Abstract: Powder dispensing and sensing apparatus and methods are provided. The powder dispensing and sensing apparatus includes a tray support structure to receive a cartridge tray holding cartridges, a powder dispenser assembly including powder dispenser modules to dispense powder into respective cartridges of a batch of cartridges in the cartridge tray, a powder transport system to deliver powder to the powder dispenser modules, a sensor module including sensor cells to sense respective fill states, such as the weights, of each of the cartridges in the batch of cartridges, and a control system to control the powder dispenser modules in response to the respective sensed fill states of each of the cartridges of the batch of cartridges.

Abstract: Powder dispensing and sensing apparatus and methods are provided. The powder dispensing and sensing apparatus includes a tray support structure to receive a cartridge tray holding cartridges, a powder dispenser assembly including powder dispenser modules to dispense powder into respective cartridges of a batch of cartridges in the cartridge tray, a powder transport system to deliver powder to the powder dispenser modules, a sensor module including sensor cells to sense respective fill states, such as the weights, of each of the cartridges in the batch of cartridges, and a control system to control the powder dispenser modules in response to the respective sensed fill states of each of the cartridges of the batch of cartridges.

Abstract: Powder dispensing and sensing apparatus and methods are provided. The powder dispensing and sensing apparatus includes a tray support structure to receive a cartridge tray holding cartridges, a powder dispenser assembly including powder dispenser modules to dispense powder into respective cartridges of a batch of cartridges in the cartridge tray, a powder transport system to deliver powder to the powder dispenser modules, a sensor module including sensor cells to sense respective fill states, such as the weights, of each of the cartridges in the batch of cartridges, and a control system to control the powder dispenser modules in response to the respective sensed fill states of each of the cartridges of the batch of cartridges.

Abstract: An inhaler is instantly activated upon its removal from a cover or cover unit, and by rotating a cartridge component of the inhaler with respect to a mouthpiece portion, so as to create a flow pathway for ambient air and particles. The cartridge component includes a chamber, whose contents typically include dry powders or the like. Upon creation of the flow pathway, the contents of the chamber are instantly accessible for immediate inhalation by a user through the mouthpiece portion.

Abstract: An inhaler is instantly activated upon its removal from a cover or cover unit, and by rotating a cartridge component of the inhaler with respect to a mouthpiece portion, so as to create a flow pathway for ambient air and particles. The cartridge component includes a chamber, whose contents typically include dry powders or the like. Upon creation of the flow pathway, the contents of the chamber are instantly accessible for immediate inhalation by a user through the mouthpiece portion.

Abstract: An inhaler is instantly activated upon its removal from a cover or cover unit, and by rotating a cartridge component of the inhaler with respect to a mouthpiece portion, so as to create a flow pathway for ambient air and particles. The cartridge component includes a chamber, whose contents typically include dry powders or the like. Upon creation of the flow pathway, the contents of the chamber are instantly accessible for immediate inhalation by a user through the mouthpiece portion.

Abstract: A drug delivery device that aerosolizes a dry powder formulation so that it forms a fine coating in the oral cavity and, more specifically, in the sublingual region of the oral cavity is described herein. In the preferred embodiment, the device contains five main parts: (i) a compressed gas canister, (ii) a dispenser body (also referred to herein as the main housing), (iii) a means for storing one or more doses of a drug formulation, (iv) a means for releasing a dose of the drug formulation such as a gas canister or spring piston and (v) a mouthpiece. Preferred configurations include circular, tubular, and rectangular. The means for storing the drug formulation may be configured to separately store one or more materials. In one embodiment, the means for storing the active agent is in the form of one or more drug discs, where the drug discs contain a plurality of blister packs, each storing one dose of the drug formulation.

Abstract: A dry powder inhaler having improved aerodynamic properties for diluting, dispersing, and metering drug particles for increasing the efficiency of pulmonary drug delivery to a patient is described. The inhaler comprises, in general, a housing having an air intake, an air flow-control/check-valve, a mixing section and a mouthpiece. A cartridge loaded with a single dose of medicament can be installed in the mixing section.

Abstract: An inhaler is instantly activated upon its removal from a cover or cover unit, and by rotating a cartridge component of the inhaler with respect to a mouthpiece portion, so as to create a flow pathway for ambient air and particles. The cartridge component includes a chamber, whose contents typically include dry powders or the like. Upon creation of the flow pathway, the contents of the chamber are instantly accessible for immediate inhalation by a user through the mouthpiece portion.

Abstract: A non-lethal personal defense device that may be carried by a user includes a housing, a nozzle having a discharge orifice, a control valve coupled to the nozzle, a pressurized source containing a bio-active agent and coupled to the nozzle, a rangefinder for determining a range to a target, a trigger mechanism for activating firing of the device and a firing controller. The firing controller operates the control valve to discharge an aerosol plume of the bio-active agent through the nozzle in response to activation of the trigger mechanism and in response to the range determined by the rangefinder. The nozzle may include a spray orifice for discharging a pulsed aerosol spray plume at relatively long range and a mist orifice for discharging a pulsed mist aerosol plume at relatively short range. The pulse parameters are varied in response to the sensed range to the attacker.

Abstract: A non-lethal personal defense device that may be carried by a user includes a housing, a nozzle having a discharge orifice, a control valve coupled to the nozzle, a pressurized source containing a bio-active agent and coupled to the nozzle, a rangefinder for determining a range to a target, a trigger mechanism for activating firing of the device and a firing controller. The firing controller operates the control valve to discharge an aerosol plume of the bio-active agent through the nozzle in response to activation of the trigger mechanism and in response to the range determined by the rangefinder. The nozzle may include a spray orifice for discharging a pulsed aerosol spray plume at relatively long range and a mist orifice for discharging a pulsed mist aerosol plume at relatively short range. The pulse parameters are varied in response to the sensed range to the attacker.

Abstract: A non-lethal personal defense device that may be carried by a user includes a housing, a nozzle having a discharge orifice, a control valve coupled to the nozzle, a pressurized source containing a bio-active agent and coupled to the nozzle, a rangefinder for determining a range to a target, a trigger mechanism for activating firing of the device and a firing controller. The firing controller operates the control valve to discharge an aerosol plume of the bio-active agent through the nozzle in response to activation of the trigger mechanism and in response to the range determined by the rangefinder. The nozzle may include a spray orifice for discharging a pulsed aerosol spray plume at relatively long range and a mist orifice for discharging a pulsed mist aerosol plume at relatively short range. The pulse parameters are varied in response to the sensed range to the attacker.

Abstract: A non-lethal personal defense device that may be carried by a user includes a housing, a nozzle having a discharge orifice, a control valve coupled to the nozzle, a pressurized source containing a bio-active agent and coupled to the nozzle, a rangefinder for determining a range to a target, a trigger mechanism for activating firing of the device and a firing controller. The firing controller operates the control valve to discharge an aerosol plume of the bio-active agent through the nozzle in response to activation of the trigger mechanism and in response to the range determined by the rangefinder. The nozzle may include a spray orifice for discharging a pulsed aerosol spray plume at relatively long range and a mist orifice for discharging a pulsed mist aerosol plume at relatively short range. The pulse parameters are varied in response to the sensed range to the attacker.

Abstract: A non-lethal personal defense device that may be carried by a user includes a housing, a nozzle having a discharge orifice, a control valve coupled to the nozzle, a pressurized source containing a bio-active agent and coupled to the nozzle, a rangefinder for determining a range to a target, a trigger mechanism for activating firing of the device and a firing controller. The firing controller operates the control valve to discharge an aerosol plume of the bio-active agent through the nozzle in response to activation of the trigger mechanism and in response to the range determined by the rangefinder. The nozzle may include a spray orifice for discharging a pulsed aerosol spray plume at relatively long range and a mist orifice for discharging a pulsed mist aerosol plume at relatively short range. The pulse parameters are varied in response to the sensed range to the attacker.

Abstract: Apparatus for determining flowability of a powder by sensing powder avalanching includes a sample drum having a generally cylindrical sample chamber for holding a powder sample, a support frame including a drum shaft for supporting the sample drum for rotation, a drive motor and a drive mechanism coupled between the drive motor and the drum shaft such that the drum rotates when the drive motor is energized. The apparatus further includes an avalanche sensor for sensing avalanching of the powder sample within the sample chamber as the sample drum rotates. The avalanche sensor may be implemented as a backlash sensor for sensing intermittent reverse angular displacement of the sample drum caused by avalanching of the powder sample. A torque loading sensor may also be used to sense avalanching of the powder sample. A controlled gas may be circulated through the sample chamber by a gas conditioning system. The gas in the sample chamber can be measured and/or controlled.

Abstract: A handheld therapeutic material delivery system includes a droplet dispersion chamber, a droplet generating assembly for generating droplets of a fluid containing the therapeutic material and for supplying the droplets to the dispersion chamber, and a gas conditioning assembly for supplying heated gas to the dispersion chamber to form a heated transport gas stream. The droplets are dispersed in the heated transport gas stream in the dispersion chamber to provide an aerosol stream containing the droplets. The aerosol stream is supplied to the patient in response to a negative pressure applied by the patient. The delivery system may include a droplet inspection assembly for determining a characteristic of the aerosol stream and a feedback unit responsive to the determined characteristic of the aerosol stream for controlling one or both of the droplet generating assembly and the gas conditioning assembly.

Abstract: Apparatus for determining flowability of a powder by sensing powder avalanching includes a sample drum having a generally cylindrical sample chamber for holding a powder sample, a support frame including a drum shaft for supporting the sample drum for rotation, a drive motor and a drive mechanism coupled between the drive motor and the drum shaft such that the drum rotates when the drive motor is energized. The apparatus further includes an avalanche sensor for sensing avalanching of the powder sample within the sample chamber as the sample drum rotates. The avalanche sensor may be implemented as a backlash sensor for sensing intermittent reverse angular displacement of the sample drum caused by avalanching of the powder sample. A torque loading sensor may also be used to sense avalanching of the powder sample. A controlled gas may be circulated through the sample chamber by a gas conditioning system. The gas in the sample chamber can be measured and/or controlled.

Abstract: Apparatus for determining flowability of a powder by sensing powder avalanching includes a sample drum having a generally cylindrical sample chamber for holding a powder sample, a support frame including a drum shaft for supporting the sample drum for rotation, a drive motor and a drive mechanism coupled between the drive motor and the drum shaft such that the drum rotates when the drive motor is energized. The apparatus further includes an avalanche sensor for sensing avalanching of the powder sample within the sample chamber as the sample drum rotates. The avalanche sensor may be implemented as a backlash sensor for sensing intermittent reverse angular displacement of the sample drum caused by avalanching of the powder sample. A torque loading sensor may also be used to sense avalanching of the powder sample. A controlled gas may be circulated through the sample chamber by a gas conditioning system. The gas in the sample chamber can be measured and/or controlled.

Abstract: A paint can guard is mounted on a sealing rim of a paint can. The paint can guard includes an annular rim guard for covering the sealing rim of the paint can, an annular brush wiper having an inner surface and an outer surface, and a plurality of struts coupled between the rim guard and the wiper for supporting the wiper in spaced relation to the rim guard. A substantially annular passage is defined between the outer surface of the wiper and the rim guard. Paint from a brush wiped on the wiper may flow on the inner surface of the wiper into the paint can. The brush can also be wiped on the upper or lower edge of the wiper. Paint that drips or spills outwardly of the wiper may flow through the passage between the outer surface of the wiper and the rim guard into the paint can, thus avoiding spillage.

Abstract: A powder dispersion system, including a powder disperser and a control unit, supplies a controlled particle stream to a particle sizing system, instrument, or other processing device. The powder disperser includes a dynamic shear dispersion assembly and may include a fluidization assembly. An impact surface for deagglomeration of particles is located within a rapid acceleration chamber of the dynamic shear dispersion assembly. The particles are accelerated from the impact surface through an annular nozzle. A feedback loop dynamically controls the dynamic shear force applied to the aerosol transport gas, which in turn places reaction forces upon the particles, within the annular nozzle. The fluidization assembly includes a primary chamber for holding a powder sample and a secondary chamber for entraining particles of the powder sample in a transport gas stream. A pulsed gas jet directed into the primary chamber disperses particles of the powder sample into the secondary chamber.