Abstract: A method for manufacturing a surface-treated gas-phase-process silica particle, the method including steps of: adding 1,3-divinyl-1,1,3,3-tetramethyldisilazane to a raw material gas-phase-process silica particle and introducing a vinyldimethylsilyl group on a surface of the raw material gas-phase-process silica particle to obtain a preliminarily treated silica particle; and adding hexamethyldisilazane to the preliminarily treated silica particle and introducing a trimethylsilyl group on a surface of the preliminarily treated silica particle to obtain a surface-treated gas-phase-process silica particle.

Abstract: The present invention provides an antitumor agent and the like, which comprises as an active ingredient, a pyrimidine derivative represented by Formula (I): [wherein —X—Y—Z— represents —O—CR3?N— (wherein R3 represents a hydrogen atom, a substituted or unsubstituted aromatic heterocyclic group and the like) and the like, R1 represents —NR10R11 (wherein R10 and R11 may be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl and the like) and the like, R2 represents —NR13R14 (wherein R13 and R14 may be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl and the like)] or a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides a method for producing an indazol-3-ylmethyl phosphonium salt represented by Formula (IV): [wherein X represents halogen, OSO2Ra (wherein Ra represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like), or OC(?O)Rb (wherein Rb has the same meaning as the above Ra), or the like, and R1, R2 and R3 may be the same or different and each represents substituted or unsubstituted aryl or the like] or a salt thereof, which comprises reacting a compound represented by Formula (I): a compound represented by Formula (II): H—X??(II) (wherein X has the same meaning as defined above), and a compound represented by Formula (III): (wherein R1, R2 and R3 have the same meanings as defined above, respectively), and the like.

Abstract: [wherein m and n may be the same or different and each represents an integer of 1 to 3 wherein m+n is 4 or less; R1 represents —NR4R5 (wherein R4 and R5 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl or the like); R2 represents the above Formula (II), Formula (IV) or the like; A represents a single bond, —C(?O)—, —SO2—, —OC(?O)— or the like; and R3 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl or the like] Bicyclic pyrimidine derivatives represented by the above Formula (I), or quaternary ammonium salts thereof, or pharmaceutically acceptable salts thereof, or the like, are provided.

Abstract: The present invention provides a method for producing an indazol-3-ylmethyl phosphonium salt represented by Formula (IV): [wherein X represents halogen, OSO2Ra (wherein Ra represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like), or OC(?O)Rb (wherein Rb has the same meaning as the above Ra), or the like, and R1, R2 and R3 may be the same or different and each represents substituted or unsubstituted aryl or the like] or a salt thereof, which comprises reacting a compound represented by Formula (I): a compound represented by Formula (II): H—X??(II) (wherein X has the same meaning as defined above), and a compound represented by Formula (III): (wherein R1, R2 and R3 have the same meanings as defined above, respectively), and the like.

Abstract: The present invention provides an antitumor agent and the like, which comprises as an active ingredient, a pyrimidine derivative represented by Formula (I): [wherein —X—Y-Z- represents —O—CR3?N— (wherein R3 represents a hydrogen atom, a substituted or unsubstituted aromatic heterocyclic group and the like) and the like, R1 represents —NR10R11 (wherein R10 and R11 may be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl and the like) and the like, R2 represents —NR13R14 (wherein R13 and R14 may be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl and the like)] or a pharmaceutically acceptable salt thereof.

Abstract: A 3-frequency branching circuit in the past could not be used for a system wherein a TDMA method such as GSM and DCS and a W-CDMA method such as UMTS are mixed. The 3-frequency branching circuit equipped with branching means having first and second internal terminals, an antenna terminal of connecting to an antenna, a low-pass filter connected between the first internal terminal and the antenna terminal, and a high-pass filter connected between the second internal terminal and the antenna terminal, a switching circuit of switching between GSM TX and GSM RX, a switching circuit of switching between DCS TX, DCS RX and a third internal terminal, and a duplexer connected to the third internal terminal.

Abstract: [wherein m and n may be the same or different and each represents an integer of 1 to 3 wherein m+n is 4 or less; R1 represents —NR4R5 (wherein R4 and R5 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl or the like); R2 represents the above Formula (II), Formula (IV) or the like; A represents a single bond, —C(?O)—, —SO2—, —OC(?O)— or the like; and R3 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl or the like] Bicyclic pyrimidine derivatives represented by the above Formula (I), or quaternary ammonium salts thereof, or pharmaceutically acceptable salts thereof, or the like, are provided.

Abstract: The present invention provides an agent for prevention and/or treatment of itching comprising a substance capable of suppressing the function involved in signal transduction of GPR4 as an active ingredient. It also provides a nitrogen-containing tricyclic compound represented by the formula (I) or a quaternary ammonium salt thereof, or a pharmaceutically acceptable salt thereof; [wherein R1 represents substituted or unsubstituted lower alkyl, etc.; R2 represents hydrogen, substituted or unsubstituted lower alkyl, etc.; R3 and R4 are the same or different and each represents hydrogen, lower alkyl, etc.; n represents 0 or 1; X represents —(CH2)2—, etc.; and Y represents the formula (II); (wherein W represents CH or a nitrogen atom; Z1 and Z2 are the same or different and each represents hydrogen, substituted or unsubstituted lower alkyl, etc.; and Z3 represents hydrogen, substituted or unsubstituted lower alkyl, etc.

Abstract: To provide a laminated band-pass filter comprising at least two band-pass filters without reducing the Q factor of strip line conductors constituting the band-pass filters. A laminated band-pass filter comprises an integrated device formed by laminating and integrating a plurality of dielectric layers together, a plurality of internal grounding conductors formed inside the integrated device, and two band-pass filters sandwiched between two of the plurality of grounding conductors and formed inside the integrated device. One of the band-pass filters has strip line conductors, and the other has strip line conductors. The two band-pass filters are formed in different areas with a boundary between these areas corresponding to a predetermined cross section substantially perpendicular to the grounding conductors.

Abstract: The present invention provides a compound represented by formula (I): [wherein X—Y-Z represents R5N—C?O (wherein R5 represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted lower alkenyl, or substituted or unsubstituted lower alkynyl), etc; R1 and R2 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, etc; and R3 and R4 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, etc], or a pharmaceutically acceptable salt thereof.

Abstract: A laminated filter includes: a first dielectric layer having a first shield electrode on one principal plane; a second dielectric layer having resonator electrodes on one principal plane; a third dielectric layer having a coupling electrode provided facing part of the above-described resonator electrodes; a fourth dielectric layer having a second shield electrode on one principal plane; a fifth dielectric layer whose at least one principal plane is exposed outside; and a grounding electrode provided on the other principal plane of the above-described dielectric layer and/or the above-described one principal plane of the above-described fifth dielectric layer, and the above-described first grounding electrode and the above-described first shield electrode are electrically connected through a via hole provided in the above-described first dielectric layer.

Abstract: A mulitlayer ceramic device improves device functionality, reduces overall device size and profile, makes manufacturing easier, and improves reliability. A first ceramic layer 1 has a first multilayer circuit pattern 2 electrically connected through via holes 3. A second ceramic layer 2 also has a second multilayer circuit pattern 2 electrically connected through via holes 3. A thermosetting resin sheet 17 is disposed between the first and second ceramic layers. The thermosetting resin sheet has through holes filled with a conductive paste for electrically connecting one of multiple circuit pattern layers in the first ceramic layer with one of multiple circuit pattern layers in the second ceramic layer.

Abstract: The present invention provides a small and low loss laminated bandpass filter by placing two strip lines 313 and 314 that form a resonator in a certain distance on the same layer and thereby electromagnetically coupling these strip lines.

Abstract: A 3-frequency branching circuit in the past could not be used for a system wherein a TDMA method such as GSM and DCS and a W-CDMA method such as UMTS are mixed. The 3-frequency branching circuit equipped with branching means having first and second internal terminals 21 and 22, an antenna terminal 20 of connecting to an antenna, a low-pass filter connected between the first internal terminal 21 and the antenna terminal 20, and a high-pass filter connected between the second internal terminal 22 and the antenna terminal 20, a switching circuit 1 of switching between GSMTX and GSMRX, a switching circuit 2 of switching between DCS TX, DCS RX and a third internal terminal 23, and a duplexer connected to the third internal terminal 23.

Abstract: A multilayer ceramic device improves device functionality, reduces overall device size and profile, makes manufacturing easier, and improves reliability. A first ceramic layer has a first multilayer circuit pattern electrically connected through via holes. Also, a second ceramic layer has a second multilayer circuit pattern electrically connected through via holes. A thermosetting resin sheet is disposed between the first and second ceramic layers.

Abstract: A laminated filter includes: a first dielectric layer 2101a having a first shield electrode on one principal plane; a second dielectric layer 2101b having resonator electrodes on one principal plane; a third dielectric layer 2101c having a coupling electrode provided facing part of the above-described resonator electrodes; a fourth dielectric layer 2101d having a second shield electrode on one principal plane; a fifth dielectric layer 2101d whose at least one principal plane is exposed outside; and a grounding electrode 2108 provided on the other principal plane of the above-described dielectric layer and/or the above-described one principal plane of the above-described fifth dielectric layer, and the above-described first grounding electrode and the above-described first shield electrode are electrically connected through a via hole 2109 provided in the above-described first dielectric layer.

Abstract: A multilayer ceramic device improves device functionality, reduces overall device size and profile, makes manufacturing easier, and improves reliability. A first ceramic layer has a first multilayer circuit pattern electrically connected through via holes. Also, a second ceramic layer has a second multilayer circuit pattern electrically connected through via holes. A thermosetting resin sheet is disposed between the first and second ceramic layers. The thermosetting resin sheet has through holes filled with a conductive paste for electrically connecting one of multiple circuit pattern layers in the first ceramic layer with one of multiple circuit pattern layers in the second ceramic layer.

Abstract: The present invention provides a small and low loss laminated bandpass filter by placing two strip lines 313 and 314 that form a resonator in a certain distance on the same layer and thereby electromagnetically coupling these strip lines.

Abstract: (Object)