Abstract: The present invention relates to trivalent, bispecific antibodies, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.

Abstract: A system may include a targeting cannula. The targeting cannula may extend from a first end to a second end and may define a hole that extends through the targeting cannula from the first end to the second end. The targeting cannula may include at least one visual marker disposed along a length of the targeting cannula. The at least one visual marker may be identifiable in an image obtained by a fluoroscope. The targeting cannula may include a coupling portion adjacent to the second end that may be configured to engage an imaging device. Methods of using the system also are disclosed.

Abstract: A technique of providing user guidance for surgical navigation is provided. A method implementation of the technique includes obtaining a predetermined spatial relationship between an optical tracking pattern and a through-hole extending through an implant, obtaining image data of the optical tracking pattern acquired by an imaging unit attached to a surgical instrument, obtaining a spatial relationship between the surgical instrument and the imaging unit at a point in time when the image data have been acquired, determining a spatial relationship between the surgical instrument and the through-hole, obtaining a plurality of predefined spatial relationships between the surgical instrument and the through-hole, and triggering simultaneous display of an indication of the plurality of predefined spatial relationships and an indication of the spatial relationship between the surgical instrument and the through-hole.

Abstract: A technique of providing user guidance for surgical navigation is provided. A method implementation of the technique includes obtaining a predetermined spatial relationship between an optical tracking pattern and a through-hole extending through an implant, obtaining image data of the optical tracking pattern acquired by an imaging unit attached to a surgical instrument, obtaining a spatial relationship between the surgical instrument and the imaging unit at a point in time when the image data have been acquired, determining a spatial relationship between the surgical instrument and the through-hole, obtaining a plurality of predefined spatial relationships between the surgical instrument and the through-hole, and triggering simultaneous display of an indication of the plurality of predefined spatial relationships and an indication of the spatial relationship between the surgical instrument and the through-hole.

Abstract: A technique of providing user guidance for surgical navigation is provided. A method implementation of the technique includes obtaining a predetermined spatial relationship between an optical tracking pattern and a through-hole extending through an implant, obtaining image data of the optical tracking pattern acquired by an imaging unit attached to a surgical instrument, obtaining a spatial relationship between the surgical instrument and the imaging unit at a point in time when the image data have been acquired, determining a spatial relationship between the surgical instrument and the through-hole, obtaining a plurality of predefined spatial relationships between the surgical instrument and the through-hole, and triggering simultaneous display of an indication of the plurality of predefined spatial relationships and an indication of the spatial relationship between the surgical instrument and the through-hole.

Abstract: A method for guiding bone removal during a surgical procedure includes receiving a two-dimensional image of at least a portion of a joint during the surgical procedure, determining an alignment of a pre-generated three-dimensional model of the at least a portion of the joint with the two-dimensional image based on one or more features in the two-dimensional image that are associated with the at least a portion of the joint, wherein the pre-generated three-dimensional model comprises a representation of planned bone removal, generating an overlay image based on the determined alignment, the overlay image comprising an overlay of at least a portion of the representation of planned bone removal on the two-dimensional image, and displaying the overlay image to guide bone removal during the surgical procedure.

Abstract: An improved process for the hydration of C2-C5 olefins to the corresponding alcohols via heterogeneous reactive extraction with ion exchange resin catalysts is provided. The improvements are based on the application of a structured catalytic packing, a simultaneous product extraction in multiple condensed phases for enhancement of the overall alcohol production rate and a simplified product purification procedure.

Abstract: An improved process for the hydration of C2-C5 olefins to the corresponding alcohols via heterogeneous reactive extraction with ion exchange resin catalysts is provided. The improvements are based on the application of a structured catalytic packing, a simultaneous product extraction in multiple condensed phases for enhancement of the overall alcohol production rate and a simplified product purification procedure.

Abstract: Disclosed are porous polymer/carrier solid phase reactants which consist of a polymer that consists of fine particles and is situated in the pore space of porous carrier materials. Reactive groups are bound to the polymer. Said groups act as reactants in organic-chemical syntheses. Said solid phase reactants can be produced as bulk material or tubes, plates or rods, can be built in pressure sealed housings and can be used in flow-through apparatuses or microtitration fields for the synthesis of organic products. Potential active agents can be produced at high speed by using the inventive porous polymer/carrier solid phase reactants that can be flown through convectively, whereby production requires only little isolation and cleaning.

Abstract: Disclosed are porous polymer/carrier solid phase reactants which consist of a polymer that consists of fine particles and is situated in the pore space of porous carrier materials. Reactive groups are bound to the polymer. Said groups act as reactants in organic-chemical syntheses. Said solid phase reactants can be produced as bulk material or tubes, plates or rods, can be built in pressure sealed housings and can be used in flow-through apparatuses or microtitration fields for the synthesis of organic products. Potential active agents can be produced at high speed by using the inventive porous polymer/carrier solid phase reactants that can be flown through convectively, whereby production requires only little isolation and cleaning.

Abstract: A process carried out in a reaction column for the chemical reaction of substances the reaction of which is affected by an unfavorable equilibrium position of the main reaction or a preceding equilibrium, wherein during the reaction one or more substances to be separated are continuously removed from the reaction mixture by one or more auxiliaries.

Abstract: The invention concerns a supported catalyst in the form of packing and constructed on an open-pore support material on whose external and internal surfaces a macro-porous ion exchange resin is mechanically and/or chemically affixed.

Abstract: An impact support for reinforcing a door of a motor vehicle, including a hollow profile part that is fastenable in the vehicle door. The hollow profile part having, at least in a central region thereof, a portion with a roughly oval cross section having a cross-sectional height that is greater than a cross-sectional depth. The hollow profile part is arranged in the motor vehicle door so that the depth lies parallel to an impact direction. The roughly oval cross section is formed by two straight sides which lie parallel at a distance from one another and are connected at their ends by a convex portion that has a radius that is always greater than half the distance between the two straight sides.

Abstract: An air hardening steel which is killed during casting used as material for manufacturing structural tubes for structural elements which are subjected to high mechanical loads, particularly for door reinforcements in the manufacture of automobiles. The steel is composed of in percent by weight:0.15-0.30% C0.50-0.80% Si2.05-3.35% Mnmax. 0.03% Pmax. 0.03% S0.50-1.00% Crmax. 0.60% Momax. 0.05% Al0.01-0.05% Ti0.0015-0.0035% B0.002-0.015% Nremainder iron and impurities,wherein:Ti(%):N(%).gtoreq.3.4%Mn(%)+Cr (%)+Mo(%)+Si(%).gtoreq.3.3%.

Abstract: Molded bodies in the form of packing bodies comprising a macroporous strongly acid or basic ion exchange resin having a voids fraction of 5-95 vol % of the macro shape without pores, a BET surface area of 0.1-1,000 sq m/g, and an ion exchange capacity of 0.05-10 meq/g.

Abstract: A reinforcement element, for the body of an automobile, consists of an elongated tensile elastic part comprising a cable, which is arranged in a hollow section attached to the body of the automobile. The cable extends through the hollow section and is attached by its ends independently of the hollow section to an attachment point on a part of the body. An impact against the body part causes the hollow section to contact and rest against the cable, such that the cable impedes further displacement of the hollow section with respect to the body. The cable may be a compound cable, each element having different routing, lengths, thicknesses, and/or construction. The mounting includes a tensioning element to prestress the cable, and may include a passive or active damping element.

Abstract: A method of evening a sliver produced by a carding machine in which a predetermined output rate and draft are set.

Abstract: A method of, and apparatus for, repairing mechanical and/or chemical damage to the surface of glass bottles destined for re-use. A bottle to be repaired is brought to a temperature in the region of the transformation point of the glass of the bottle, its surface is thermally treated with laser beams, and during the treatment the bottle surface is linearly scanned with the laser beams while rotating the bottle about its longitudinal axis to repair the surface. The apparatus comprises a laser source and optical means for directing the laser beam generated by the laser source onto the surface of a bottle being treated.

Abstract: The present invention relates to an arrangement for the discrete-time adaptive on-off switching control of a continuous-time process with a binary switching actuator, which uses for the determination of the on-off actuating signal a prediction of a process output sequence over several future sampling intervals as reaction to a possible process input sequence that is applied to a discrete-time linear process model and which estimates and updates in every sampling interval the parameters of the process model by means of a parameter estimation device in order to adapt them to the process to be controlled, even when the process behavior changes, and which has a device for the input and change of the setpoint, the limits of the process output and the sampling time as well as a measuring device for the periodical measurement of the process input.

Abstract: A process for producing ceramic, ceramic-metal or metal catalyst supports or catalysts with open, interconnecting pores. The process forming a dense agglomeration of spherical, cylindrical or similar bodies of generally uniform size. These bodies are connected together at their mutual contact points, thereby producing a framework corresponding generally to the macropores and pore interconnections of the finished material in terms of size and arrangement. The framework is then filled with a suspension containing as solid components the catalyst support material and/or the catalyst material. The suspension can also contain a binding agent. The framework is subsequently dissolved away after at least the partial hardening of the cast mass without destroying the structure produced during hardening.