Abstract: Systems and methods for designing and fabricating three-dimensional objects with precisely computed material compositions for use in enhancing electromagnetic fields for magnetic resonance imaging (“MRI”) are provided. As examples, the fabricated object can be designed to reduce magnetic field inhomogeneities in the main magnetic field of an MRI system, or to reduce inhomogeneities in a transmit radio frequency (“RF”) field (i.e., a B1 field). As examples, the object can be a shim; a housing or other part of an RF coil; a medical device, such as a surgical implant; or component used in a medical device, such as a housing for an implantable medical device.

Abstract: Methods for the diagnosis and treatment of ischemic spinal conditions, degenerative disc disease, back pain and/or other tissue pathologies. Patients with ischemic spine disease can be categorized into subsets that are deemed to have potential to respond to therapy. In particular, therapies are disclosed which involve stimulation of neovascularization so as to increase perfusion of spinal and other anatomies.

Abstract: The invention relates to systems and methods for the diagnosis, amelioration, and treatment of ischemic tissues in patients caused by and/or resulting from diminished microvascular blood flow. Patients suffering from ischemic tissue conditions can be categorized into specific subsets that are deemed to have a potential to respond to therapy. In particular, the invention includes various therapies involving stimulation of angiogenesis, vasculogenesis, arteriogenesis and/or neovascularization so as to increase perfusion of various tissues.

Abstract: Systems and methods for performing diffusion-weighted multi-spectral imaging (“MS!”) with a magnetic resonance imaging (“MRI”) system are provided, Diffusion-weighted images can thus be acquired from a subject in which a metallic object, such as an implant or other device, is present. In general, a two-dimensional or three-dimensional diffusion-weighted PROPELLER acquisition is performed to acquire data from multiple different spectral bins. Images from the spectral bins are reconstructed and combined to form diffusion-weighted composite images. Non-CPMG phase-cycling and split-blade PROPELLER techniques are combined with PROPELLER MSI metal artifact mitigation principles to this end.

Abstract: The invention relates to systems and methods for the diagnosis, amelioration, and treatment of ischemic tissues in patients caused by and/or resulting from diminished microvascular blood flow. Patients suffering from ischemic tissue conditions can be categorized into specific subsets that are deemed to have a potential to respond to therapy. In particular, the invention includes various therapies involving stimulation of angiogenesis, vasculogenesis, arteriogenesis and/or neovascularization so as to increase perfusion of various tissues.

Abstract: Systems and methods for performing diffusion-weighted multi-spectral imaging (“MS!”) with a magnetic resonance imaging (“MRI”) system are provided, Diffusion-weighted images can thus be acquired from a subject in which a metallic object, such as an implant or other device, is present. In general, a two-dimensional or three-dimensional diffusion-weighted PROPELLER acquisition is performed to acquire data from multiple different spectral bins. Images from the spectral bins are reconstructed and combined to form diffusion-weighted composite images. Non-CPMG phase-cycling and split-blade PROPELLER techniques are combined with PROPELLER MSI metal artifact mitigation principles to this end.

Abstract: A method for highly accelerated projection imaging (“HAPI”) is provided. In this method, conventional linear gradients are used to obtain coil sensitivity-weighted projections of the object being imaged. Only a relatively small number of projections, such as sixteen or less, of the object are required to reconstruct a two-dimensional image of the object, unlike conventional projection imaging techniques. The relationship between the voxel values of the imaged object and the coil sensitivity-weighted projections is formulated as a linear system of equations and the reconstructed images are obtained by solving this matrix equation. This method advantageously allows higher acceleration rates compared to echo planar imaging (“EPI”) with SENSE or GRAPPA acceleration. Moreover, the method does not require any additional or specialized hardware because hardware in conventional MRI scanners is adequate to implement the method.

Abstract: The invention relates to systems and methods for the diagnosis, amelioration, and treatment of ischemic tissues in patients caused by and/or resulting from diminished microvascular blood flow. Patients suffering from ischemic tissue conditions can be categorized into specific subsets that are deemed to have a potential to respond to therapy. In particular, the invention includes various therapies involving stimulation of angiogenesis, vasculogenesis, arteriogenesis and/or neovascularization so as to increase perfusion of various tissues.

Abstract: A method for highly accelerated projection imaging (“HAPI”) is provided. In this method, conventional linear gradients are used to obtain coil sensitivity-weighted projections of the object being imaged. Only a relatively small number of projections, such as sixteen or less, of the object are required to reconstruct a two-dimensional image of the object, unlike conventional projection imaging techniques. The relationship between the voxel values of the imaged object and the coil sensitivity-weighted projections is formulated as a linear system of equations and the reconstructed images are obtained by solving this matrix equation. This method advantageously allows higher acceleration rates compared to echo planar imaging (“EPI”) with SENSE or GRAPPA acceleration. Moreover, the method does not require any additional or specialized hardware because hardware in conventional MRI scanners is adequate to implement the method.

Abstract: The invention relates to methods for the diagnosis, amelioration, and treatment of back pain, particularly lumbar back pain, in particular, back pain caused by muscular abnormalities, vertebral body osteoporosis, and disc degeneration. Patients with back pain are categorized into specific subsets that are deemed to have potential to respond to therapy. In particular, the invention includes a therapy involving stimulation of neovascularization so as to increase perfusion of various spine compartments.

Abstract: Methods for the diagnosis and treatment of ischemic spinal conditions, degenerative disc disease, back pain and/or other tissue pathologies. Patients with ischemic spine disease can be categorized into subsets that are deemed to have potential to respond to therapy. In particular, therapies are disclosed which involve stimulation of neovascularization so as to increase perfusion of spinal and other anatomies.

Abstract: The invention relates to methods for the diagnosis, amelioration, and treatment of back pain, particularly lumbar back pain, in particular, back pain caused by muscular abnormalities, vertebral body osteoporosis, and disc degeneration. Patients with back pain are categorized into specific subsets that are deemed to have potential to respond to therapy. In particular, the invention includes a therapy involving stimulation of neovascularization so as to increase perfusion of various spine compartments.