Abstract: Disclosed is a method for producing a fusion protein in which an antibody and a lysosomal enzyme are fused. The method is a method for producing a fusion protein in which an antibody and a human lysosomal enzyme are fused, the method including: (a) culturing mammalian cells producing the fusion protein in a serum-free medium to secrete the fusion protein in a culture medium; (b) collecting a culture supernatant by removing the mammalian cells from the culture medium; and (c) purifying the fusion protein from the culture supernatant by using a column chromatography using a material to which a substance having affinity for the antibody is bound as a solid phase, an anion exchange column chromatography, a cation exchange column chromatography, and a size exclusion column chromatography.

Abstract: Disclosed is a method for producing a fusion protein of human serum albumin and human growth hormone. The method comprises (a) a step of culturing a mammalian cell capable of producing the protein in a serum-free medium and causing the protein to be secreted into the culture fluid, (b) a step of collecting a culture supernatant by removing the mammalian cell from the culture fluid, and (c) a step of purifying the protein from the culture supernatant by using column chromatography using a material to which an antibody having an affinity for the protein is bound as a stationary phase, column chromatography using a material having an affinity for phosphate group as a stationary phase, cation exchange column chromatography, and size exclusion column chromatography.

Abstract: A battery-operated object detecting device (D) includes a detecting unit (U) adapted to be driven by an electric cell (12) mounted thereon, and a transmitting device (20) driven by the electric cell (12) in the detecting unit (U) for wireless transmitting at least a low battery signal being indicative of a reduction in voltage of the electric cell (12). An electric power sharing unit (30) for outputting a supply voltage to the transmitting device (20) includes a voltage changing circuit (32) for changing, based on a low battery detection result from a low battery detecting circuit (13), to a voltage necessary for causing a low battery determining circuit (21) of the transmitting device (20) to change the supply voltage from the electric cell (12) to a voltage for determining a low battery state.

Abstract: A suction tool for an electric cleaner of the present invention includes suction tool main body with suction inlet, rotary brush rotatably provided inside suction tool main body, brush body provided protruding from an outer periphery of rotary brush, and friction body rotatably provided to come into contact with brush body. This improves durability of brush body, and enables stable supply of negative ions to a cleaning surface.

Abstract: To provide an anti-thief security sensor assembly wherein an optical axis of a beam projecting unit can be accurately aligned with that of a beam receiving unit, the anti-thief security sensor assembly includes a beam projecting unit 1 for projecting an infrared beam IR and a beam receiving unit 8 for receiving the infrared beam IR. The beam projecting unit 1 includes a projector cover 21A detachably mounted on a mounting base 20A for enclosing and protecting a sensor circuit on the mounting base 20A, an opening detecting switch 7 for detecting a physical opening of the projector cover 21A, and a projected beam suppressing circuit 4 operable in response to detection by the opening detecting switch 7 to reduce a quantity of the infrared beam emitted from the beam projecting unit 1 to thereby reproduce the infrared beam of a quantity substantially equal to that having passed through the projector cover 21A.

Abstract: To provide an anti-thief security sensor assembly wherein an optical axis adjustment of a beam projector can be accurately achieved merely by physically opening a cover of a beam projecting unit while a cover of a beam receiving unit is not opened physically, the anti-thief security sensor assembly includes a beam projecting unit (1) for emitting an infrared beam IR and having a projector cover (21A) mounted on a projector base (20A) so as to cover and protect a sensor circuit. This beam projecting unit (1) includes an opening detecting switch (7) for detecting the physical opening of the projector cover (21A) and a transmission request generating circuit (8) operable in response to the detection by the opening detecting switch (7) to output a received beam level transmission request signal B to the beam receiving unit (2).

Abstract: To provide an anti-thief security sensor assembly wherein an optical axis of a beam projecting unit can be accurately aligned with that of a beam receiving unit, the anti-thief security sensor assembly includes a beam projecting unit 1 for projecting an infrared beam IR and a beam receiving unit 8 for receiving the infrared beam IR. The beam projecting unit 1 includes a projector cover 21A detachably mounted on a mounting base 20A for enclosing and protecting a sensor circuit on the mounting base 20A, an opening detecting switch 7 for detecting a physical opening of the projector cover 21A, and a projected beam suppressing circuit 4 operable in response to detection by the opening detecting switch 7 to reduce a quantity of the infrared beam emitted from the beam projecting unit 1 to thereby reproduce the infrared beam of a quantity substantially equal to that having passed through the projector cover 21A.

Abstract: To provide an anti-thief security sensor assembly wherein an optical axis adjustment of a beam projector can be accurately achieved merely by physically opening a cover of a beam projecting unit while a cover of a beam receiving unit is not opened physically, the anti-thief security sensor assembly includes a beam projecting unit (1) for emitting an infrared beam IR and having a projector cover (21A ) mounted on a projector base (20A) so as to cover and protect a sensor circuit. This beam projecting unit (1) includes an opening detecting switch (7) for detecting the physical opening of the projector cover (21A) and a transmission request generating circuit (8) operable in response to the detection by the opening detecting switch (7) to output a received beam level transmission request signal B to the beam receiving unit (2).

Abstract: An X-ray computed tomography apparatus in which detection signals based on X-rays transmitted through an object to be examined are repeatedly integrated at predetermined intervals. The integral signal is sampled a plurality of times in an initial period of the interval, and the sampled signals are averaged. The integral signal is also sampled a plurality of times in a final period of the interval, and the sampled signals are averaged. Projection data are created by subtracting the initial average value from the final average value. Circuit noise can be reduced according to the increase in number of times of sampling with a detioration in X-rays available for processing since the integration time is substantially shortened. Circuit noise becomes conspicuous when the dose of transmitted X-rays is relatively small, and becomes latent when the dose of X-rays is relatively large.

Abstract: Disclosed is:i) a nitride type ceramic substrate comprises; a nitride type ceramic sintered sheet; a conductive metallized layer formed on the nitride type ceramic sintered sheet; and a layer of a compound containing yttria and alumina, present in the vicinity of the interface between the nitride type ceramic sintered sheet and the metallized layer;ii) a circuit substrate comprises; a substrate comprising a nitride type ceramic sintered sheet; a metallized layer comprising molybdenum and tungsten as a main component and an activation metal added thereto formed on the substrate; and a layer of a compound containing yttria and alumina, present inside of the metallized layer and in the vicinty of the interface between the substrate and the metallized layer;iii) a surface conductive ceramic substrate which is characterized by comprising; a nitride type ceramic substrate; and a conductive metallized layer chiefly comprised of at least one of Mo and W, a group IVa active metal element and a fourth period transition

Abstract: One aspect of the present invention is directed to an aluminum nitride ceramic substrate which comprises an aluminum nitride ceramic sheet and a conductive metallized layer formed thereon. The metallized layer comprises molybdenum and/or tungsten and contains a compound containing yttria and alumina in the vicinity of the interface between the aluminum nitride ceramic sintered sheet and the conductive metallized layer.

Abstract: A suction nozzle assembly for a vacuum cleaner, which has a suction spout having a coupling stem for fluid-connection with the vacuum cleaner, a generally rectangular nozzle housing tiltably connected with the suction spout and having a sweeping surface defined at the bottom thereof and adapted to confront a surface to be cleaned, an elongated brush assembly carried by the nozzle housing for movement between projected and retracted positions in a direction perpendicular to the longitudinal sense of the housing through the sweeping surface, a brush height adjustment device for adjustably moving the brush assembly to any one of the projected and retracted positions, and a restraint device for restraining the housing from undergoing an arbitrary tilting motion relative to the suction spout.