Patents by Inventor Tsung-Ying Shen
Tsung-Ying Shen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4265905Abstract: Certain novel acyl cyanoguanidines, their preparation, pharmaceutical compositions and novel methods of treating inflammation and autoimmune diseases such as rheumatoid arthritis are disclosed.Type: GrantFiled: November 13, 1979Date of Patent: May 5, 1981Assignee: Merck & Co., Inc.Inventors: Tsung-Ying Shen, Howard Jones
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Patent number: 4259324Abstract: Compounds of the formulae Y--R wherein Y is 1-thio-.beta.-L-fucose, 1-thio-.beta.-D-galactose or 1-thio-.beta.-lactose and R is 2-(1-adamantyl)ethyl, 3-[(p-tetrafluorophenethyl)phenyl]propyl, 6-(5-cholesten-3.beta.-yloxy)hex-3-ynl, oleyl, or hexadecyl are useful immunologic adjuvants in vaccines.Type: GrantFiled: July 31, 1979Date of Patent: March 31, 1981Assignee: Merck & Co., Inc.Inventors: Mitree M. Ponpipom, Tsung-Ying Shen, Robert L. Bugianesi
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Patent number: 4256735Abstract: 2-Amino-2-deoxy-glycoses of the general structural formula: ##STR1## wherein R.sub.1 is hydrogen, alkyl (1-7C), substituted alkyl (1-7C), phenyl, substituted phenyl, benzyl, or substituted benzyl;R.sub.2 is alkyl, substituted alkyl, phenyl, or substituted phenyl;R.sub.3 is H or lower alkyl (1-10C) with the proviso that when the aminoglycose has the 2-amino-2-deoxy-D-glucose configuration, R.sub.3 cannot be H;R.sub.4 and R.sub.5 are same or different and are H, aliphatic or aromatic acyl (2-21C) or substituted acyl (2-21C);R.sub.6 is H, or R.sub.6 -R.sub.7 together is --CH.sub.2 --CH.sub.2 --CH.sub.2 --,R.sub.7 is H, alkyl (1-7C), hydroxymethyl, mercaptomethyl, benzyl, or substituted benzyl;R.sub.8 and R.sub.9 each is carboxyl, esterified carboxyl (1-7C), amidated carboxyl, or mono- or di-alkyl-(1-3C)-amidated carboxyl;Provided that when R.sub.Type: GrantFiled: January 29, 1979Date of Patent: March 17, 1981Assignee: Merck & Co., Inc.Inventors: Philippe L. Durette, Tsung-Ying Shen
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Patent number: 4229441Abstract: Glycolipid compounds of the formulae ##STR1## wherein R is ##STR2## are useful immunologic adjuvants in vaccines.Type: GrantFiled: December 1, 1978Date of Patent: October 21, 1980Assignee: Merck & Co., Inc.Inventors: Robert L. Bugianesi, Mitree M. Ponpipom, Tsung-Ying Shen
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Patent number: 4228161Abstract: A novel drug combination for more effective treatment of pain, fever, and inflammation with reduced ulcerogenicity comprising (a) 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid (indomethacin), and (b) a member selected from phenyl benzoic acid compounds, especially 2-hydroxy-5-(2',4'-difluorophenyl)benzoic acid (diflunisal), wherein the molar ratio of (b) to (a) is from 0.5 to 1.0 to 15.0 to 1.0.Type: GrantFiled: March 28, 1979Date of Patent: October 14, 1980Assignee: Merck & Co., Inc.Inventor: Tsung-Ying Shen
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Patent number: 4228274Abstract: The invention disclosed herein relates to novel 1-deoxy-glycopyranosides, preferably 1-deoxy-D-mannopyranosides, having in the 1-position of the pyranoside ring an .omega.-aminoalkylthio, .omega.-aminoalkyloxy or .omega.-aminoalkanoylamino substituent; and to novel processes for preparing these 1-substituted-1-deoxy-glycopyranosides starting with the corresponding tetra-O-acetyl-glycopyranosyl bromide or amine. These .omega.-amino(alkylthio, alkyloxy or alkanoylamino)-1-deoxy-glycopyranosides, and in particular 1-[(6'-aminohexyl)thio or oxy]-1-deoxy-D-mannopyranosides, possess insulin-like activity.Type: GrantFiled: July 10, 1978Date of Patent: October 14, 1980Assignee: Merck & Co., Inc.Inventors: Mitree M. Ponpipom, Robert L. Bugianesi, Philippe L. Durette, Howard M. Katzen, Tsung-Ying Shen
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Patent number: 4217429Abstract: Novel polymers having a linear backbone which is free from both branching and cross-linking, comprising quaternized nitrogen atoms linked to each other through trimethylene groups. By the term "linear backbone" is meant that the polymer has only acyclic groups, i.e. trimethylene, linking the nitrogen atoms in a single continuous chain; the polymer is free from "branching" when it has no repeating monomer units extending from the polymer backbone; and it is free from "cross-linking" when there is no joining of two linear backbones. These polymers are useful as antimicrobials, flocculating agents, antistatic agents, electroconductive agents for coating paper, chelating agents and bile acid binding agents, as well as in similar applications where their high charge to weight ratio and fully accessible nitrogen atoms can be employed. The polymers are obtained by the polymerization of dihydro-oxazine, reductive alkylation of the resulting polymer, followed by quaternization.Type: GrantFiled: April 11, 1979Date of Patent: August 12, 1980Assignee: Merck & Co., Inc.Inventors: Arthur F. Wagner, Nathaniel Grier, Tsung-Ying Shen
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Patent number: 4217352Abstract: Mercaptoalkylpyridines carrying an ethenyl or ethynyl substituent are prepared from known pyridine compounds, principally pyridoxine, by known chemical procedures, and are useful in the treatment of rheumatoid arthritis and related inflammatory diseases.Type: GrantFiled: February 7, 1979Date of Patent: August 12, 1980Assignee: Merck & Co., Inc.Inventors: Tsung-Ying Shen, Howard Jones, Conrad P. Dorn
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Patent number: 4212976Abstract: Mercaptoalkylpyridines and various derivatives thereof have utility in the treatment of rheumatoid arthritis. The compounds useful in the method of treatment are generally prepared from known pyridine derivatives and, principally, from pyridoxine and related compounds.Type: GrantFiled: September 20, 1977Date of Patent: July 15, 1980Assignee: Merck & Co., Inc.Inventors: Tsung-Ying Shen, Howard Jones, Dennis M. Mulvey, Conrad P. Dorn
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Patent number: 4206295Abstract: Novel polymers having a linear backbone which is free from both branching and cross-linking, comprising quaternized nitrogen atoms linked to each other through trimethylene groups. By the term "linear backbone" is meant that the polymer has only acyclic groups, i.e. trimethylene, linking the nitrogen atoms in a single continuous chain; the polymer is free from "branching" when it has no repeating monomer units extending from the polymer backbone; and it is free from "cross-linking" when there is no joining of two linear backbones. These polymers are useful as antimicrobials, flocculating agents, antistatic agents, electroconductive agents for coating paper, chelating agents and bile acid binding agents, as well as in similar applications where their high charge to weight ratio and fully accessible nitrogen atoms can be employed. The polymers are obtained by the polymerization of dihydro-oxazine, reductive alkylation of the resulting polymer, followed by quaternization.Type: GrantFiled: April 11, 1979Date of Patent: June 3, 1980Assignee: Merck & Co., Inc.Inventors: Arthur F. Wagner, Nathaniel Grier, Tsung-Ying Shen
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Patent number: 4202903Abstract: Certain novel acyl cyanoguanidines, their preparation, pharmaceutical compositions and novel methods of treating inflammation and autoimmune diseases such as rheumatoid arthritis are disclosed.Type: GrantFiled: September 30, 1975Date of Patent: May 13, 1980Assignee: Merck & Co., Inc.Inventors: Tsung-Ying Shen, Howard Jones
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Patent number: 4189471Abstract: Glycolipid compounds of the formulae ##STR1## are useful immunologic adjuvants in vaccines.Type: GrantFiled: July 11, 1978Date of Patent: February 19, 1980Assignee: Merck & Co., Inc.Inventors: Mitree M. Ponpipom, John Chabala, Tsung-Ying Shen
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Patent number: 4161581Abstract: Novel polymers having a linear backbone which is free from both branching and cross-linking, comprising either tertiary or quaternized nitrogen atoms linked to each other through ethylene groups. These polymers are useful as antimicrobials, flocculating agents, antistatic agents, electroconductive agents for coating paper, chelating agents and bile acid binding agents, as well as in similar applications where their high charge to weight ratio and fully accessible nitrogen atoms can be employed. The polymers are obtained by the polymerization of an oxazoline, hydrolysis or direct reduction, nitrogen substitution, and optional quaternization of the resulting polymer.Type: GrantFiled: September 29, 1977Date of Patent: July 17, 1979Assignee: Merck & Co., Inc.Inventors: Arthur F. Wagner, Nathaniel Grier, Tsung-Ying Shen
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Patent number: 4144342Abstract: Mercaptoalkylpyridines carrying an ethenyl or ethynyl substituent are prepared from known pyridine compounds, principally pyridoxine, by known chemical procedures, and are useful in the treatment of rheumatoid arthritis and related inflammatory diseases.Type: GrantFiled: October 17, 1977Date of Patent: March 13, 1979Assignee: Merck & Co., Inc.Inventors: Tsung-Ying Shen, Howard Jones, Conrad P. Dorn
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Patent number: 4144341Abstract: 1,3-Dihydroimidazo[4,5-b]pyridin-2-ones and corresponding thiones have utility as analgesic, antipyretic and antiinflammatory agents. They are generally prepared by treatment of a 2,3-diaminopyridine with phosgene or thiosphosgene followed by further substitution if desired.Type: GrantFiled: November 22, 1977Date of Patent: March 13, 1979Assignee: Merck & Co., Inc.Inventors: Robert L. Clark, Arsenio A. Pessolano, Tsung-Ying Shen
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Patent number: 4131677Abstract: The various isomers of oxazolo- and thiazolopyridines having utility as antiinflammatory, antipyretic and analgesic agents are prepared by condensation of an appropriate amino-hydroxypyridine or amino-mercaptopyridine with a carboxylic acid, halide or anhydride.Type: GrantFiled: April 27, 1977Date of Patent: December 26, 1978Assignee: Merck & Co., Inc.Inventors: Tsung-Ying Shen, Robert L. Clark, Arsenio A. Pessolano, Bruce E. Witzel, Thomas J. Lanza
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Patent number: 4098726Abstract: Novel polymers having a linear backbone which is free from both branching and cross-linking, comprising quaternized nitrogen atoms linked to each other through trimethylene groups. By the term "linear backbone" is meant that the polymer has only acyclic groups, i. e. trimethylene, linking the nitrogen atoms in a single continuous chain; the polymer is free from "branching" when it has no repeating monomer units extending from the polymer backbone; and it is free from "cross-linking" when there is no joining of two linear backbones. These polymers are useful as antimicrobials, flocculating agents, antistatic agents, electroconductive agents for coating paper, chelating agents and bile acid binding agents, as well as in similar applications where their high charge to weight ratio and fully accessible nitrogen atoms can be employed. The polymers are obtained by the polymerization of dihydro-oxazine, reductive alkylation of the resulting polymer, followed by quaternization.Type: GrantFiled: April 1, 1977Date of Patent: July 4, 1978Assignee: Merck & Co., Inc.Inventors: Arthur F. Wagner, Nathaniel Grier, Tsung-Ying Shen
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Patent number: 4087549Abstract: New substituted indenyl methyl sulfonic acids and derivatives thereof which have anti-inflammatory, antipyretic and analgesic activity. Also included are methods of preparing said indenyl compounds, pharmaceutical compositions having said indenyl compounds as an active ingredient and methods of treating inflammation by administration of said indenyl compounds.Type: GrantFiled: December 20, 1976Date of Patent: May 2, 1978Assignee: Merck & Co., Inc.Inventors: Tsung-Ying Shen, Howard Jones
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Patent number: 4071478Abstract: The invention disclosed herein relates to novel partially cross-linked, fully quaternized poly-[(methylimino)trimethylene] polymers wherein a minor proportion (1% to 20%) of the nitrogen atoms in adjacent poly-[(methylimino)trimethylene] linear chains are, by quaternization, joined through trimethylene or 2-hydroxy-trimethylene bridges, the non-cross-linked nitrogens in the said linear chains being fully quaternized with lower alkyl or trialkylammoniopropyl groupings; and to the novel process for preparing these partially cross-linked, fully quaternized polymers which comprises reacting poly-[(methylimino)trimethylene] with 0.01 to 0.2 equivalents of 1,3-dihalo-propane or 1,3-dihalo-2-hydroxypropane per equivalent of tertiary amine in said poly-[(methylimino)trimethylene], and subsequently reacting the resulting product with excess alkyl halide or 3-halopropyltrialkylammonium halide.Type: GrantFiled: June 7, 1976Date of Patent: January 31, 1978Assignee: Merck & Co., Inc.Inventors: Tsung-Ying Shen, Arthur F. Wagner
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Patent number: 4061759Abstract: Mercaptoalkylpyridines carrying an ethenyl or ethynyl substituent are prepared from known pyridine compounds, principally pyridoxine, by known chemical procedures, and are useful in the treatment of rheumatoid arthritis and related inflammatory diseases.Type: GrantFiled: July 16, 1976Date of Patent: December 6, 1977Assignee: Merck & Co., Inc.Inventors: Tsung-Ying Shen, Howard Jones, Conrad P. Dorn