Abstract: A system described herein may provide for multiple levels of authentication, such that a User Equipment (“UE”) may receive secure content from an application server, which may include or may be implemented by a multi-access edge computing (“MEC”) system. As described herein, a user associated with a UE may register the UE and/or a particular application with an authentication system and/or the application server. The registration of the UE and/or the application may establish a “trust” relationship between the authentication system and the UE, such that a user-level authentication performed by the UE, such as biometric authentication, may be accepted by the authentication system and/or the application system as an authentication of the user.

Abstract: Conductive thick film compositions compatible to aluminum nitride, alumina and silicon nitride substrates for microelectronic circuit application. The conductive thick film composition includes first copper powder, second copper powder, and glass component. The conductive thick film composition further includes CU2O, Ag, and at least one metal element selected from Ti, V, Zr, Mn, Cr, Co, and Sn. After firing, the conductive thick film composition exhibit improved sheet resistivity, and improved adhesion with underlying substrate.

Abstract: A device may receive, from a user equipment, a token request associated with an application, wherein the token request is associated with a device identifier. The device may generate a device token for the application and the user equipment. The device may provide, using the device identifier, the device token to the user equipment to enable a user to access the application via an application platform. The device may receive, from the application platform, a slice request for a network slice of a network that is to be used for an application session. The device may determine that the user equipment is associated with the application session based on the device token and the device identifier. The device may configure a network slice instance of the network slice. The device may determine a user equipment route selection policy for the application session according to the network slice instance.

Abstract: A network device may determine, based on a provisioning request to host an application platform, a configuration of resources of a network for maintaining the application platform within the network. The network device may provision the resources to permit access to the application platform via a domain. The network device may receive, from a user device, a domain request that includes the domain, wherein the domain request is associated with configuring an application session between an application of the user device and the application platform. The network device may provide, to the user device, a response that includes an address of a host resource of the application platform, wherein the host resource is one of the resources. The network device may receive, from the user device, a session request that includes the address and may establish the application session between the user device and the host resource.

Abstract: A device may receive, from a user equipment, a token request associated with an application, wherein the token request is associated with a device identifier. The device may generate a device token for the application and the user equipment. The device may provide, using the device identifier, the device token to the user equipment to enable a user to access the application via an application platform. The device may receive, from the application platform, a slice request for a network slice of a network that is to be used for an application session. The device may determine that the user equipment is associated with the application session based on the device token and the device identifier. The device may configure a network slice instance of the network slice. The device may determine a user equipment route selection policy for the application session according to the network slice instance.

Abstract: This disclosure describes systems, devices, and techniques for implementing master rules in firewalls. In some cases, at least one master rule is identified. The at least one master rule can be associated with performing at least one first operation on a first type of data traffic that satisfies at least one first condition. Multiple firewalls may implement the at least one master rule. In addition, a first firewall among the multiple firewalls may implement at least one application-specific rule in addition to the at least one master rule. The at least one application-specific rule may be associated with performing at least one second operation on a second type of data traffic that satisfies at least one second condition. The multiple firewalls may be between multiple applications and at least one network. Specifically, the first firewall may be deployed between a first application among the multiple applications and the network(s).

Abstract: A device may receive, from a user equipment, a token request associated with an application, wherein the token request is associated with a device identifier. The device may generate a device token for the application and the user equipment. The device may provide, using the device identifier, the device token to the user equipment to enable a user to access the application via an application platform. The device may receive, from the application platform, a slice request for a network slice of a network that is to be used for an application session. The device may determine that the user equipment is associated with the application session based on the device token and the device identifier. The device may configure a network slice instance of the network slice. The device may determine a user equipment route selection policy for the application session according to the network slice instance.

Abstract: A network device may determine, based on a provisioning request to host an application platform, a configuration of resources of a network for maintaining the application platform within the network. The network device may provision the resources to permit access to the application platform via a domain. The network device may receive, from a user device, a domain request that includes the domain, wherein the domain request is associated with configuring an application session between an application of the user device and the application platform. The network device may provide, to the user device, a response that includes an address of a host resource of the application platform, wherein the host resource is one of the resources. The network device may receive, from the user device, a session request that includes the address and may establish the application session between the user device and the host resource.

Abstract: Nanoparticle based MKT formulation. MKT is encapsulated by poly(ethylene glycol)ylated (PEGylated) poly-(lactide-co-glycolide) (PLGA) to form nanoparticles (NPs). To induce trans-BBB permeability, glutathione (GSH) is coated on the resulting NPs. Newly generated MKT-NPs showed BBB permeability and tau reduction in experimental models. Specifically, brain-targeting MKT NPs were developed with a glutathione coating, characterized, and shown to permeate BBB permeation insert models as a therapeutic for Alzheimer's disease and related tauopathies.

Abstract: A method for encoding and decoding a javascript object notation (JSON) document utilizing a statistical tree representing a JSON Schema. The encoded statistical tree may be optimized.

Abstract: A system described herein may provide for multiple levels of authentication, such that a User Equipment (“UE”) may receive secure content from an application server, which may include or may be implemented by a multi-access edge computing (“MEC”) system. As described herein, a user associated with a UE may register the UE and/or a particular application with an authentication system and/or the application server. The registration of the UE and/or the application may establish a “trust” relationship between the authentication system and the UE, such that a user-level authentication performed by the UE, such as biometric authentication, may be accepted by the authentication system and/or the application system as an authentication of the user.

Abstract: Structures that include a peaking inductor and a T-coil, and methods associated with forming such structures. A back-end-of-line interconnect structure includes a first metallization level, a second metallization level, and a third metallization level arranged between the first metallization level and the second metallization level. The T-coil includes a first inductor with a first coil arranged in the first metallization level and a second inductor with a second coil arranged in the second metallization level. A peaking inductor includes a coil arranged in the third metallization level. The first coil of the first inductor, the second coil of the second inductor, and the coil of the peaking inductor are stacked in the back-end-of-line interconnect structure with an overlapping arrangement.

Abstract: A delivery system of coated and uncoated nanoparticles (NP) for delivery of methylene blue (MB). The delivery system was developed using PLGA-based polymer that was repeatedly shown to be biocompatible and biodegradable. The parameters of synthesized NPs were within the suitable range for BBB permeation—specifically, the NPs were monodispersed, with slight negative charge, and with the size within 100-150 nm range suitable for intravenous delivery and delivery to the brain. The coating on the nanoparticle did not have a significant impact on the nanoparticle size and zeta potential. Based on the immunoblotting experiments using AD cellular model, the GSH coated NPs were better in reducing tau levels compared to MB solution. In vitro BBB Transwell permeation study showed eight fold higher MB-NP permeation compared to the MB solution over 24 hours.

Abstract: Nanoparticle based MKT formulation. MKT is encapsulated by poly(ethylene glycol)ylated (PEGylated) poly-(lactide-co-glycolide) (PLGA) to form nanoparticles (NPs). To induce trans-BBB permeability, glutathione (GSH) is coated on the resulting NPs. Newly generated MKT-NPs showed BBB permeability and tau reduction in experimental models. Specifically, brain-targeting MKT NPs were developed with a glutathione coating, characterized, and shown to permeate BBB permeation insert models as a therapeutic for Alzheimer's disease and related tauopathies.

Abstract: Disclosed herein are compositions and methods for treating tauopathies such as Alzheimer's disease (AD). Also provided herein are methods of reducing or disrupting tau aggregation in a subject, and methods of reducing tau protein in a subject. The methods may include administering to the subject a therapeutic amount of hexachlorophene, or a pharmaceutically acceptable salt thereof. Further provided herein are pharmaceutical compositions comprising hexachlorophene, or a pharmaceutically acceptable salt thereof, for the treatment of a tauopathy in a subject.

Abstract: A network management entity is configured to communicate with one or more network security devices. Each network security device is configured to store in a respective event queue an event for each attempt to access a network accessible destination through the security device. Each event indicates the destination of the attempted access. The management entity periodically collects from the event queues the stored events so that less that all of the events stored in the event queues over a given time period are collected. The management entity determines, based on the collected events, top destinations as the destinations that occur most frequently in the collected events. The management entity determines, based on the collected events, bottom destinations as the destinations that occur least frequently in the collected events. The management entity generates for display indications of the top destinations and generates for display indications of the bottom destinations.

Abstract: In some examples, a method for data center forecasting can include: collecting operation data about a data center, the data including data at the application layer, the operating environment layer, and the infrastructure layer; creating a supervised machine learning model based on the collected data; forecasting expected state, capacity, and growth rate of the data center based on the created model; and performing an automated preemptive action based on the forecast.

Abstract: Disclosed herein are compositions and methods for treating tauopathies such as Alzheimer's disease (AD). Also provided herein are methods of reducing or disrupting tau aggregation in a subject, and methods of reducing tau protein in a subject. The methods may include administering to the subject a therapeutic amount of hexachlorophene, or a pharmaceutically acceptable salt thereof. Further provided herein are pharmaceutical compositions comprising hexachlorophene, or a pharmaceutically acceptable salt thereof, for the treatment of a tauopathy in a subject.

Abstract: Disclosed herein are compositions and methods for treating tauopathies such as Alzheimer's disease (AD). Also provided herein are methods of reducing or disrupting tau aggregation in a subject, and methods of reducing tau protein in a subject. The methods may include administering to the subject a therapeutic amount of hexachlorophene, or a pharmaceutically acceptable salt thereof. Further provided herein are pharmaceutical compositions comprising hexachlorophene, or a pharmaceutically acceptable salt thereof, for the treatment of a tauopathy in a subject.

Abstract: Embodiments of the present disclosure provide an integrated circuit (IC) structure including: a first conductive layer of a device structure; a second conductive layer of the device structure vertically separated from the first conductive layer, wherein a load resistor couples the second conductive layer to ground; a t-coil having a first end coupled to the first conductive layer, and a second end coupled to the second conductive layer; and a variable capacitor having a first end coupled to the first conductive layer, and a second end coupled to the second conductive layer, the variable capacitor having an adjustable capacitance.