Abstract: Disclosed is an implant and method of making an implant. The implant having a housing that defines a cavity. The housing includes a sensor comprising a base attached to a diaphragm wherein said base may be positioned within said cavity. The sensor may be a capacitive pressure sensor. The diaphragm may be connected to the housing to hermetically seal said housing. The sensor may include electrical contacts positioned on the diaphragm. The attachment between the base and the diaphragm may define a capacitive gap and at least one discontinuity configured to enhance at least one performance parameter of said implant.

Abstract: Provided herein is a catheter lock. The catheter lock includes a hub having a first axial extension, a second axial extension, and an intersecting opening with at least one hub feature formed on an inner surface thereof; a button having an outer surface mirroring the inner surface of the intersecting opening and at least one button feature formed thereon, an elongated transverse opening, a cutout section extending along the outer surface of the button, and a hole in a top portion thereof; and a locking article configured to extend through the first axial extension, along the cutout section, and through the hole. The button is arranged and disposed to slide within the intersecting opening of the hub, and the at least one button feature is arranged and disposed to engage one of the at least one hub features. Also provided herein are an axial catheter lock and a locking catheter.

Abstract: Disclosed is an implant and method of making an implant. The implant having a housing that defines a cavity. The housing includes a sensor comprising a base attached to a diaphragm wherein said base may be positioned within said cavity. The sensor may be a capacitive pressure sensor. The diaphragm may be connected to the housing to hermetically seal said housing. The sensor may include electrical contacts positioned on the diaphragm. The attachment between the base and the diaphragm may define a capacitive gap and at least one discontinuity configured to enhance at least one performance parameter of said implant.

Abstract: An injection device includes an injector body. The injection device also includes a cartridge coupled to the injector body and having a first height and comprising an orifice. The injector device also includes a cap coupled to the injector body having a second height and including an outer rim, wherein the outer rim surrounds the cartridge, and wherein the first height is greater than the second height.

Abstract: An eye drop applicator includes an applicator body with a top cavity, a bottom cavity, and a dispensing channel connecting the bottom cavity with the top cavity such that a fluid can selectively flow through the dispensing channel to the top cavity. The top cavity includes an opening at a top end of the applicator body, and the bottom cavity includes a bottom opening at a bottom end of the applicator body. The bottom cavity may receive a portion of an applicator container within the bottom cavity to assemble the eye drop applicator with the applicator container containing the fluid to be dispensed.

Abstract: An injection system includes an injector device and a base station. The injector device includes a cartridge. The injector device additionally includes an injector body coupled to the cartridge at a first end of the injector body, the injector body including a plug at a second end of the injector body. The injector device further includes a spring coupled to the cartridge. The base station is configured to electrically couple to the plug, wherein the base station comprises a motor. Rotation of the motor transmits power to the injector device compressing the spring and drawing medicine from a vial into the cartridge.

Abstract: An injection system includes an injector device and a base station. The injector device includes a cartridge. The injector device further includes an injector body coupled to the cartridge at a first end of the injector body, the injector body comprising a plug at a second end of the injector body. The base station is configured to couple to the plug, wherein the base station comprises a motor, and wherein rotation of the motor draws medicine from a vial into the cartridge, and wherein a volume of the medicine drawn from the vial into the cartridge is in excess of an set dosage.

Abstract: Disclosed is an implant and method of making an implant. The implant having a housing that defines a cavity. The housing includes a sensor comprising a base attached to a diaphragm wherein said base may be positioned within said cavity. The sensor may be a capacitive pressure sensor. The diaphragm may be connected to the housing to hermetically seal said housing. The sensor may include electrical contacts positioned on the diaphragm. The attachment between the base and the diaphragm may define a capacitive gap and at least one discontinuity configured to enhance at least one performance parameter of said implant.

Abstract: An eye drop applicator includes an applicator body with a top cavity, a bottom cavity, and a dispensing channel connecting the bottom cavity with the top cavity such that a fluid can selectively flow through the dispensing channel to the top cavity. The top cavity includes an opening at a top end of the applicator body, and the bottom cavity includes a bottom opening at a bottom end of the applicator body. The bottom cavity may receive a portion of an applicator container within the bottom cavity to assemble the eye drop applicator with the applicator container containing the fluid to be dispensed.

Abstract: Disclosed is an implant and method of making an implant. The implant having a housing that defines a cavity. The housing includes a sensor comprising a base attached to a diaphragm wherein said base may be positioned within said cavity. The sensor may be a capacitive pressure sensor. The diaphragm may be connected to the housing to hermetically seal said housing. The sensor may include electrical contacts positioned on the diaphragm. The attachment between the base and the diaphragm may define a capacitive gap and at least one discontinuity configured to enhance at least one performance parameter of said implant.

Abstract: Described herein is a system including a catheter, an optical circuit, a pulsed field ablation energy source, and a processing device. The catheter includes a proximal section, a distal section, and a shaft coupled between the proximal section and the distal section. The optical circuit is configured to transport light at least partially from the proximal section to the distal section and back. The pulsed field ablation energy source is coupled to the catheter and configured to transmit pulsed electrical signals to a tissue sample. The processing device is configured to analyze one or more optical signals received from the optical circuit to determine changes in polarization or phase retardation of light reflected or scattered by the tissue sample, and determine changes in a birefringence of the tissue sample based on the changes in polarization or phase retardation.

Abstract: Described herein is a system including a catheter, an optical circuit, a pulsed field ablation energy source, and a processing device. The catheter includes a proximal section, a distal section, and a shaft coupled between the proximal section and the distal section. The optical circuit is configured to transport light at least partially from the proximal section to the distal section and back. The pulsed field ablation energy source is coupled to the catheter and configured to transmit pulsed electrical signals to a tissue sample. The processing device is configured to analyze one or more optical signals received from the optical circuit to determine changes in polarization or phase retardation of light reflected or scattered by the tissue sample, and determine changes in a birefringence of the tissue sample based on the changes in polarization or phase retardation.

Abstract: The present disclosure relates to various anchoring systems for a catheter delivered device. In one instance the anchoring systems of the present disclosure are designed to be used in connection with a pulmonary artery implant device. In one embodiment, an anchoring system of the present disclosure comprises two anchoring ends, a distal end anchoring structure and a proximal end anchoring structure, where at least one of the distal or proximal anchoring structures has a clover-shaped structure formed by at least three lobes. In another embodiment, the distal anchoring structure includes an elongated and angled shape formed by wire material. In another embodiment, both the distal and proximal anchoring structures have a clover-shaped structure formed by at least three lobes.

Abstract: Described herein is a system including a catheter, an optical circuit, a pulsed field ablation energy source, and a processing device. The catheter includes a proximal section, a distal section, and a shaft coupled between the proximal section and the distal section. The optical circuit is configured to transport light at least partially from the proximal section to the distal section and back. The pulsed field ablation energy source is coupled to the catheter and configured to transmit pulsed electrical signals to a tissue sample. The processing device is configured to analyze one or more optical signals received from the optical circuit to determine changes in polarization or phase retardation of light reflected or scattered by the tissue sample, and determine changes in a birefringence of the tissue sample based on the changes in polarization or phase retardation.

Abstract: The present disclosure relates to various anchoring systems for a catheter delivered device. In one instance the anchoring systems of the present disclosure are designed to be used in connection with a pulmonary artery implant device. In one embodiment, an anchoring system of the present disclosure comprises two anchoring ends, a distal end anchoring structure and a proximal end anchoring structure, where at least one of the distal or proximal anchoring structures has a clover-shaped structure formed by at least three lobes. In another embodiment, the distal anchoring structure includes an elongated and angled shape formed by wire material. In another embodiment, both the distal and proximal anchoring structures have a clover-shaped structure formed by at least three lobes.

Abstract: The present disclosure relates to various anchoring assemblies, systems, and methods for a catheter delivered device or otherwise implantable biomedical sensors. In one instance the anchoring systems of the present disclosure are designed to be used in connection with a biomedical sensor configured to be placed in the various locations within the anatomy of a patient including: a junction of a renal vein and an inferior vena cava, a junction of a jugular vein branch and a subclavian vein branch, a junction of a brachiocephalic vein branch and a superior vena cava, or a junction of an iliac vein branch and an inferior vena cava. In one embodiment, an biomedical sensor and anchoring system can be implanted in an organ of a patient or in an organ to be transplanted within a patient.

Abstract: Disclosed is an implant and method of making an implant. The implant having a housing that defines a cavity. The housing includes a sensor comprising a base attached to a diaphragm wherein said base may be positioned within said cavity. The sensor may be a capacitive pressure sensor. The diaphragm may be connected to the housing to hermetically seal said housing. The sensor may include electrical contacts positioned on the diaphragm. The base may define a capacitive gap and a vent wherein the electrodes may be positioned within said capacitive gap such that at least a portion of the electrical contacts extend through the vent. The implant may include a coil in electric communication with the sensor, said coil may be positioned within said housing. A printed circuit board having at least one component may be attached to the floating base.

Abstract: Provided are various embodiments of improvements made to methods, systems and assemblies of implant delivery systems and the associated implants. In one embodiment, provided is an implant delivery system comprising an implant, a first sheath and a second sheath each extending from a proximal end of said implant delivery system, the first sheath is translatable relative to said second sheath wherein said implant is connected to an exterior surface of said first sheath, and wherein said first sheath and said second sheath are movable with respect to one another to deploy said implant to a target site in an anatomy. Said delivery system may be configured to be partially inserted into a blood vessel of a human body such that said proximal end remains external to said body and said distal end is internal to said body.

Abstract: Disclosed is an implant and method of making an implant. The implant having a housing that defines a cavity. The housing includes a sensor comprising a base attached to a diaphragm wherein said base may be positioned within said cavity. The sensor may be a capacitive pressure sensor. The diaphragm may be connected to the housing to hermetically seal said housing. The sensor may include electrical contacts positioned on the diaphragm. The base may define a capacitive gap and a vent wherein the electrodes may be positioned within said capacitive gap such that at least a portion of the electrical contacts extend through the vent. The implant may include a coil in electric communication with the sensor, said coil may be positioned within said housing. A printed circuit board having at least one component may be attached to the floating base.

Abstract: Disclosed is an implant and method of making an implant. The implant having a housing that defines a cavity. The housing includes a sensor comprising a base attached to a diaphragm wherein said base may be positioned within said cavity. The sensor may be a capacitive pressure sensor. The diaphragm may be connected to the housing to hermetically seal said housing. The sensor may include electrical contacts positioned on the diaphragm. The attachment between the base and the diaphragm may define a capacitive gap and at least one discontinuity configured to enhance at least one performance parameter of said implant.