent: November 6, 2001
    Assignee: Promega Corporation
    Inventors: John William Shultz, Martin K. Lewis, Donna Leippe, Michelle Mandrekar, Daniel Kephart, Richard Byron Rhodes, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Ryan J. Olson, Roy Welch
  • Detection of nucleic acid hybrids
    Publication number: 20010031470
    Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of a predetermined nucleic acid. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, speciation, determination of viral load, genotyping, medical marker diagnostics, and the like.
    Type: Application
    Filed: February 22, 2001
    Publication date: October 18, 2001
    Applicant: Promega Corporation
    Inventors: John William Shultz, Martin K. Lewis, Donna Leippe, Michelle Mandrekar, Daniel Kephart, Richard Byron Rhodes, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Ryan J. Olson, Keith V. Wood, Roy Welch
  • Multiplex method for nucleic acid detection
    Patent number: 6270973
    Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of predetermined nucleic acid target sequences using a multiplex assay format. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, speciation, genotyping, medical marker diagnostics, and the like.
    Type: Grant
    Filed: September 27, 1999
    Date of Patent: August 7, 2001
    Assignee: Promega Corporation
    Inventors: Martin K. Lewis, Daniel Kephart, Richard Byron Rhodes, John William Shultz, Donna Leippe, Michelle Mandrekar, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Keith V. Wood, Roy Welch