Abstract: The present invention provides a novel piperidine compound of the formula [I]: wherein Ring A represents an optionally substituted benzene ring, Ring B represents an optionally substituted benzene ring, R1 represents an optionally substituted alkyl group, an optionally substituted hydroxyl group, etc., or a group of the formula: (a) wherein R11 and R12 are the same or different, and each represents hydrogen atom, a substituted carbonyl group, a substituted sulfonyl group, an optionally substituted alkyl group, etc., R2 represents hydrogen atom, etc., Z represents oxygen atom or a group represented by —N(R3)—, R3 represents hydrogen atom or an alkyl group, etc., R4 represents hydrogen atom or an alkyl group, etc., or a pharmaceutically acceptable salt thereof.

Abstract: The present invention discloses a thiomorpholine compound represented by the formula [I]: wherein Ring A represents an optionally substituted benzene ring; Ring B represents an optionally substituted benzene ring; R1 represents hydrogen atom, an optionally substituted hydroxyl group, an optionally substituted amino group, an optionally substituted alkyl group, a substituted carbonyl group or a halogen atom; R2 represents hydrogen atom or an optionally substituted alkyl group; and R3a and R3b may be the same or different from each other, and each represent hydrogen atom or an optionally substituted alkyl group, or combined to each other at the both ends thereof to form an alkylene group, and n is an integer of 1 or 2, or a pharmaceutically acceptable salt thereof.

Abstract: The present invention is to provide a piperidine compound represented by the formula [I]: wherein Ring A is an optionally substituted benzene ring, Ring B is an optionally substituted benzene ring, R1 is hydrogen atom or a substituent for amino group, R2 is hydrogen atom, an optionally substituted hydroxyl group, an optionally substituted amino group, an optionally substituted alkyl group, a substituted carbonyl group or a halogen atom, Z is oxygen atom or —N(R3)—, R3 is hydrogen atom or an optionally substituted alkyl group, R4a and R4b may be the same or different, and each is hydrogen atom or an optionally substituted alkyl group, or may be bonded to each other at the both ends to form an alkylene group, or a pharmaceutically acceptable salt thereof, which has an excellent tachykinin receptor antagonistic action.

Abstract: The present invention relates to a piperidine compound represented by the formula [I]: wherein Ring A represents an optionally substituted benzene ring, Ring B represents an optionally substituted benzene ring, R1 represents an optionally substituted hydoxyl group, a substituted thiol group, a substituted sulfonyl group, etc., or a group represented by the formula: R11 represents a substituted carbonyl group or a substituted sulfonyl group, R12 represents hydrogen atom or an optionally substituted alkyl group, R2 represents hydrogen atom, etc., Z represent oxygen atom or a group represented by —N(R3)—, R3 represents an optionally substituted alkyl group, etc., R4a represents an optionally substituted alkyl group, R4b represents an optionally substituted alkyl group, or a pharmaceutically acceptable salt thereof, having an excellent tachykinin receptor antagonistic action.

Abstract: The present invention is to provide a piperidine compound represented by the formula [I]: wherein Ring A is an optionally substituted benzene ring, Ring B is an optionally substituted benzene ring, R1 is hydrogen atom or a substituent for amino group, R2 is hydrogen atom, an optionally substituted hydroxyl group, an optionally substituted amino group, an optionally substituted alkyl group, a substituted carbonyl group or a halogen atom, Z is oxygen atom or —N(R3)—, R3 is hydrogen atom or an optionally substituted alkyl group, R4a and R4b may be the same or different, and each is hydrogen atom or an optionally substituted alkyl group, or may be bonded to each other at the both ends to form an alkylene group, or a pharmaceutically acceptable salt thereof, which has an excellent tachykinin receptor antagonistic action.

Abstract: Disclosed are a novel piperidine compound represented by the general formula [I] below which has an excellent tachykinin receptor antagonizing activity and pharmacologically acceptable salts thereof. [I] In the formula, ring A represents an optionally substituted benzene ring; ring B represents an optionally substituted benzene ring; R1 represents an optionally substituted hydroxyl group, a thiol group having a substituent, a sulfonyl group having a substituent, or a group represented by the following formula [II]: wherein R11 represents a carbonyl group having a substituent or a sulfonyl group having a substituent and R12 represents a hydrogen atom or an optionally substituted alkyl group; R2 represents a hydrogen atom or the like; Z represents an oxygen atom or a group represented by —N(R3)— wherein R3 represents an optionally substituted alkyl group or the like; R4a represents an optionally substituted alkyl group; and R4b represents an optionally substituted alkyl group.

Abstract: The present invention relates to a 5-phenylbenzylamine compound represented by the formula [1]: wherein Ring A represents a phenyl group having a substituent(s), Ra, Rb1 and Rb2 each represent hydrogen atom, a halogen atom, a lower alkyl group, a halogeno-lower alkyl group or a lower alkoxy group, Rc1 represents hydrogen atom, a lower alkyl group optionally substituted by a heterocyclic group, or an acyl group, Rc2 and Re each represent hydrogen atom or a lower alkyl group, Rd represents hydrogen atom, a lower alkyl group or an acyl group, and Rf represents a lower alkyl group or a cyclic lower alkyl group, or a pharmaceutically acceptable salt thereof, a process for preparing the same and synthetic intermediate thereof.

Abstract: The present invention provides a novel piperidine compound of the formula [I]: wherein Ring A represents an optionally substituted benzene ring, Ring B represents an optionally substituted benzene ring, R1 represents an optionally substituted alkyl group, an optionally substituted hydroxyl group, etc., or a group of the formula: (a) wherein R11 and R12 are the same or different, and each represents hydrogen atom, a substituted carbonyl group, a substituted sulfonyl group, an optionally substituted alkyl group, etc., R2 represents hydrogen atom, etc., Z represents oxygen atom or a group represented by —N(R3)—, R3 represents hydrogen atom or an alkyl group, etc., R4 represents hydrogen atom or an alkyl group, etc., or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to a 5-phenylbenzylamine compound represented by the formula [1]: 1

Abstract: There is provided a hose for fuel piping which has an inner layer portion having a single layer of a thermoplastic resin having a low fuel permeability, the inner layer portion has a thickness of at least 0.3 mm at a maximum thickness portion, and an outer layer portion of a thermoplastic elastomer. The inner layer portion is laminated to the outer layer portion by a bond strength of 0.6 kgf/cm or less. In a modification, the inner layer portion of a thermoplastic resin having a low fuel permeability can be coated with a thermoplastic resin.

Abstract: A transfer machine and system is disclosed which automatically performs a series of marking, cutting, sorting, and the like operations in the manufacture of a large number of test material samples. The transfer machine operates under the control of a card or tape reader which provides coded information such as marking indicia, pattern number and thickness of the material for each test sample. This information is encoded, temporarily stored and then shifted in a series of parallel shift registers in sequence with the corresponding test sample as it progresses through each stage of the transfer machine. The contents of the shift registers at each stage are decoded to provide the control signals for the corresponding marking, cutting, sorting, and similar operations.