Patents by Inventor Tuula Koskelainen

Tuula Koskelainen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alpha2 adrenoceptor agonists
    Patent number: 9249127
    Abstract: Compounds of formula (I), wherein X and R1-R6, are as defined in the claims, exhibit alpha2 agonistic activity and thus are useful as alpha2 agonists, especially as alpha2A agonists. Methods of use of said compounds are also provided.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: February 2, 2016
    Assignee: ORION CORPORATION
    Inventors: Tuula Koskelainen, Tero Linnanen, Anna Minkkilä, Mikko Mäkelä, Antti Pohjakallio
  • NEW ALPHA2 ADRENOCEPTOR AGONISTS
    Publication number: 20150065550
    Abstract: Compounds of formula (I), wherein X and R1-R6, are as defined in the claims, exhibit alpha2 agonistic activity and thus are useful as alpha2 agonists, especially as alpha2A agonists. Methods of use of said compounds are also provided.
    Type: Application
    Filed: March 28, 2013
    Publication date: March 5, 2015
    Inventors: Tuula Koskelainen, Tero Linnanen, Anna Minkkilä, Mikko Mäkelä, Antti Pohjakallio
  • Pyridine derivatives useful for inhibiting sodium/calcium exchange system
    Patent number: 7482340
    Abstract: Therapeutically active compounds of formula (I) or (II): wherein the variables in formulas (I) and (II) are defined in the description, and pharmaceutically acceptable salts and esters thereof. The compounds are potent inhibitors of Na+/Ca2+ exchange mechanism.
    Type: Grant
    Filed: January 9, 2004
    Date of Patent: January 27, 2009
    Assignee: Orion Corporation
    Inventors: Leena Otsomaa, Tuula Koskelainen, Arto Karjalainen, Sirpa Rasku, Piero Pollesello, Jouko Levijoki
  • Compounds, which are potent inhibitors of Na /Ca exchange mechanism and are useful in the treatment of arrhythmias
    Patent number: 7425568
    Abstract: Therapeutically active compounds of formula (I): wherein the variables shown in formula (I) are defined in the disclosure; and pharmaceutically acceptable salts and esters thereof. The compounds are potent inhibitors of the Na+/Ca2+ exchange mechanism.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: September 16, 2008
    Assignee: Orion Corporation
    Inventors: Tuula Koskelainen, Leena Otsomaa, Arto Karjalainen, Pekka Kotovuori, Jukka Tenhunen, Sirpa Rasku, Pentti Nore, Eija Tiainen, Olli Törmäkangas
  • Pyridine derivatives useful for inhibiting sodium/calcium exchange system
    Publication number: 20060241147
    Abstract: Therapeutically active compounds of formula (I) or (II): wherein the variables in formulas (I) and (II) are defined in the description, and pharmaceutically acceptable salts and esters thereof. The compounds are potent inhibitors of Na+/Ca2+ exchange mechanism.
    Type: Application
    Filed: January 9, 2004
    Publication date: October 26, 2006
    Inventors: Leena Otsomaa, Tuula Koskelainen, Arto Karjalainen, Sirpa Rasku, Piero Pollesello, Jouko Levijoki
  • Compounds, which are potent inhibitors of na+ / ca2+ exchange mechanism and are useful in the treatment of arrhythmias
    Publication number: 20040235905
    Abstract: Therapeutically active compounds of formula (I): wherein X is —O—, —CH2— or —C(O)—; Z is —CHR9— or valence bond; Y is —CH2—, —C(O)—, CH(OR10)—, —CH(NR11R12)—, —O—, —S—, —S(O)— or —S(O2)—, provided that in case Z is a valence bond, Y is not C(O); the dashed line represents an optional double bond in which case Z is —CR9— and Y is —CH—, C(OR10)— or —C(NR11R12)—; R1 is —(CH2)nNR4R7 or one of the following groups: n is 1-4; R2 and R3 are independently H, lower alkyl, lower alkoxy, —NO2, halogen, —CF3, —OH, —NHR8 or —COOH, R4 and R7 are independently H, lower alkyl or lower hydroxyalkyl; R5 is H, lower alkoxy, —CF3, —NH2 or —CN; R6 is —NO2, —NR14R19, —CF3 or R8 and R16 are independently H or acyl; R9 is H or lower alkyl; R10 is H, alkylsulfonyl or acyl; R11 and R12 a
    Type: Application
    Filed: June 8, 2004
    Publication date: November 25, 2004
    Inventors: Tuula Koskelainen, Leena Otsomaa, Arto Karjalainen, Pekka Kotovuori, Jukka Tenhunen, Sirpa Rasku, Pentti Nore, Eija Tiainen, Olli Tormakangas