Patents by Inventor Tuomo Nikula

Tuomo Nikula has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11351395
    Abstract: A method for producing a model for the application of radiation to a body surface area of a living being for cosmetic or therapeutic purposes is provided. The method includes defining a body surface area to which radiation shall be applied; producing a model having at least one surface which has the inverted shape of the defined body surface area, so that the model is configured to fit on the defined body surface area; and providing a radioactive isotope to the model during its production or after its production. Further, the use of the model in a cosmetic treatment of the skin is provided. The model, for cosmetic or therapeutic purposes, includes a surface which has the inverted shape of a defined body surface area which shall be treated with radiation.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: June 7, 2022
    Assignee: ONCOBETA INTERNATIONAL GMBH
    Inventors: Tuomo Nikula, Thomas Wendler, Juho Nikula
  • Patent number: 11135323
    Abstract: Provided is a process of producing activated particles comprising 188Re-isotopes and/or 186Re-isotopes by irradiating non-volatile and water-insoluble starting particles comprising a rhenium compound with neutrons. Further provided is a process of producing corresponding non-volatile and water-insoluble starting particles. Further provided are respective starting particles and activated particles, respectively, and a composition comprising a plurality of activated particles. The activated particles, and the composition comprising same are suitable for use in radionuclide therapy, and for cosmetic applications.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: October 5, 2021
    Assignee: ONCOBETA INTERNATIONAL GMBH
    Inventors: Tuomo Nikula, Thomas Wendler
  • Publication number: 20200030631
    Abstract: A method for producing a model for the application of radiation to a body surface area of a living being for cosmetic or therapeutic purposes is provided. The method includes defining a body surface area to which radiation shall be applied; producing a model having at least one surface which has the inverted shape of the defined body surface area, so that the model is configured to fit on the defined body surface area; and providing a radioactive isotope to the model during its production or after its production. Further, the use of the model in a cosmetic treatment of the skin is provided. The model, for cosmetic or therapeutic purposes, includes a surface which has the inverted shape of a defined body surface area which shall be treated with radiation.
    Type: Application
    Filed: February 9, 2018
    Publication date: January 30, 2020
    Inventors: Tuomo Nikula, Thomas Wendler, Juho Nikula
  • Publication number: 20190290789
    Abstract: Provided is a process of producing activated particles comprising 188Re-isotopes and/or 186Re-isotopes by irradiating non-volatile and water-insoluble starting particles comprising a rhenium compound with neutrons. Further provided is a process of producing corresponding non-volatile and water-insoluble starting particles. Further provided are respective starting particles and activated particles, respectively, and a composition comprising a plurality of activated particles. The activated particles, and the composition comprising same are suitable for use in radionuclide therapy, and for cosmetic applications.
    Type: Application
    Filed: October 10, 2017
    Publication date: September 26, 2019
    Inventors: Tuomo Nikula, Thomas Wendler
  • Patent number: 9816156
    Abstract: The present invention relates to a column chromatographic method of manufacturing non-carrier-added high-purity 177Lu compounds for medicinal purposes. In the method in accordance with the invention a cation exchanger and a suitable chelating agent are used. With the method in accordance with the invention it is possible for the first time to provide non-carrier-added high-purity 177Lu compounds in milligram amounts for pharmaceutical-medicinal purposes from 176Yb compounds irradiated with thermal neutrons, the radionuclides 177Lu and 176Yb being present in an approximate mass ratio of 1:102 to 1:1010 for purification.
    Type: Grant
    Filed: April 12, 2012
    Date of Patent: November 14, 2017
    Assignee: ITM Isotopen Technologien München AG
    Inventors: Sebastian Marx, Mark Harfensteller, Konstantin Zhernosekov, Tuomo Nikula
  • Patent number: 9802969
    Abstract: Molecule for attaching a radioactive parent nuclide to a support, comprising at least one functional group for attaching the radioactive parent nuclide; and a molecular moiety suitable for establishing a nonpolar bond to the support.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: October 31, 2017
    Assignee: ITM Isotopen Technologien Munchen AG
    Inventors: Konstantin Zhernosekov, Tuomo Nikula
  • Publication number: 20160009742
    Abstract: Molecule for attaching a radioactive parent nuclide to a support, comprising at least one functional group for attaching the radioactive parent nuclide; and a molecular moiety suitable for establishing a nonpolar bond to the support.
    Type: Application
    Filed: September 18, 2015
    Publication date: January 14, 2016
    Inventors: Konstantin ZHERNOSEKOV, Tuomo NIKULA
  • Patent number: 9142328
    Abstract: Molecule for attaching a radioactive parent nuclide to a support, comprising at least one functional group for attaching the radioactive parent nuclide; and a molecular moiety suitable for establishing a nonpolar bond to the support.
    Type: Grant
    Filed: February 4, 2010
    Date of Patent: September 22, 2015
    Assignee: ITM ISOTOPEN TECHNOLOGIEN MÜNCHEN AG
    Inventors: Konstantin Zhernosekov, Tuomo Nikula
  • Patent number: 8937166
    Abstract: The present invention relates to a 68Ga generator, wherein the 68Ge parent nuclide thereof is attached specifically to a support through a triethoxyphenyl group and continuously disintegrates to 68Ga, the triethoxyphenyl group being covalently bound to a support material through a linker.
    Type: Grant
    Filed: June 27, 2013
    Date of Patent: January 20, 2015
    Assignee: ITM Isotopen Technologien Munchen AG
    Inventors: Konstantin Zhernosekov, Tuomo Nikula
  • Publication number: 20140294700
    Abstract: The present invention relates to a column chromatographic method of manufacturing non-carrier-added high-purity 177Lu compounds for medicinal purposes. In the method in accordance with the invention a cation exchanger and a suitable chelating agent are used. With the method in accordance with the invention it is possible for the first time to provide non-carrier-added high-purity 177Lu compounds in milligram amounts for pharmaceutical-medicinal purposes from 176Yb compounds irradiated with thermal neutrons, the radionuclides 177Lu and 176Yb being present in an approximate mass ratio of 1:102 to 1:1010 for purification.
    Type: Application
    Filed: April 12, 2012
    Publication date: October 2, 2014
    Applicant: ITM ISOTOPEN TECHNOLOGIEN MÜNCHEN AG
    Inventors: Sebastian Marx, Mark Harfensteller, Konstantin Zhernosekov, Tuomo Nikula
  • Publication number: 20140163211
    Abstract: The present invention relates to a 68Ga generator, wherein the 68Ge parent nuclide thereof is attached specifically to a support through a triethoxyphenyl group and continuously disintegrates to 68Ga, the triethoxyphenyl group being covalently bound to a support material through a linker.
    Type: Application
    Filed: June 27, 2013
    Publication date: June 12, 2014
    Applicant: ITM Isotopen Technologien München AG
    Inventors: Konstantin Zhernosekov, Tuomo Nikula
  • Patent number: 8487047
    Abstract: The present invention relates to a 68Ga generator, wherein the 68Ge parent nuclide thereof is attached specifically to a support through a triethoxyphenyl group and continuously disintegrates to 68Ga, the triethoxyphenyl group being covalently bound to a support material through a linker.
    Type: Grant
    Filed: September 28, 2011
    Date of Patent: July 16, 2013
    Assignee: ITM Isotopen Technologien Munchen AG
    Inventors: Konstantin Zhernosekov, Tuomo Nikula
  • Patent number: 8403906
    Abstract: A therapy module for providing a diagnostic or therapeutic substance combination, including at least two containers adapted to be interconnected for taking up at least one substance, and means or part of a means for supplying a quantity of the at least one substance from one of the containers into another container of the therapy module.
    Type: Grant
    Filed: April 4, 2006
    Date of Patent: March 26, 2013
    Assignee: Isotopen Technologien Munchen AG
    Inventors: Oliver Buck, Christoph Ehlers, Tuomo Nikula, Michael Schilp
  • Publication number: 20120252981
    Abstract: The present invention relates to a 68Ga generator, wherein the 68Ge parent nuclide thereof is attached specifically to a support through a triethoxyphenyl group and continuously disintegrates to 68Ga, the triethoxyphenyl group being covalently bound to a support material through a linker.
    Type: Application
    Filed: September 28, 2011
    Publication date: October 4, 2012
    Inventors: Konstantin Zhernosekov, Tuomo Nikula
  • Publication number: 20100202915
    Abstract: Molecule for attaching a radioactive parent nuclide to a support, comprising at least one functional group for attaching the radioactive parent nuclide; and a molecular moiety suitable for establishing a nonpolar bond to the support.
    Type: Application
    Filed: February 4, 2010
    Publication date: August 12, 2010
    Inventors: Konstantin Zhernosekov, Tuomo Nikula
  • Patent number: 7605384
    Abstract: The invention relates to an apparatus for preparing a small amount of a radioactive substance combination, including a one-part body, a mixing device integrated in the body and adapted to receive a small amount of chemical substances, and at least one receptacle integrated in the body and connected to the mixing device and adapted to hold a small amount of a chemical substance.
    Type: Grant
    Filed: May 11, 2006
    Date of Patent: October 20, 2009
    Assignee: Isotopen Technologien Munchen AG
    Inventors: Julian Bernd Sonnenhol, Andreas Eursch, Mark Harfensteller, Michael Schilp, Oliver Buck, Lisa Maria Ehrenfried, Tuomo Nikula
  • Publication number: 20080224072
    Abstract: The invention relates to an apparatus for preparing a small amount of a radioactive substance combination, including a one-part body, a mixing device integrated in the body and adapted to receive a small amount of chemical substances, and at least one receptacle integrated in the body and connected to the mixing device and adapted to hold a small amount of a chemical substance.
    Type: Application
    Filed: May 11, 2006
    Publication date: September 18, 2008
    Applicant: Isotopen Technologien Munchen AG
    Inventors: Julian Bernd Sonnenhol, Andreas Eursch, Mark Harfensteller, Michael Schilp, Oliver Buck, Lisa Maria Ehrenfried, Tuomo Nikula
  • Publication number: 20080140046
    Abstract: A therapy module for providing a diagnostic or therapeutic substance combination, including at least two containers adapted to be interconnected for taking up at least one substance, and means or part of a means for supplying a quantity of the at least one substance from one of the containers into another container of the therapy module.
    Type: Application
    Filed: April 4, 2006
    Publication date: June 12, 2008
    Applicant: Isotopen Technologien Munchen AG
    Inventors: Oliver Buck, Christoph Ehlers, Tuomo Nikula, Michael Schilp
  • Publication number: 20060198772
    Abstract: A method for producing Ac-225 is presented, wherein Ac-225 is produced by bombardment of Ra-226 with deuterons accelerated in a cyclotron. The deuterons preferably have an incident energy of between 15 and 22 MeV. The method, which allows production of Ac-225 at high yields and purity levels, is particularly interesting in view of Bi-213 generation.
    Type: Application
    Filed: March 5, 2004
    Publication date: September 7, 2006
    Inventors: Kamel Abbas, Christos Apostolidis, Willem Janssens, Hermann Stamm, Tuomo Nikula, Ramon Carlos-Marquez
  • Publication number: 20050008553
    Abstract: The invention relates to a method of loading a mother radionuclide into a radionuclide generator which comprises an cation exchange material, the said method comprising a preliminary step which consists in passing over said material a solution containing the mother radionuclide and a complexing agent for said radionuclide, said complexing agent being at an effective concentration so as to prevent the mother radionuclide from concentrating solely in one part of the volume of the cation exchange material, the cation exchange material being chosen in the group consisting of the macroporous resins and the resins having a crosslinking rate of from 1 to 12%. This method is applied to radioisotope generators which emit ? particles and are used in particular in the field of radiotherapy.
    Type: Application
    Filed: May 19, 2004
    Publication date: January 13, 2005
    Applicant: The European Atomic Energy Community (EURATOM)
    Inventors: Christos Apostolidis, Bruno Brandalise, Ramon Carlos-Marquez, Willem Janssens, Roger Molinet, Tuomo Nikula