Abstract: The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases. The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.

Abstract: An edging roll for rolling a shape having a web and flanges, including a main shaft having an eccentric shaft portion; an eccentric sleeve having an eccentric portion facing the eccentric shaft portion of the main shaft; web-restricting rollers attached to the eccentric shaft portion of the main shaft and the eccentric portion of the eccentric sleeve through bearings; flange rolling rolls attached to the main shaft and the eccentric sleeve through bearings; a flange rolling roll drive means having a pair of gear transmission means, a connection shaft, and a rotation drive means; a roll height adjustment means for integrally rotating the main shaft and the eccentric sleeve; a roll-width adjustment means for synchronously and mutually moving the main shaft and the eccentric sleeve; and further a roll width/height adjustment synchronizing means and a pair of guide rings may also be disposed.

Abstract: A guide device for shape rolling has upper and lower pairs of width-variable web guides arranged at the delivery of a shape mill. Support bases supporting the upper and lower pairs of web guides. Movable bases move the support bases horizontally on side frames whose ends are fixed to guide frames. Guide width adjusting devices individually adjust the distance between the movable bases; and guide height adjusting devices enable the side frames to ascend and descend. Preferably, upper and lower pairs of flange end guide rollers and flange-outer-surface guide rollers, which are adapted to roll while in contact with the end surfaces and the outer surfaces of the flanges, can move in the vertical and horizontal directions.

Abstract: A roller-type straightening apparatus for an H-beam having horizontal rolls for pressing the web of the H-beam are alternately vertically disposed. Pairs of vertical rolls press the outer surfaces of the opposed flanges of the H-beam. The horizontal roll presses the surface of the web of the H-beam. The pairs of vertical rolls are located to correspond in position to each of the horizontal rolls.

Abstract: A section steel straightener for correcting deformations in section steel, such as H-beams. The straightener allows for adjusting the width of the rollers without disassembling the apparatus, but rather by rotating sleeves to change the distance between rollers. Also disclosed is a plurality of rollers forming at least one of the fixed roller and movable roller such that the required amount of movement of the movable roller is reduced, thereby reducing idle time of the straightener.

Abstract: Adjustable width rolls are preferably used for rolling, for example, insides of H-beams of various sizes without exchanging horizontal rolls of a rolling mill. Each of the adjustable width rolls includes a roll shaft rotatably and axially movably supported relative to the rolling mill, and axially adjustable sleeve roll fixed to the roll shaft, and an axially stationary sleeve roll mounted on the roll shaft to be axially slidable but against rotatable relatively to the roll shaft. The adjustable width roll further includes an axially adjustable roll fixedly supported by the axially adjustable sleeve roll to form substantially one half of a rolling barrel of the adjustable width roll, an axially stationary roll fixedly supported by the axially stationary sleeve roll to form substantially the remaining half of the rolling barrel of the adjustable width roll, and a driving mechanism for driving the roll shaft in axial directions of the roll shaft.

Abstract: H-shaped steel products having substantially a constant web height are efficiently manufactured from workpieces after breakdown rolling by using a particular universal rolling mill comprising a pair of width variable horizontal rolls and a pair of vertical rolls in rough universal rolling and/or finish universal rolling stages without arrangement of rolls in the same size series having different flange thicknesses.