Abstract: A sealing element is suggested, in particular one for closing primary packaging for medications, that has at least two parts, which touch each other at least in some areas. This is characterized in that steam-permeable channels are provided for sterilization of the contact surfaces. In addition, a method is suggested for manufacturing a syringe system with a sealing element. This is characterized by the steps preliminary assembly of the sealing element, sterilization of the sealing element, final assembly of the sealing element.

Abstract: A sealing element is suggested, in particular one for closing primary packaging for medications, that has at least two parts, which touch each other at least in some areas. This is characterized in that steam-permeable channels are provided for sterilization of the contact surfaces. In addition, a method is suggested for manufacturing a syringe system with a sealing element. This is characterized by the steps—preliminary assembly of the sealing element, —sterilization of the sealing element, —final assembly of the sealing element.

Abstract: A prefilled medical syringe includes a syringe barrel. A syringe plunger is disposed in the barrel and displaceable by means of a plunger rod. An end plug closes off a cannula side of the syringe barrel. The plug is provided with a through-channel closed off by a membrane. A finger support is disposed at the end of the syringe barrel opposite the end plug and provided with a through-opening for the plunger rod. A thread system cooperates with the plunger rod and the finger support. The thread system includes a thread sleeve detachably connected with the finger support. The thread sleeve is provided with an inner thread that cooperates with an outer thread on the plunger rod.

Abstract: A hypodermic syringe has a hollow body adapted to hold a liquid, an inner cap fitted over an end of the body, and an axially extending needle seated in the inner cap and having an outer point projecting axially outward from the inner cap and an inner point projecting axially inward from the inner cap toward the body. An outer cap fittable over the inner cap and needle is connected to a clamp ring engageable around the inner cap by a frangible web. Interengaging formations on the ring and on the inner cap releasably retain the outer cap in an outer position spaced axially outward of the body and in which an interior of the outer cap is open to the exterior and an inner position spaced axially closely to the body and in which the interior of the outer cap is not open to the exterior.

Abstract: Prefilled syringes are made by displacing a succession of syringes along a conveyor path from a supply station successively through a marking station, a filling station, and to a downstream packing station. Each of the syringes is filled with a predetermined dose of a medicament in the filling station. The syringes are marked in the marking station with machine-readable data identifying the medicament to be put in the empty syringe at the filling station. The syringes are scanned downstream of the marking station and any syringe whose data is not readable is then removed from the conveyor path, as is any syringe whose data does not correspond to the medicament filled into the syringe at the filling station.

Abstract: A container which is to be autoclaved has a shiftable plunger that defines a compartment filled with a fluid. The container is confined in a pressurizable chamber and heated so as to change a pressure in the compartment of the container. The pressure in the compartment of the container is monitored and an output corresponding thereto is generated. Pressure in the chamber around the container is continuously varied so as to be generally equal to the instantaneous monitored pressure in the compartment of the container. In this manner the plunger is not moved by thermal expansion or contraction of the fluid.

Abstract: A syringe holding a solvent and a soluble component has a tubular body formed its front and rear ends with a bypass, a plunger axially slidable in the body, and a stem projecting axially rearward out of the body from the plunger. A cover fits over the front end of the body and is so tight that the front compartment can be pressurized to a superatmospheric pressure without leakage out the front end. A free piston slidable in the body forward of the plunger subdivides the body forward of the plunger into a front compartment at the front body end holding the soluble component and a rear compartment between the plunger and the piston and holding the solvent. Stops are provided for arresting the free piston when it is level with the bypass in a position permitting flow through the bypass between the compartments.

Abstract: Prefilled syringes are made by displacing a succession of syringes along a conveyor path from a supply station successively through a marking station, a filling station, and to a downstream packing station. Each of the syringes is filled with a predetermined dose of a medicament in the filling station. The syringes are marked in the marking station with machine-readable data identifying the medicament to be put in the empty syringe at the filling station. The syringes are scanned downstream of the marking station and any syringe whose data is not readable is then removed from the conveyor path, as is any syringe whose data does not correspond to the medicament filled into the syringe at the filling station.

Abstract: A sealing element is suggested, in particular one for closing primary packaging for medications, that has at least two parts, which touch each other at least in some areas.

Abstract: A container which is to be autoclaved has a shiftable plunger that defines a compartment filled with a fluid. The container is confined in a pressurizable chamber and heated so as to change a pressure in the compartment of the container. The pressure in the compartment of the container is monitored and an output corresponding thereto is generated. Pressure in the chamber around the container is continuously varied so as to be generally equal to the instantaneous monitored pressure in the compartment of the container. In this manner the plunger is not moved by thermal expansion or contraction of the fluid.

Abstract: An apparatus is proposed for manufacturing a syringe, which has a syringe body composed of glass and a hollow needle, for medical purposes, and is characterized by a laser beam generating device (3) having a laser generator (5) for producing a laser beam (9), a beam forming and/or guidance device (7), and by a holding device (17) for holding and positioning the syringe body (13).

Abstract: An apparatus for mounting a tip cap having a maximum diameter over a syringe subassembly having a syringe body with an end carrying a needle has a holder holding the subassembly with the needle substantially on an axis and a tubular guide having a feed passage generally centered on the axis adjacent the holder, of an inside diameter greater than the maximum tip-cap diameter, and open toward the holder. A stop can move between a blocking position between the guide and the holder and an unblocking position offset therefrom. The tip cap is fed through the passage to a position arrested on the stop in the blocking position thereof. A nozzle opening into the passage injects pressurized gas into the passage and thereby spins the tip cap in the passage about the axis. The stop can then be moved from the blocking into the unblocking position for displacing the spinning tip cap from the guide onto the syringe subassembly in the holder. The nozzle opens tangentially into the passage.

Abstract: A syringe holding a solvent and a soluble component has a tubular body formed its front and rear ends with a bypass, a plunger axially slidable in the body, and a stem projecting axially rearward out of the body from the plunger. A cover fits over the front end of the body and is so tight that the front compartment can be pressurized to a superatmospheric pressure without leakage out the front end. A free piston slidable in the body forward of the plunger subdivides the body forward of the plunger into a front compartment at the front body end holding the soluble component and a rear compartment between the plunger and the piston and holding the solvent. Stops are provided for arresting the free piston when it is level with the bypass in a position permitting flow through the bypass between the compartments.

Abstract: A syringe assembly has a syringe body adapted to be filled with an injectable liquid and having an annular neck defining an axis and having an axially outwardly open outlet. The neck is adapted to carry a needle. An elastomeric plug engaged axially inward with the neck closes the outlet and a holding ring is fixed to the neck below the plug. A retaining sleeve around the neck is fixed to the holding ring and a cup-shaped safety cap is fixed to the plug and has an end edge confronting the retaining sleeve and spaced axially therefrom. Frangible formations extend from the cap edge to the sleeve.

Abstract: An inside wall of an elongated syringe body is coated by supplying at least an outer surface of an applicator ring with a coating of silicon oil while displacing a rod carrying the coated ring from a rear end to a front end of the body with the ring in continuous annular engagement with the inside wall thereof so as to transfer the oil from the ring to the inside wall. Thereafter a scraper ring also carried on the rod is displaced from the front end to the rear end of the body with the scraper ring in continuous annular engagement with the inside wall so as to scrape excess silicone oil from the inside wall.

Abstract: A medical syringe has a tubular body extending along an axis and having a front end and a rear end, a plunger axially slidable in the body and carrying a stem projecting axially rearward out of the body from the plunger, and a free piston slidable in the body forward of the plunger and subdividing the body forward of the plunger into a front compartment at the front body end and a rear compartment between the plunger and the piston. The body is formed with a bypass passage forward of the piston in a starting position so the front compartment can hold a soluble medicament and the rear compartment can hold its solvent. Structure at the rear body end forms a radially inwardly open angularly limited cutout and at least two axially spaced, angularly offset, and radially outwardly projecting stop bumps on the stem are axially displaceable through the cutout in respective angularly offset positions of the stem.

Abstract: A syringe has a protective sleeve with finger seats effective in both axial directions and the thumb rest of the plunger is also effective in both axial locations, so that, after injection, the fingers and thumb are spread apart to advance the protective sleeve over the needle.

Abstract: A syringe assembly has a tubular syringe body centered on and extending along an axis and formed at a rear end with a radially outwardly projecting rim. A finger brace of limitedly elastically deformable material is formed with an end plate bearing axially forward on the rear end and formed with a central hole. A tube projects axially forward from the hole of the plate into the body at the rear syringe end, and a collar extends axially forward form the plate outside the tube and is formed with a plurality of angularly spaced and radially inwardly projecting teeth engaged under the rim. The plate is also formed adjacent each of the teeth with an axially throughgoing and angularly elongated slot defining a radially elastically deflectable side portion carrying the respective tooth.

Abstract: A syringe subassembly comprised of a tubular syringe body having a front end provided with a forwardly projecting needle and fitted over the needle with a cap of a dielectric material is tested by juxtaposing an outer electrode with the cap, juxtaposing an inner electrode with the needle, applying a high electrical voltage across the electrodes, monitoring current flow between the electrodes, and rejecting the syringe subassembly if the monitored current flow exceeds a predetermined level. The cap is normally made of a plastic and has a higher dielectric constant than the gas surrounding the subassembly in the test station, normally air.

Abstract: An object, e.g. a piston or a fluid medicament, is inserted into a tubular syringe body centered on a syringe axis and having a pair of ends by an apparatus having a support movable axially forward toward and axially rearward away from the body and a tube extending along a sleeve axis generally parallel to the syringe axis, having a rear end fixed in the support and a front end fittable inside the syringe. A centering sleeve is formed centered on the sleeve axis with a generally frustoconical centering surface engageable with the rear body end surrounding the tube. This sleeve is displaceable axially on the support between a front position with the centering surface projecting axially forward past the tube front end and a rear position with the tube front end projecting axially forward past the centering surface. The support is displaced axially forward toward the body and thereby engages the centering surface coaxially with the body rear end.