Patents by Inventor Uma Lakshmipathy
Uma Lakshmipathy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10983123Abstract: Provided herein are compositions, methods and uses that relate to or result from the identification of markers that can distinguish between cells at different stages of pluripotency. Certain embodiments provide markers that can distinguish between parental cells (i.e. differentiated cells), partially pluripotent (i.e. partially reprogrammed) and pluripotent (i.e. fully reprogrammed cells). Also provided here are uses of such differential markers, for example, in identification of cell potential, in diagnostics, in differential separation, and in creating efficient workflows that involve fewer steps and lesser time in identifying or separating a desired reprogrammed clone or cell line from a mixture of cells at various stages of pluripotency. In certain embodiments, the activity of these markers can be manipulated to influence cell potential for research or medical purposes.Type: GrantFiled: July 27, 2018Date of Patent: April 20, 2021Assignee: Life Technologies CorporationInventors: Uma Lakshmipathy, Rene Quintanilla, Joanna Asprer
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Patent number: 10583202Abstract: The invention relates to methods of altering gene expression by homologous recombination in a multipotent adult progenitor cell (MAPC). In particular, methods of producing a recombinant MAPC, of correcting a genetic defect in a mammal, of providing a functional and/or therapeutic protein to a mammal, and of transforming a MAPC are provided. MAPCs containing an erogenous DNA as well as recombinant MAPCs and their differentiated progeny are also provided.Type: GrantFiled: September 19, 2017Date of Patent: March 10, 2020Assignees: ABT Holding Company, Regents of the University of MinnesotaInventors: Catherine M. Verfaillie, Uma Lakshmipathy
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Publication number: 20190064164Abstract: Provided herein are compositions, methods and uses that relate to or result from the identification of markers that can distinguish between cells at different stages of pluripotency. Certain embodiments provide markers that can distinguish between parental cells (i.e. differentiated cells), partially pluripotent (i.e. partially reprogrammed) and pluripotent (i.e. fully reprogrammed cells). Also provided here are uses of such differential markers, for example, in identification of cell potential, in diagnostics, in differential separation, and in creating efficient workflows that involve fewer steps and lesser time in identifying or separating a desired reprogrammed clone or cell line from a mixture of cells at various stages of pluripotency. In certain embodiments, the activity of these markers can be manipulated to influence cell potential for research or medical purposes.Type: ApplicationFiled: July 27, 2018Publication date: February 28, 2019Inventors: Uma LAKSHMIPATHY, Rene QUINTANILLA, Joanna ASPRER
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Publication number: 20180272000Abstract: The invention relates to methods of altering gene expression by homologous recombination in a multipotent adult progenitor cell (MAPC). In particular, methods of producing a recombinant MAPC, of correcting a genetic defect in a mammal, of providing a functional and/or therapeutic protein to a mammal, and of transforming a MAPC are provided. MAPCs containing an erogenous DNA as well as recombinant MAPCs and their differentiated progeny are also provided.Type: ApplicationFiled: September 19, 2017Publication date: September 27, 2018Applicants: ABT Holding Company, Regents of the University of MinnesotaInventors: Catherine M. Verfaillie, Uma Lakshmipathy
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Patent number: 10073096Abstract: Provided herein are compositions, methods and uses that relate to or result from the identification of markers that can distinguish between cells at different stages of pluripotency. Certain embodiments provide markers that can distinguish between parental cells (i.e. differentiated cells), partially pluripotent (i.e. partially reprogrammed) and pluripotent (i.e. fully reprogrammed cells). Also provided here are uses of such differential markers, for example, in identification of cell potential, in diagnostics, in differential separation, and in creating efficient workflows that involve fewer steps and lesser time in identifying or separating a desired reprogrammed clone or cell line from a mixture of cells at various stages of pluripotency. In certain embodiments, the activity of these markers can be manipulated to influence cell potential for research or medical purposes.Type: GrantFiled: March 14, 2013Date of Patent: September 11, 2018Assignee: Life Technologies CorporationInventors: Uma Lakshmipathy, Rene Quintanilla, Joanna Asprer
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Patent number: 9764044Abstract: The invention relates to methods of altering gene expression by homologous recombination in a multipotent adult progenitor cell (MAPC). In particular, methods of producing a recombinant MAPC, of correcting a genetic defect in a mammal, of providing a functional and/or therapeutic protein to a mammal, and of transforming a MAPC are provided. MAPCs containing an erogenous DNA as well as recombinant MAPCs and their differentiated progeny are also provided.Type: GrantFiled: May 21, 2010Date of Patent: September 19, 2017Assignee: ABT HOLDING COMPANYInventors: Catherine Verfaillie, Uma Lakshmipathy
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Publication number: 20160290994Abstract: The invention relates to novel substrates and methods for staining live stem cells. The stain may be used to identify induced pluripotent stem cell colonies during the process of somatic cell reprogramming.Type: ApplicationFiled: April 4, 2016Publication date: October 6, 2016Inventors: Uma LAKSHMIPATHY, Upinder SINGH, Scott GRECIAN, Rene QUINTANILLA, Kyle GEE, Mahendra RAO
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Patent number: 9334523Abstract: The invention relates to novel substrates and methods for staining live stem cells. The stain may be used to identify induced pluripotent stem cell colonies during the process of somatic cell reprogramming.Type: GrantFiled: February 14, 2012Date of Patent: May 10, 2016Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Uma Lakshmipathy, Upinder Singh, Scott Grecian, Rene Quintanilla, Kyle Gee, Mahendra Rao
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Publication number: 20160010113Abstract: The disclosure relates generally to genetic manipulation of stem and primary cells and to reprogramming of somatic cells, more specifically, human cells. In particular, compositions and methods are disclosed for the generation and maintenance of such engineered cells.Type: ApplicationFiled: July 16, 2015Publication date: January 14, 2016Inventors: Uma LAKSHMIPATHY, Bhaskar Thyagarajan, Jonathan Chesnut, Vasiliki Anest, Robert Bennett, Pauline Lieu, George Hanson, David Thompson, Lucas Chase, Gary Shipley, Elizabeth Wilson
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Publication number: 20150247852Abstract: Provided herein are compositions, methods and uses that relate to or result from the identification of markers that can distinguish between cells at different stages of pluripotency. Certain embodiments provide markers that can distinguish between parental cells (i.e. differentiated cells), partially pluripotent (i.e. partially reprogrammed) and pluripotent (i.e. fully reprogrammed cells). Also provided here are uses of such differential markers, for example, in identification of cell potential, in diagnostics, in differential separation, and in creating efficient workflows that involve fewer steps and lesser time in identifying or separating a desired reprogrammed clone or cell line from a mixture of cells at various stages of pluripotency. In certain embodiments, the activity of these markers can be manipulated to influence cell potential for research or medical purposes.Type: ApplicationFiled: March 14, 2013Publication date: September 3, 2015Inventors: Uma Lakshmipathy, Rene Quintanilla, Joanna Asprer
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Publication number: 20130323770Abstract: The invention relates to novel substrates and methods for staining live stem cells. The stain may be used to identify induced pluripotent stem cell colonies during the process of somatic cell reprogramming.Type: ApplicationFiled: February 14, 2012Publication date: December 5, 2013Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Uma Lakshmipathy, Upinder Singh, Scott Grecian, Rene Quintanilla, Kyle Gee, Mahendra Rao
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Publication number: 20130040304Abstract: The disclosure relates generally to genetic manipulation of stem and primary cells and to reprogramming of somatic cells, more specifically, human cells. In particular, compositions and methods are disclosed for the generation and maintenance of such engineered cells.Type: ApplicationFiled: August 9, 2012Publication date: February 14, 2013Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: UMA LAKSHMIPATHY, BHASKAR THYAGARAJAN, JONATHAN CHESNUT, VASILIKI ANEST, ROBERT BENNETT, PAULINE LIEU, GEORGE HANSON, DAVID THOMPSON, LUCAS CHASE, GARY SHIPLEY, ELIZABETH WILSON
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Publication number: 20130004946Abstract: The disclosure relates generally to stem cell biology and more specifically to genetic manipulation of stem cells. Methods and compositions using recombinational cloning techniques are disclosed which allow the construction and insertion of complex genetic constructs into embryonic and adult stem cells and progenitor cells. The methods disclosed will allow the harvesting of adult stem cells pre-engineered with integration sites to facilitate early passage genetic modification.Type: ApplicationFiled: April 16, 2012Publication date: January 3, 2013Applicant: Life Technologies CorporationInventors: Jonathan Chesnut, Bhaskar Thyagarajan, Antje Taliana, Pauline Lieu, Mahendra Rao, Robert Bennett, Robert Burrier, Uma Lakshmipathy, Ying Liu
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Publication number: 20110263001Abstract: The disclosure relates generally to genetic manipulation of stem and primary cells and to reprogramming of somatic cells, more specifically, human cells. In particular, compositions and methods are disclosed for the generation and maintenance of such engineered cells.Type: ApplicationFiled: November 13, 2009Publication date: October 27, 2011Applicant: Life Technologies CorporationInventors: Uma Lakshmipathy, Bhaskar Thyagarajan, Jonathan Chesnut, Vasiliki Anest, Robert Bennett, Pauline Lieu, George Hanson, David Thompson, Lucas Chase, Gary Shipley, Elizabeth Wilson
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Publication number: 20100285590Abstract: The invention relates to methods of altering gene expression by homologous recombination in a multipotent adult progenitor cell (MAPC). In particular, methods of producing a recombinant MAPC, of correcting a genetic defect in a mammal, of providing a functional and/or therapeutic protein to a mammal, and of transforming a MAPC are provided. MAPCs containing an erogenous DNA as well as recombinant MAPCs and their differentiated progeny are also provided.Type: ApplicationFiled: May 21, 2010Publication date: November 11, 2010Applicants: ABT HOLDING COMPANY, REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Catherine Verfaillie, Uma Lakshmipathy
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Publication number: 20080311084Abstract: The present invention relates to MAPCs and progeny derived therefrom to provide lymphohematopoietic cells in a tissue of the lymphohematopoietic system of a subject.Type: ApplicationFiled: July 29, 2005Publication date: December 18, 2008Inventors: Catherine M. Verfaillie, Uma Lakshmipathy, Marta Serafini, Shannon Buckley
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Publication number: 20060228798Abstract: The invention relates to methods of altering gene expression by homologous recombination in a multipotent adult progenitor cell (MAPC). In particular, methods of producing a recombinant MAPC, of correcting a genetic defect in a mammal, of providing a functional and/or therapeutic protein to a mammal, and of transforming a MAPC are provided. MAPCs containing an erogenous DNA as well as recombinant MAPCs and their differentiated progeny are also provided.Type: ApplicationFiled: November 25, 2003Publication date: October 12, 2006Inventors: Catherine Verfaillie, Uma Lakshmipathy