Abstract: Provided herein are compounds useful for imaging granzyme B. An exemplary compound provided herein is useful as a radiotracer for position emission tomography (PET) and/or single photon emission tomography (SPECT) imaging. Methods of imaging granzyme B, combination therapies, and kits comprising the granzyme B imaging agents are also provided.

Abstract: Provided herein are compounds useful for imaging granzyme B. An exemplary compound provided herein is useful as a radiotracer for position emission tomography (PET) and/or single photon emission tomography (SPECT) imaging. Methods of imaging granzyme B, combination therapies, and kits comprising the granzyme B imaging agents are also provided.

Abstract: Provided herein are compositions useful for imaging HER3. An exemplary composition provided herein is useful as a radiotracer for position emission tomography (PET) imaging. Methods of imaging HER3 and combination therapies comprising the HER3 imaging agents are also provided.

Abstract: Provided herein are compositions useful for imaging HER3. An exemplary composition provided herein is useful as a radiotracer for position emission tomography (PET) imaging. Methods of imaging HER3 and combination therapies comprising the HER3 imaging agents are also provided.

Abstract: Provided herein are compositions useful for imaging HER3. An exemplary composition provided herein is useful as a radiotracer for position emission tomography (PET) imaging. Methods of imaging HER3 and combination therapies comprising the HER3 imaging agents are also provided.

Abstract: An optical imaging method for analyzing an ex vivo tissue sample of a subject is provided. The method includes obtaining the ex vivo tissue sample, preparing the ex vivo tissue sample onto a sample receptacle of an optical imaging system, and emitting excitation light toward the ex vivo tissue sample. The method also includes acquiring imaging data of light emitted by the ex vivo tissue sample in response to the excitation light, analyzing the imaging data to determine whether the ex vivo tissue sample contains pathologic tissue, and generating an output indicating to an operator whether the ex vivo tissue sample contains pathologic tissue.

Abstract: Provided herein are compounds useful for imaging granzyme B. An exemplary compound provided herein is useful as a radiotracer for position emission tomography (PET) and/or single photon emission tomography (SPECT) imaging. Methods of imaging granzyme B, combination therapies, and kits comprising the granzyme B imaging agents are also provided.

Abstract: An interventional optical molecular imaging system and method are provided for use with a biopsy introducer needle. The system includes an imaging tool configured to slide coaxially through the biopsy introducer needle toward a tip of the biopsy introducer needle. The system also includes a laser illumination source coupled to the imaging tool, a camera configured to capture images from the imaging tool, and a computer coupled to the camera and the laser illumination source. The computer includes a processor configured to activate the laser illumination source to emit light through a tip of the imaging tool, collect imaging data from the camera after activating the laser illumination source, analyze the imaging data to determine a fluorescence measurement at the tip of the imaging tool, and display an indication of the fluorescence measurement.

Abstract: An optical imaging method for analyzing an ex vivo tissue sample of a subject is provided. The method includes obtaining the ex vivo tissue sample, preparing the ex vivo tissue sample onto a sample receptacle of an optical imaging system, and emitting excitation light toward the ex vivo tissue sample. The method also includes acquiring imaging data of light emitted by the ex vivo tissue sample in response to the excitation light, analyzing the imaging data to determine whether the ex vivo tissue sample contains pathologic tissue, and generating an output indicating to an operator whether the ex vivo tissue sample contains pathologic tissue.

Abstract: An intramolecularly-quenched, near infrared fluorescence probe that emits substantial fluorescence only after interaction with a target tissue (i.e., activation) is disclosed. The probe includes a polymeric backbone and a plurality of near infrared fluorochromes covalently linked to the backbone at fluorescence-quenching interaction-permissive positions separable by enzymatic cleavage at fluorescence activation sites. The probe optionally includes protective chains or fluorochrome spacers, or both. Also disclosed are methods of using the intramolecularly-quenched, near infrared fluorescence probes for in vivo optical imaging.

Abstract: An imaging system divides image pixels intensities by exposure time to generate image data in units of intensity per time. The imaging system divides a fluorescent light image in intensity per time units by an excitation light image in intensity per time units to provide a quantitative corrected fluorescent light image that is generally invariant to position of an imaging instrument relative to a biological tissue being imaged.

Abstract: An imaging system divides image pixels intensities by exposure time to generate image data in units of intensity per time. The imaging system divides a fluorescent light image in intensity per time units by an excitation light image in intensity per time units to provide a quantitative corrected fluorescent light image that is generally invariant to position of an imaging instrument relative to a biological tissue being imaged.

Abstract: An imaging system divides image pixels intensities by exposure time to generate image data in units of intensity per time. The imaging system divides a fluorescent light image in intensity per time units by an excitation light image in intensity per time units to provide a quantitative corrected fluorescent light image that is generally invariant to position of an imaging instrument relative to a biological tissue being imaged.

Abstract: The invention relates to activatable imaging probes that include a chromophore attachment moiety and a plurality of chromophores, such as near-infrared chromophores, chemically linked to the chromophore attachment moiety so that upon activation of the imaging probe by interaction with a target molecule the optical properties of the plurality of chromophores are altered. The probe optionally includes protective chains or chromophore spacers, or both. Also disclosed are methods of using the imaging probes for in vivo and in vitro optical imaging.

Abstract: Described are non-invasive methods for imaging pancreatic inflammation in living mammals using Magnetic Nanoparticle Probes (MNPs).

Abstract: This invention relates essential oil constituents citronellol and rose oxides and other constituents from a cold desert plant i.e. Dracocephalum heterophyllum benth, the present invention also provides a process for the extraction of the essential oil.

Abstract: A beam splitter array includes first and second beam splitters and a reflector to reflect part of a beam from the second splitter. The first splitter outputs a first beam having a power spectral density comprising a substantial portion of a white light spectrum from a first output port, and a second beam of optical radiation having a power spectral density comprising a substantial portion of a first non-white spectrum and a substantial portion of a second non-white spectrum from a second output port, from an input beam received at a first angle of incidence. The second splitter receives the second beam at a second incidence angle, and reflects a substantial portion of the second beam having a power spectral density comprising the first non-white light spectrum, and transmits a substantial portion of the second beam having a power spectral density comprising the second non-white light spectrum.

Abstract: An imaging system divides image pixels intensities by exposure time to generate image data in units of intensity per time. The imaging system divides a fluorescent light image in intensity per time units by an excitation light image in intensity per time units to provide a quantitative corrected fluorescent light image that is generally invariant to position of an imaging instrument relative to a biological tissue being imaged.

Abstract: An intramolecularly-quenched, near infrared fluorescence probe that emits substantial fluorescence only after interaction with a target tissue (i.e., activation) is disclosed. The probe includes a polymeric backbone and a plurality of near infrared fluorochromes covalently linked to the backbone at fluorescence-quenching interaction-permissive positions separable by enzymatic cleavage at fluorescence activation sites. The probe optionally includes protective chains or fluorochrome spacers, or both. Also disclosed are methods of using the intramolecularly-quenched, near infrared fluorescence probes for in vivo optical imaging.

Abstract: This invention relates essential oil constituents citronellol and rose oxides and other constituents from a cold desert plant i.e. Dracocephalum heterophyllum benth, the present invention also provides a process for the extraction of the essential oil.