Abstract: Described is a voltage regulator with adaptive gain, which comprises: a plurality of power-gate transistors controllable by a digital bus, the plurality of power-gate transistors operable to provide a first power supply to a load, and to receive a second power supply as input; an analog-to-digital converter (ADC) to receive the first power supply and to generate a digital output representative of the first power supply; and a controller to receive the digital output representative of the first power supply and to generate the digital bus for controlling the plurality of power-gate transistors such that a transfer function of the plurality of power-gate transistors is substantially linear over an operating range.

Abstract: A method includes capturing a first set of optical images of the subject while a subject is lying on a table of a Magnetic Resonance (MR) scanner. This first set of optical images is acquired without any MR phased-array coils placed on the subject. While the subject continues to lie on the table of the MR scanner, a second set of optical images of the subject is acquired with the MR phased-array coils placed on the subject. Aside from the optical images, a set of MR images of the subject is acquired using the MR scanner. The first and second set of optical images are registered to the MR images. Following registration, the first and second set of optical images are used to determine element positioning of the MR phased-array coils in the set of MR images.

Abstract: A method includes capturing a first set of optical images of the subject while a subject is lying on a table of a Magnetic Resonance (MR) scanner. This first set of optical images is acquired without any MR phased-array coils placed on the subject. While the subject continues to lie on the table of the MR scanner, a second set of optical images of the subject is acquired with the MR phased-array coils placed on the subject. Aside from the optical images, a set of MR images of the subject is acquired using the MR scanner. The first and second set of optical images are registered to the MR images. Following registration, the first and second set of optical images are used to determine element positioning of the MR phased-array coils in the set of MR images.

Abstract: Examples of load balancing across multiple computing nodes of distributed computing systems is described herein. Examples include determining whether an application request is part of a first application request set or a second application request set, and routing the application request to a first computing node or a second computing node of a computing node cluster based on the determination. Other examples include determining whether a database operation request directed to a database is part of a first database operation set or a second database operation set, and routing the database operation request to a first server using a first instance of the database or a second server using a second instance of the database based on the determination. Routing the application and database operation requests based on criteria of the respective request may improve execution efficiency of the requests.

Abstract: The present invention provides a preservative free ophthalmic formulation. In particular, the ophthalmic formulations of the invention are aqueous formulations comprising nanoemulsion of oil. The present invention also provides a method for treating an eye disorder. In one particular embodiment, the invention provides methods for treating dry eye syndrome using an preservative free formulation comprising a nanoemulsion of oil and alpha 2 adrenergic agonist, pharmaceutically acceptable salt thereof or a mixture thereof. In particular, the alpha 2 adrenergic agonist of the invention has a higher alpha 2A agonist activity compared to alpha 2B agonist activity. This invention also provides a preservative free ophthalmic composition comprising a nanoemulsion of oil, a therapeutically effective amount of an alpha 2 adrenergic agonist, a pharmaceutically acceptable salt thereof or a combination thereof as an active ingredient for treating a dry eye syndrome.

Abstract: An aspect of the present disclosure is directed to scheduling of a fixed number of non-sharable resources. In one embodiment, a schedule data specifying respective durations in which a non-sharable resource is allocated to corresponding sets of users is maintained. A check is performed in a duration (between start and end time instances) whether the non-sharable resource is being used by a set of users specified in the schedule data. The non-sharable resource is deallocated from the set of users within the duration if checking determines that the non-sharable resource is not being used by the set of users. Accordingly, the non-sharable resource is made available for allocation before the end time instance.

Abstract: Described is a voltage regulator with adaptive gain, which comprises: a plurality of power-gate transistors controllable by a digital bus, the plurality of power-gate transistors operable to provide a first power supply to a load, and to receive a second power supply as input; an analog-to-digital converter (ADC) to receive the first power supply and to generate a digital output representative of the first power supply; and a controller to receive the digital output representative of the first power supply and to generate the digital bus for controlling the plurality of power-gate transistors such that a transfer function of the plurality of power-gate transistors is substantially linear over an operating range.

Abstract: Described is an apparatus comprising: first and second processing cores; and a PCU which is operable to: generate a first VID for an off-die regulator external to the apparatus, the first VID resulting in a first power supply for the first processing core; and generate a second VID different from the first VID, the second VID resulting in a second power supply for the second processing core. Described is an apparatus comprising: a plurality of power-gate transistors controllable by a digital bus, the plurality of power-gate transistors operable to provide a first power supply to a processing core, and to receive a second power supply as input; an ADC to receive the first power supply and to generate a digital output representative of the first power supply; and a controller to receive the digital output representative and to generate the digital bus for controlling the plurality of power-gate transistors.

Abstract: Described is a voltage regulator with adaptive gain, which comprises: a plurality of power-gate transistors controllable by a digital bus, the plurality of power-gate transistors operable to provide a first power supply to a load, and to receive a second power supply as input; an analog-to-digital converter (ADC) to receive the first power supply and to generate a digital output representative of the first power supply; and a controller to receive the digital output representative of the first power supply and to generate the digital bus for controlling the plurality of power-gate transistors such that a transfer function of the plurality of power-gate transistors is substantially linear over an operating range.

Abstract: Described is an apparatus comprising: first and second processing cores; and a PCU which is operable to: generate a first VID for an off-die regulator external to the apparatus, the first VID resulting in a first power supply for the first processing core; and generate a second VID different from the first VID, the second VID resulting in a second power supply for the second processing core. Described is an apparatus comprising: a plurality of power-gate transistors controllable by a digital bus, the plurality of power-gate transistors operable to provide a first power supply to a processing core, and to receive a second power supply as input; an ADC to receive the first power supply and to generate a digital output representative of the first power supply; and a controller to receive the digital output representative and to generate the digital bus for controlling the plurality of power-gate transistors.

Abstract: The present invention provides a preservative free ophthalmic formulation. In particular, the ophthalmic formulations of the invention are aqueous formulations comprising nanoemulsion of oil. The present invention also provides a method for treating an eye disorder. In one particular embodiment, the invention provides methods for treating dry eye syndrome using an preservative free formulation comprising a nanoemulsion of oil and alpha 2 adrenergic agonist, pharmaceutically acceptable salt thereof or a mixture thereof. In particular, the alpha 2 adrenergic agonist of the invention has a higher alpha 2A agonist activity compared to alpha 2B agonist activity. This invention also provides a preservative free ophthalmic composition comprising a nanoemulsion of oil, a therapeutically effective amount of an alpha 2 adrenergic agonist, a pharmaceutically acceptable salt thereof or a combination thereof as an active ingredient for treating a dry eye syndrome.

Abstract: The present invention relates to a method for treating a dry eye syndrome using an alpha 2 adrenergic agonist, pharmaceutically acceptable salt thereof or a mixture thereof. In particular, the alpha 2 adrenergic agonist of the invention has a higher alpha 2A agonist activity compared to alpha 2B agonist activity. This invention also relates to an ophthalmic composition comprising a therapeutically effective amount of an alpha 2 adrenergic agonist, a pharmaceutically acceptable salt thereof or a combination thereof as an active ingredient for treating a dry eye syndrome.

Abstract: Described is an apparatus comprising: first and second processing cores; and a PCU which is operable to: generate a first VID for an off-die regulator external to the apparatus, the first VID resulting in a first power supply for the first processing core; and generate a second VID different from the first VID, the second VID resulting in a second power supply for the second processing core. Described is an apparatus comprising: a plurality of power-gate transistors controllable by a digital bus, the plurality of power-gate transistors operable to provide a first power supply to a processing core, and to receive a second power supply as input; an ADC to receive the first power supply and to generate a digital output representative of the first power supply; and a controller to receive the digital output representative and to generate the digital bus for controlling the plurality of power-gate transistors.

Abstract: Described is an apparatus comprising: first and second processing cores; and a PCU which is operable to: generate a first VID for an off-die regulator external to the apparatus, the first VID resulting in a first power supply for the first processing core; and generate a second VID different from the first VID, the second VID resulting in a second power supply for the second processing core. Described is an apparatus comprising: a plurality of power-gate transistors controllable by a digital bus, the plurality of power-gate transistors operable to provide a first power supply to a processing core, and to receive a second power supply as input; an ADC to receive the first power supply and to generate a digital output representative of the first power supply; and a controller to receive the digital output representative and to generate the digital bus for controlling the plurality of power-gate transistors.

Abstract: The present invention relates to a method for treating a dry eye syndrome using an alpha 2 adrenergic agonist, pharmaceutically acceptable salt thereof or a mixture thereof. In particular, the alpha 2 adrenergic agonist of the invention has a higher alpha 2A agonist activity compared to alpha 2B agonist activity. This invention also relates to an ophthalmic composition comprising a therapeutically effective amount of an alpha 2 adrenergic agonist, a pharmaceutically acceptable salt thereof or a combination thereof as an active ingredient for treating a dry eye syndrome.

Abstract: Methods and systems to regulate a voltage with multiple selectable voltage regulator (VR) modes, using multiple corresponding circuits and/or a configurable circuit. The circuit may be configurable for one or more of a power-gate VR mode, a switched-capacitor VR (SCVR) mode, and a linear mode, such as a low drop-out (LDO) VR mode. A feedback controller, such as a proportional-integral-derivative (PID) controller, may configure and/or control a multi-mode VR for a selected VR mode. The feedback controller may select a VR mode based on a reference voltage and voltage ranges associated with the VR modes. The circuit may be configurable as banks of VRs, and the controller may be implemented to transition between VR modes by switching sub-banks between modes until the transition is complete.

Abstract: The present invention discloses pharmaceutical preparations for treatment of eye disorders containing an alpha 2 adrenergic agonist, to processes for producing the pharmaceutical preparations and methods for treatment of various eye disorders including dry eye and Meibomian gland dysfunction and a medicinal applicator for topical application of an alpha 2 adrenergic agonist to a subject, a package assembly for the medicinal applicator and methods of using the medicinal applicator to treat eye disorders.

Abstract: Described is an apparatus comprising: first and second processing cores; and a PCU which is operable to: generate a first VID for an off-die regulator external to the apparatus, the first VID resulting in a first power supply for the first processing core; and generate a second VID different from the first VID, the second VID resulting in a second power supply for the second processing core. Described is an apparatus comprising: a plurality of power-gate transistors controllable by a digital bus, the plurality of power-gate transistors operable to provide a first power supply to a processing core, and to receive a second power supply as input; an ADC to receive the first power supply and to generate a digital output representative of the first power supply; and a controller to receive the digital output representative and to generate the digital bus for controlling the plurality of power-gate transistors.

Abstract: The present invention discloses pharmaceutical preparations for treatment of eye disorders containing an alpha 2 adrenergic agonist, to processes for producing the pharmaceutical preparations and methods for treatment of various eye disorders including dry eye and Meibomian gland dysfunction and a medicinal applicator for topical application of an alpha 2 adrenergic agonist to a subject, a package assembly for the medicinal applicator and methods of using the medicinal applicator to treat eye disorders.

Abstract: Described is a voltage regulator with adaptive gain, which comprises: a plurality of power-gate transistors controllable by a digital bus, the plurality of power-gate transistors operable to provide a first power supply to a load, and to receive a second power supply as input; an analog-to-digital converter (ADC) to receive the first power supply and to generate a digital output representative of the first power supply; and a controller to receive the digital output representative of the first power supply and to generate the digital bus for controlling the plurality of power-gate transistors such that a transfer function of the plurality of power-gate transistors is substantially linear over an operating range.