Abstract: An optical coherence tomography imaging system includes a Fourier domain optical coherence tomography sensor system, a signal processing system configured to communicate with the Fourier domain optical coherence tomography sensor system to receive detection signals therefrom and to provide imaging signals, and an image display system configured to communicate with the signal processing system to receive the imaging signals. The signal processing system includes a parallel processor configured to calculate structure information and Doppler information from the detection signals in real time such that the imaging signals provide a real time display of combined structure and flow of an object under observation.

Abstract: A motion-compensated optical coherence tomography system includes an optical coherence tomography sensor that includes a common-path optical fiber having an end for emitting light, reflecting reference light and receiving returned light for detection; a motion-compensation system attached to the common-path optical fiber and operable to move at least a portion of the optical fiber so as to compensate for motion between the end of the common-path optical fiber and an object being imaged; and a feedback control system configured to communicate with the optical coherence tomography sensor and the motion-compensation system. The feedback control system is configured to receive information concerning a measured distance of the end of the common-path optical fiber from the object and provide instructions to the motion-compensation system to decrease an amount of deviation of the measured distance from a desired distance.

Abstract: A real-time, dispersion-compensated low coherence interferometric system includes a fiber-optic, a bulk-optic, or a combination of bulk and fiber-optic system comprising a reference path and an observation path; a light source optically coupled to the fiber-optic, bulk-optic, or combination of bulk and fiber-optic system to illuminate the reference and observation paths; an optical detection system arranged to receive combined light returned along the reference and observation paths, the optical detection system providing detection signals; and a data processing system arranged to communicate with the optical detection system to receive the detection signals. The data processing system includes a parallel processor configured to process the detection signals to provide real-time dispersion compensation to numerically compensate for dispersion in the reference path relative to the observation path.

Abstract: A motion-compensated confocal microscope includes a laser scanning system, a fiber-optic component having a proximal end and a distal end such that the fiber-optic component is optically coupled to the laser scanning system to receive illumination light at the proximal end and to emit at least a portion of the illumination light at the distal end, and a detection system configured to receive and detect light returned from a specimen being observed and to output an image signal. The light returned from the specimen is received by the distal end of the fiber-optic component and transmitted back and out the proximal end of the fiber-optic component.

Abstract: A method, system and computer program product for managing and querying a graph. The method includes the steps of: receiving a graph; partitioning the graph into homogeneous blocks; compressing the homogeneous blocks; and storing the compressed homogeneous blocks in files where at least one of the steps is carried out using a computer device.

Abstract: A surgical tool system according to an embodiment of the current invention includes a surgical tool, and an interferometry system optically coupled to the surgical tool. The surgical tool includes a body section, a sensor section at least one of attached to or integral with the body section, and a surgical section at least one of attached to or integral with the sensor section at an opposing end of the sensor section from the body section. The sensor section comprises an interferometric optical sensor defining a reference distance that changes in response to at least one of a force or a torque when applied to the surgical section of the surgical tool.

Abstract: A method, system and computer program product for managing and querying a graph. The method includes the steps of: receiving a graph; partitioning the graph into homogeneous blocks; compressing the homogeneous blocks; and storing the compressed homogeneous blocks in files where at least one of the steps is carried out using a computer device.

Abstract: An optical coherence tomography system having real-time artifact and saturation correction includes an optical coherence tomography unit, and a signal processing and display system adapted to communicate with the optical coherence tomography unit to receive imaging signals therefrom. The optical coherence tomography system is a Fourier Domain optical coherence tomography system. The signal processing and display system includes a parallel processor configured to correct the imaging signals, in real time, to at least partially remove image artifacts and saturation based on a subset of image data within an image frame.

Abstract: An illumination system includes a light source, an optical waveguide that has a proximal end and a distal end such that the proximal end is arranged to receive light from the light source and the distal end is suitable to illuminate an object of interest; and an optical coupler constructed and arranged to couple light from the light source into the optical waveguide. The optical coupler includes a reflective surface that reflects at least some light diverging from the light source to be coupled into the optical waveguide.

Abstract: A four-dimensional optical coherence tomography imagining and guidance system includes an optical coherence tomography system, a data processing system adapted to communicate with the optical coherence tomography system, and a display system adapted to communicate with the data processing system. The optical coherence tomography system is configured to provide data corresponding to a plurality of volume frames per second. The data processing system is configured to receive and process the data and provide three-dimensional image data to the display system such that the display system displays a rendered real-time three-dimensional image.

Abstract: A dark field endoscopic microscope includes an illumination system, an objective lens unit arranged in an optical path of the illumination system, an optical fiber bundle optically coupled to the objective lens unit, and an observation system arranged in an optical return path from the optical fiber bundle. The illumination system provides oblique off-axial illumination while axial rays are at least attenuated.

Abstract: A mid-infrared laser therapy tool includes a handle, a mid-infrared laser contained within the handle, and a light pipe optically coupled to the mid-infrared laser. The mid-infrared laser emits at a wavelength within a wavelength band from about 6.0 ?m to about 6.5 ?m. A mid-infrared laser therapy system includes a mid-infrared laser therapy tool, an optical coherence tomography system adapted to communicate with the mid-infrared laser therapy tool, and a motorized-platform control system adapted to communicate with the mid-infrared laser therapy tool and the optical coherence tomography system. The mid-infrared laser therapy tool comprises a mid-infrared laser emits at a wavelength within a wavelength band from about 6.0 ?m to about 6.5 ?m.

Abstract: Computer-implemented methods, systems, and articles of manufacture for determining the importance of a data item. A method includes: (a) receiving a node graph; (b) approximating a number of neighbor nodes of a node; and (c) calculating a average shortest path length of the node to the remaining nodes using the approximation step, where this calculation demonstrates the importance of a data item represented by the node. Another method includes: (a) receiving a node graph; (b) building a decomposed line graph of the node graph; (c) calculating stationary probabilities of incident edges of a node graph node in the decomposed line graph, and (d) calculating a summation of the stationary probabilities of the incident edges associated with the node, where the summation demonstrates the importance of a data item represented by the node. Both methods have at least one step carried out using a computer device.

Abstract: A sensing system for implant surgery includes an insertion device for moving an implant into a narrow cavity in a patient's body. A sensor measures the distance from an end of the insertion device to anatomic surfaces at a distance from the end of the insertion device. An optical coherence tomography (OCT) system integrates the sensor and produces OCT images, which can be quantified to distance measurements. The system is particularly useful for cochlear implant surgery.

Abstract: A surgical instrument has a surgical tool that has a proximal end and a distal end, and an optical sensor that has at least a portion attached to the surgical tool. The surgical tool has a portion that is suitable to provide a reference portion of the surgical tool, and the optical sensor has an end fixed relative to the reference portion of the surgical tool such that the reference portion of the surgical tool can be detected along with tissue that is proximate or in contact with the distal end of the surgical tool while in use.

Abstract: A tunable highly efficient and high power ultraviolet (UV) laser source with good spatial beam quality is disclosed. A plurality of laser lights are generated by ytterbium (Yb) doped fiber laser and erbium/ytterbium (Er/Yb) doped fiber laser. In order to achieve a desired UV wavelength, the Yb-doped and Er/Yb-doped fiber lasers are tuned to generate laser lights of certain wavelengths based on a desired UV light wavelength. The laser lights from the Er/Yb-doped fiber laser and the Yb-doped fiber laser are frequency-doubled. The frequency-doubled laser lights are non-linearly frequency-mixed to generate a UV light with the desired wavelength.

Abstract: Single event upset failure are suppressed in GaAs-based electronics by implanting the GaAs substrate with an appropriate dose of O and at least one of either Al, Cr, or In.

Abstract: In accordance with one aspect of the invention, a ring laser configuration having a polarizer, and whose cavity loop has substantially no net dispersion, permitting mode locked pulsing of high intensity and large bandwidth. In accordance with another aspect of the invention, a system using this laser to interrogate a plurality of arrays of Bragg gratings by use of both time and wavelength division multiplexing, increasing the total number of interrogatable gratings. In accordance with a third aspect of the invention, a system for interrogating one or more fiber Bragg gratings separated from the optical source by a dispersive optical fiber. As such a grating distends responsive to some measurand, its reflection frequency changes, and the traversal time of the reflection over the dispersive fiber changes, permitting inference of the measurand.