Abstract: The present disclosure relates to molecules with a solubility tag, wherein the solubility tag comprises a chito-oligosaccharide, and to methods for increasing the solubility of a molecule. Moreover, the present disclosure relates to antibody-drug conjugates with solubility tag, methods and compounds for preparing such antibody-drug conjugates, methods for increasing the solubility of antibody-drug conjugates, antibody-drug conjugates prepared by such methods, as well as the use of such antibody-drug conjugates in medical treatment.

Abstract: Method for the production of dry, free-flowing, stable hydrophobin preparations by spraying and drying aqueous hydrophobin solutions, if appropriate comprising additives in a spray device.

Abstract: The present invention is directed to a method utilizing a microorganism with reduced isocitrate dehydrogenase activity for the production of fine chemicals. Said fine chemicals may be amino acids, monomers for polymer synthesis, sugars, lipids, oils, fatty acids or vitamins and are preferably amino acids of the aspartate family, especially methionine or lysine, or derivatives of said amino acids, especially cadaverine. Furthermore, the present invention relates to a recombinant microorganism having a reduced isocitrate dehydrogenase activity in comparison to the initial microorganism and the use of such microorganisms in producing fine chemicals such as aspartate family amino acids and their derivatives.

Abstract: Method for the production of dry, free-flowing, stable hydrophobin preparations by spraying and drying aqueous hydrophobin solutions, if appropriate comprising additives in a spray device.

Abstract: A method for the disruption of biological cells by means of a homogenizer device which a) comprises an orifice plate having at least one inlet nozzle and an orifice plate having at least one exit nozzle, wherein, in the intermediate space between the orifice plates, a static mixer is situated and, if appropriate, mechanical energy is additionally introduced or b) comprises an orifice plate having at least one inlet nozzle and a baffle plate, wherein, in the intermediate space between the orifice plate and the baffle plate, if appropriate a static mixer is situated and/or mechanical energy is introduced.

Abstract: A device for butt welding pipes of thermoplastic plastic includes two pipe clamping units, aligned flush relative to each other, for clamping pipe ends therein. A first of the two units can be moved in the alignment direction by an electric motor and via mechanical drive elements. The reaction force corresponding to the infeed force is supported on the bottom via a support structure and a pipe end held in the second of the two units which is fixed in relation to the bottom. The mobile pipe end, held in the first pipe clamping unit, can be pressed against the fixed pipe end which is clamped in the second pipe clamping unit with a force measurable by a measurement device.