Abstract: The invention relates to polymorphic forms of the calcium salt of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester. The calcium salt of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester is useful in the treatment of various conditions and disorders responsive to the inhibition of neutral endopeptidases.

Abstract: A method is disclosed for determining mechanical robustness of an overhead stowage bin for an aircraft includes repeatedly effecting an impact of a test body against an impact surface of the overhead stowage bin with a predefined impact force by a robotic arm of a manipulator, and investigating damage parameters of the overhead stowage bin.

Abstract: The present invention relates to the field of pharmacy, particularly to a pharmaceutical composition for oral administration comprising an (a) inert substrate and a (b) mixture comprising a non-bile acid farnesoid X receptor (FXR) agonist, such as 2-[(1R,3r,5S)-3-({5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl}methoxy)-8-azabicyclo[3.2.1]octan-8-yl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid, or a pharmaceutically acceptable salt thereof, and at least one binder. The present invention also relates to a process for preparing said pharmaceutical composition for oral administration; and to the use of said pharmaceutical composition in the manufacture of a medicament.

Abstract: The present invention relates to the field of pharmacy, particularly to a pharmaceutical composition for oral administration comprising an (a) inert substrate and a (b) mixture comprising a non-bile acid farnesoid X receptor (FXR) agonist, such as 2-[(1R,3r,5S)-3-({5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl}methoxy)-8-azabicyclo[3.2.1]octan-8-yl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid, or a pharmaceutically acceptable salt thereof, and at least one binder. The present invention also relates to a process for preparing said pharmaceutical composition for oral administration; and to the use of said pharmaceutical composition in the manufacture of a medicament.

Abstract: The The present invention relates to the field of pharmacy, particularly to a pharmaceutical composition for oral administration comprising an (a) inert substrate and a (b) mixture comprising a non-bile acid farnesoid X receptor (FXR) agonist, such as 2-[(1R,3r,5S)-3-({5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl}methoxy)-8-azabicyclo[3.2.1]octan-8-yl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid, or a pharmaceutically acceptable salt thereof, and at least one binder. The present invention also relates to a process for preparing said pharmaceutical composition for oral administration; and to the use of said pharmaceutical composition in the manufacture of a medicament.

Abstract: A method is disclosed for determining mechanical robustness of an overhead stowage bin for an aircraft includes repeatedly effecting an impact of a test body against an impact surface of the overhead stowage bin with a predefined impact force by a robotic arm of a manipulator, and investigating damage parameters of the overhead stowage bin.

Abstract: The invention relates to novel solvent-free, monomer-depleted polyisocyanate mixtures, and to the use thereof for producing light-resistant and weather-resistant polyurethane bodies with high optical refraction and low optical dispersion.

Abstract: A separator for the centrifugal separation of a flowable product into various phases or for the centrifugal clarification of a product includes a rotatable drum having a drum lower section and a drum upper section, a product clarifying arrangement arranged in the drum for clarifying a product to be treated in the centrifugal field. One or more, of all of the following elements are made from plastic or a plastic composite, the drum lower section, the drum upper section, the clarifying arrangement.

Abstract: The present invention relates to a novel crystalline anhydrous form of [(5-chlorothiophene-2-ylsulfonylcarbamoyl)-(4-(6-fluoro-7-(methylamino)-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)phenyl)amide, potassium salt, and its use in the treatment or prevention of a condition or a disorder with platelet ADP receptor inhibition, in particular, P2Y12 inhibition, in animals, particularly humans. It also relates processes for making such a novel crystalline form. The present invention also relates to a solid, oral formulation of this novel crystalline form, its preparation and use thereof.

Abstract: The present invention relates to a new manufacture process for producing an iron containing phosphate adsorbent, in particular to a process for manufacturing and isolating an iron(III)-based phosphate adsorbent which exhibits valuable pharmacological properties.

Abstract: The present invention relates to a novel crystalline anhydrous form of [(5-chlorothiophene-2-ylsulfonylcarbamoyl)-(4-(6-fluoro-7-(methylamino)-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)phenyl)amide, potassium salt, and its use in the treatment or prevention of a condition or a disorder with platelet ADP receptor inhibition, in particular, P2Y12 inhibition, in animals, particularly humans. It also relates processes for making such a novel crystalline form. The present invention also relates to a solid, oral for mulation of this novel crystalline form, its preparation and use thereof.

Abstract: The invention relates to a device for reducing latch loads during the process of loading and flying air cargo containers inside cargo holds of aircraft. The device exhibits a floor plate of a cargo unit of a transport means, an edge profile, a rail bumper as well as a first damping unit. The first damping unit is situated between the edge profile and the floor plate, or between the edge profile and the rail bumper of the cargo unit. The first damping unit is designed for damping a movement by the cargo unit in a direction of movement of the cargo unit so as to reduce the loads placed on the cargo unit.

Abstract: The invention relates to novel solvent-free, monomer-depleted polyisocyanate mixtures, and to the use thereof for producing light-resistant and weather-resistant polyurethane bodies with high optical refraction and low optical dispersion.

Abstract: The present invention relates to the use of solvent-free low-monomer polyisocyanates based on araliphatic diisocyanates for the production of light- and weather-resistant polyurethane bodies having a high light refraction and low dispersion.

Abstract: The present invention relates to a method of preparing N-substituted salicylamides or derivatives thereof, and their salts, hydrates and solvates. In particular, the present invention relates to a method of preparing N-(5-chlorosalicyloyl)-8-aminocaprylic acid (5-CNAC) and its corresponding disodium monohydrate.

Abstract: The invention relates to the use of solvent-free modified polyisocyanate mixtures on the basis of araliphatic diisocyanates for producing light- and weather-resistant polyurethane bodies having light refraction and low dispersion.

Abstract: Connecting the two band ends 10, 18 of a hose clamp is done by means of a guide hook 16 disposed on an inner band portion and engaging a guide hook receiving means 12 on the outer band end 10, and a support hook 17 also formed on the inner band portion and engaging a support hook receiving means 13 on the outer band portion. The support hook receiving means 13 is an embossment formed from the band material by cold deformation and being continuous with the band material on all sides, the inner surface of the support hook receiving means 13 having a support portion 25 adjacent to the outer band end 10 and extending at right angles with respect to the band surface. The support hook 17 has a nose 26 which faces away from the inner band end 18 and has a cut edge which nicks into the support portion 25 of the support hook receiving means 13 when the hose clamp is tightened.

Abstract: The present invention relates to a new iron containing phosphate adsorbent and its use e.g. for treating hyperphosphataemia.

Abstract: The present invention relates to a new iron containing phosphate adsorbent and its use e.g. for treating hyperphosphataemia.

Abstract: The invention relates to a device for reducing latch loads during the process of loading and flying air cargo containers inside cargo holds of aircraft. The device exhibits a floor plate of a cargo unit of a transport means, an edge profile, a rail bumper as well as a first damping unit. The first damping unit is situated between the edge profile and the floor plate, or between the edge profile and the rail bumper of the cargo unit. The first damping unit is designed for damping a movement by the cargo unit in a direction of movement of the cargo unit so as to reduce the loads placed on the cargo unit.