Patents by Inventor Tsong-Toh Yang
Tsong-Toh Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8173172Abstract: The invention relates to a method of producing an agglomerate of drug and solid binder. The process involves producing individual agglomerate particles and then converting the convertible amorphous content of same, following agglomeration, by the application of, for example, moisture. Agglomerates capable of conversion as well as the finished agglomerates and oral and nasal dosing systems including same are also contemplated. The process produces agglomerates which are rugged but which will produce an acceptable fine particle fraction during dosing.Type: GrantFiled: November 29, 2007Date of Patent: May 8, 2012Assignee: Schering CorporationInventor: Tsong-Toh Yang
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Patent number: 7687073Abstract: The invention relates to a method of producing an agglomerate of drug and solid binder. The process involves producing individual agglomerate particles and then converting the convertible amorphous content of same, following agglomeration, by the application of, for example, moisture. Agglomerates capable of conversion as well as the finished agglomerates and oral and nasal dosing systems including same are also contemplated. The process produces agglomerates which are rugged but which will produce an acceptable fine particle fraction during dosing.Type: GrantFiled: May 8, 2008Date of Patent: March 30, 2010Assignee: Schering CorporationInventor: Tsong-Toh Yang
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Publication number: 20090298802Abstract: Disclosed are inhalable medicaments and methods based on an anticholinergic in combination with a corticosteroid, and a long acting beta agonist, for simultaneous or sequential administration in the prevention or treatment of a respiratory, inflammatory or obstructive airway disease. In addition, disclosed are inhalable medicaments and methods based on combinations of an anticholinergic and a corticosteroid; an anticholinergic and a long acting beta agonist; or a corticosteroid and a long acting beta agonist, for simultaneous or sequential administration in the prevention or treatment of a respiratory, inflammatory or obstructive airway disease. Also disclosed are inhalable medicaments and methods comprising a phosphodiesterase IV inhibitor for administration in the prevention or treatment of a respiratory, inflammatory or obstructive airway disease.Type: ApplicationFiled: March 30, 2006Publication date: December 3, 2009Inventors: Joel A. Sequeira, Tsong-Toh Yang
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Publication number: 20080206346Abstract: The invention relates to a method of producing an agglomerate of drug and solid binder. The process involves producing individual agglomerate particles and then converting the convertible amorphous content of same, following agglomeration, by the application of, for example, moisture. Agglomerates capable of conversion as well as the finished agglomerates and oral and nasal dosing systems including same are also contemplated. The process produces agglomerates which are rugged but which will produce an acceptable fine particle fraction during dosing.Type: ApplicationFiled: May 8, 2008Publication date: August 28, 2008Inventor: Tsong-Toh Yang
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Patent number: 7387794Abstract: The invention relates to a method of producing an agglomerate of drug and solid binder. The process involves producing individual agglomerate particles and then converting the convertible amorphous content of same, following agglomeration, by the application of, for example, moisture. Agglomerates capable of conversion as well as the finished agglomerates and oral and nasal dosing systems including same are also contemplated. The process produces agglomerates which are rugged but which will produce an acceptable fine particle fraction during dosing.Type: GrantFiled: January 4, 2005Date of Patent: June 17, 2008Assignee: Schering CorporationInventor: Tsong-Toh Yang
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Publication number: 20080118566Abstract: The invention relates to a method of producing an agglomerate of drug and solid binder. The process involves producing individual agglomerate particles and then converting the convertible amorphous content of same, following agglomeration, by the application of, for example, moisture. Agglomerates capable of conversion as well as the finished agglomerates and oral and nasal dosing systems including same are also contemplated. The process produces agglomerates which are rugged but which will produce an acceptable fine particle fraction during dosing.Type: ApplicationFiled: November 29, 2007Publication date: May 22, 2008Inventor: Tsong-Toh Yang
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Publication number: 20050123608Abstract: The invention relates to a method of producing an agglomerate of drug and solid binder. The process involves producing individual agglomerate particles and then converting the convertible amorphous content of same, following agglomeration, by the application of, for example, moisture. Agglomerates capable of conversion as well as the finished agglomerates and oral and nasal dosing systems including same are also contemplated. The process produces agglomerates which are rugged but which will produce an acceptable fine particle fraction during dosing.Type: ApplicationFiled: January 4, 2005Publication date: June 9, 2005Inventor: Tsong-Toh Yang
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Publication number: 20040109828Abstract: The invention relates to a method of producing an agglomerate of drug and solid binder. The process involves producing individual agglomerate particles and then converting the convertible amorphous content of same, following agglomeration, by the application of, for example, moisture. Agglomerates capable of conversion as well as the finished agglomerates and oral and nasal dosing systems including same are also contemplated. The process produces agglomerates which are rugged but which will produce an acceptable fine particle fraction during dosing.Type: ApplicationFiled: December 2, 2003Publication date: June 10, 2004Inventor: Tsong-Toh Yang
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Patent number: 6623760Abstract: Methods of preparing particulates for agglomeration, having a specified particle size distribution and desired convertible amorphous content, are described. The method involves a plurality of micronizing steps at least two of which are separated by a curing step. In the curing step, a stimulus such as humidity may be used to crystallize at least some, and in many instances preferably all, of the convertible amorphous content.Type: GrantFiled: January 26, 2000Date of Patent: September 23, 2003Assignee: Schering CorporationInventors: Tsong-Toh Yang, Stephen K. C. Yu, Charles G. Eckhart, Michael B. Mitchell
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Publication number: 20030157184Abstract: The invention relates to a method of producing an agglomerate of drug and solid binder. The process involves producing individual agglomerate particles and then converting the convertible amorphous content of same, following agglomeration, by the application of, for example, moisture. Agglomerates capable of conversion as well as the finished agglomerates and oral and nasal dosing systems including same are also contemplated. The process produces agglomerates which are rugged but which will produce an acceptable fine particle fraction during dosing.Type: ApplicationFiled: December 19, 2002Publication date: August 21, 2003Inventor: Tsong-Toh Yang
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Publication number: 20030085480Abstract: The invention relates to a method of producing an agglomerate of drug and solid binder. The process involves producing individual agglomerate particles and then converting the convertible amorphous content of same, following agglomeration, by the application of, for example, moisture. Agglomerates capable of conversion as well as the finished agglomerates and oral and nasal dosing systems including same are also contemplated. The process produces agglomerates which are rugged but which will produce an acceptable fine particle fraction during dosing.Type: ApplicationFiled: September 10, 2002Publication date: May 8, 2003Inventor: Tsong-Toh Yang
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Patent number: 6503537Abstract: The invention relates to a method of producing an agglomerate of drug and solid binder. The process involves producing individual agglomerate particles and then converting the convertible amorphous content of same, following agglomeration, by the application of, for example, moisture. Agglomerates capable of conversion as well as the finished agglomerates and oral and nasal dosing systems including same are also contemplated. The process produces agglomerates which are rugged but which will produce an acceptable fine particle fraction during dosing.Type: GrantFiled: April 2, 2001Date of Patent: January 7, 2003Assignee: Schering CorporationInventor: Tsong-Toh Yang
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Patent number: 6495167Abstract: The invention relates to a method of producing an agglomerate of drug and solid binder. The process involves producing individual agglomerate particles and then converting the convertible amorphous content of same, following agglomeration, by the application of, for example, moisture. Agglomerates capable of conversion as well as the finished agglomerates and oral and nasal dosing systems including same are also contemplated. The process produces agglomerates which are rugged but which will produce an acceptable fine particle fraction during dosing.Type: GrantFiled: July 9, 2001Date of Patent: December 17, 2002Assignee: Schering CorporationInventor: Tsong-Toh Yang
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Publication number: 20010051187Abstract: The invention relates to a method of producing an agglomerate of drug and solid binder. The process involves producing individual agglomerate particles and then converting the convertible amorphous content of same, following agglomeration, by the application of, for example, moisture. Agglomerates capable of conversion as well as the finished agglomerates and oral and nasal dosing systems including same are also contemplated. The process produces agglomerates which are rugged but which will produce an acceptable fine particle fraction during dosing.Type: ApplicationFiled: July 9, 2001Publication date: December 13, 2001Inventor: Tsong-Toh Yang
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Publication number: 20010024641Abstract: The invention relates to a method of producing an agglomerate of drug and solid binder. The process involves producing individual agglomerate particles and then converting the convertible amorphous content of same, following agglomeration, by the application of, for example, moisture. Agglomerates capable of conversion as well as the finished agglomerates and oral and nasal dosing systems including same are also contemplated. The process produces agglomerates which are rugged but which will produce an acceptable fine particle fraction during dosing.Type: ApplicationFiled: April 2, 2001Publication date: September 27, 2001Inventor: Tsong-Toh Yang
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Patent number: 6240918Abstract: A powder dispenser includes a reservoir body including a supply of powder and an inhalation conduit; a driving body for rotating the reservoir body and including upper recesses and two spring fingers in lower driving recesses thereof; a rotatable metering plate for carrying a metered amount of powder from the supply to the inhalation conduit, and having an underside with ribs; a gas permeable retainer welded to the ribs; a spring biasing the metering plate toward the reservoir body; a nozzle having spiked ribs welded in the upper recesses of the driving body and including a chimney with vertical flutes; an adapter non-rotatably mounted with respect to the metering plate and including two locking recesses for receiving the spring fingers for locking engagement and two helical cam tracks with a square cross-section; a closure cap covering the driving body and including priming ribs biasing the spring fingers out of the locking recesses and engaging with the locking recesses to rotate the driving body, and two cType: GrantFiled: February 20, 1997Date of Patent: June 5, 2001Assignee: Schering CorporationInventors: Thomas J. Ambrosio, Warren A. Benson, Jr., Kim C. Dao, David J. Kenyon, Walter J. Kreiseder, Theodore J. Schonebaum, Allen J. Vogel, Louis B. Walker, Tsong-Toh Yang
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Patent number: 5829434Abstract: A powder inhaler comprising:a powder housing for holding a supply of powdered material to be dispensed and a metering plate for holding a metered amount of said powdered material, the metering plate being alternately positionable below said supply of powdered material or within an inhalation conduit, by means of a bi-directional, angle-limited relative rotation about a common central axis;a counter for providing a visual count of the number of doses of said powdered material that have been dispensed or remain to be dispensed in response to the relative rotation, the counter including: a continuous counter ring and a coaxially mounted intermittent counter ring, both rings being mounted on a base in surrounding relation to a retaining post, being rotatable about the common central axis and having counting indicia thereon for displaying said visual count; anda display means through which at least one of the counting indicia is displayed to indicate a count corresponding to a number of doses of powdered materialType: GrantFiled: June 1, 1995Date of Patent: November 3, 1998Assignee: Schering CorporationInventors: Thomas J. Ambrosio, Charles R. Ashley, Alan J. Bilanin, Charles M. Huck, Andrew E. Kaufman, David J. Kenyon, Srinivas Manthena, Henry R. Sochon, Ken Wilkinson, Tsong-Toh Yang
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Patent number: 5687710Abstract: A powder dispenser includes a powder housing for holding a supply of powdered material to be dispensed, the powder housing including an inhalation conduit provided displaced relation to the powdered material supply; a metering plate including a metered dose hole for holding a metered amount of the powdered material, and positioned below the powdered material supply, the metering plate and the powder housing being relatively rotatable with respect to each other about a common central axis; a counter providing a visual count of the number of doses of the powdered material that have been dispensed or remain to be dispensed in response to the relative rotation, the counter including counter rings providing the visual count, the counter rings being rotatable about the common central axis and having indicia thereon which display the visual count, and an actuating mechanism rotatable about the central axis for incrementally rotating the counter rings in response to the relative rotation; a nozzle for breaking up aggType: GrantFiled: June 1, 1995Date of Patent: November 18, 1997Assignee: Schering CorporationInventors: Thomas J. Ambrosio, Alan J. Bilanin, Andrew E. Kaufman, David J. Kenyon, Srinivas Manthena, Tsong-Toh Yang