Patents by Inventor University of Pennsylvania
University of Pennsylvania has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20130309205Abstract: A recombinant vector comprises simian adenovirus 36, simian adenovirus 42.1, simian adenovirus 42.2 and/or simian adenovirus 44 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses one or more simian adenovirus-36, -42.1, -42.2 or -44 gene(s) is also described. Methods of using the vectors and cell lines are provided.Type: ApplicationFiled: May 21, 2013Publication date: November 21, 2013Applicant: The Trustees of the University of PennsylvaniaInventor: The Trustees of the University of Pennsylvania
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Publication number: 20130216506Abstract: The present invention relates to a bioreactor apparatus, and methods of use, for the isolation of rare blood cells, including hematopoietic stem cells and megakaryocytes. The apparatus includes a soft substrate and an anti-contractility agent, thereby providing a soft microenvironment to cultured cells. The apparatus of the invention is permissive for the survival of non-dividing cells while dividing cells are eliminated. This unique property allows for the simple isolation of rare blood cells without the use of costly equipment and antibodies.Type: ApplicationFiled: February 21, 2013Publication date: August 22, 2013Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventor: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
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Publication number: 20130217857Abstract: Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed.Type: ApplicationFiled: April 25, 2013Publication date: August 22, 2013Applicant: The Trustees of the University of PennsylvaniaInventor: The Trustees of the University of Pennsylvania
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Publication number: 20130217122Abstract: The present invention encompasses a method for expanding an antigen specific T cell from a population of cells. The method of the present invention comprises contacting a population of cells with an MHC restricted antigenic glypican-3 peptide. In some instances, the T cell is expanded using monocyte-derived dendritic cells and defined MHC restricted antigenic glypican-3 peptides. In one embodiment, high-affinity antigen-specific T-cell receptors (TCRs) can be cloned from the antigen specific T cell.Type: ApplicationFiled: February 21, 2013Publication date: August 22, 2013Applicants: The Trustees of the University of Pennsylvania, VeteranInventors: The Trustees of the University of Pennsylvania, Government of the United States of America as Represented by the Secretary of the Department of Veteran
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Publication number: 20130216500Abstract: A method for treating an ocular disorder characterized by the defect or absence of a normal gene in the ocular cells of a human or animal subject involves administering to the subject by subretinal injection an effective amount of a recombinant adeno-associated virus carrying a nucleic acid sequence encoding the normal gene under the control of a promoter sequence which expresses the product of the gene in the ocular cells. The ocular cells are preferably retinal pigment epithelial (RPE) cells, and the gene is preferably an RPE-specific gene, e.g., RPE65. The promoter is one that can express the gene product in the RPE cells. Compositions for subretinal administration are useful in this method.Type: ApplicationFiled: February 13, 2013Publication date: August 22, 2013Applicants: The Trustees of the University of Pennsylvania, Cornell Research Foundation, Inc., University of Florida Research Foundation, IncorporatedInventors: The Trustees of the University of Pennsylvania, University of Florida Research Foundation, Incorporated, Cornell Research Foundation, Inc.
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Publication number: 20130209980Abstract: Systems and methods for training an operator of a robotic surgery system are disclosed. One such method includes enabling the operator to perform a test procedure, recording vibrations of a surgical tool of the robotic surgery system during the test procedure, and generating a score for the operator based at least in part on the recorded vibrations of the surgical tool.Type: ApplicationFiled: March 15, 2013Publication date: August 15, 2013Inventor: The Trustees of the University of Pennsylvania
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Publication number: 20130204069Abstract: Methods of treating an individual who has an erbB protein mediated tumor is disclosed. Methods of preventing erbB protein mediated tumors in an individual are disclosed. The methods comprise administering to the individual a nucleic acid molecule that encodes a protein that dimerizes with an erbB protein and that is deficient in tyrosine kinase activity. Composition that comprise such nucleic acid molecules including pharmaceutical compositions are disclosed.Type: ApplicationFiled: March 12, 2013Publication date: August 8, 2013Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventor: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
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Publication number: 20130202173Abstract: A method and apparatus for classifying possibly vulnerable plaques from sets of DCE-MRI images includes receiving a set of MRI slice images obtained at respectively different times, where each slice image includes voxels representative of at least one region of interest (ROI). The images are processed to determine the boundaries of the ROIs and the voxels within the identified boundaries in corresponding regions of the images from each time period are processed to extract kinetic texture features. The kinetic texture features are then used in a classification process which classifies the ROIs as vulnerable or stable.Type: ApplicationFiled: January 2, 2013Publication date: August 8, 2013Applicants: vascuVis Inc., The Trustees Of The University of Pennsylvania, Trustees of Boston University, Rutgers, The state University of New JerseyInventors: vascuVis Inc., Rutgers, The state University of New Jersey, Trustees of Boston University, The Trustees Of The University of Pennsylvania
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Publication number: 20130197068Abstract: This invention provides RNA, oligoribonucleotide, and polyribonucleotide molecules comprising pseudouridine or a modified nucleoside, gene therapy vectors comprising same, methods of synthesizing same, and methods for gene replacement, gene therapy, gene transcription silencing, and the delivery of therapeutic proteins to tissue in vivo, comprising the molecules. The present invention also provides methods of reducing the immunogenicity of RNA, oligoribonucleotide, and polyribonucleotide molecules.Type: ApplicationFiled: March 15, 2013Publication date: August 1, 2013Applicant: The Trustees Of The University Of PennsylvaniaInventor: The Trustees Of The University Of Pennsylvania
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Publication number: 20130196346Abstract: The present invention relates to methods and kits for diagnosing, ascertaining the clinical course of myelodysplastic syndrome (MDS) and ascertaining response to a therapy regimen of myelodysplastic syndrome. Specifically the invention provides methods and kits useful in the diagnosis and determination of clinical parameters associated with MDS based on surface markers unique to MDS.Type: ApplicationFiled: January 11, 2013Publication date: August 1, 2013Applicant: The Trustees of the University of PennsylvaniaInventor: The Trustees of the University of Pennsylvania
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Publication number: 20130190254Abstract: Polypeptides which bind to the helical transmembrane region of membrane proteins are disclosed, as are methods for the design of polypeptides that bind to the transmembrane region of membrane proteins. Also provided are methods for the use of the disclosed polypeptides in various applications, as well as products made through the practice of the instant methods.Type: ApplicationFiled: December 5, 2012Publication date: July 25, 2013Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventor: The Trustees of the University of Pennsylvania
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Publication number: 20130186758Abstract: Disclosed are devices that feature nanopores formed in graphene sheets, such as graphene ribbons. The graphene sheets include an edge irregularity, such as a zig-zag configuration, a chiral edge, or an armchair-configuration edge, which edges confer on the devices the ability to discriminate between different subunits of a macromolecule translocated through the nanpore. The disclosed devices and methods have application to DNA sequencing and analysis, among other applications.Type: ApplicationFiled: December 5, 2012Publication date: July 25, 2013Applicants: University Of Delaware, The Trustees Of The University Of PennsylvaniaInventors: The Trustees Of The University Of Pennsylvania, University Of Delaware
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Publication number: 20130189241Abstract: The invention relates to a controlled release delivery compositions and methods of using them for pathologies associated with Otorhinolaryngology and Head and Neck. Specifically, the invention relates to regulating drug delivery by the use of chitosan based matrices together with chitosanases.Type: ApplicationFiled: December 21, 2012Publication date: July 25, 2013Applicant: The Trustees of the University of PennsylvaniaInventor: The Trustees of the University of Pennsylvania
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Publication number: 20130190321Abstract: Methods and kits for aiding in detection, assessment and treatment of a proliferative disorder of the prostate gland in a subject are provided according to aspects of the present invention which include assaying a first biological sample comprising prostate gland cells obtained from the subject for expression of one or more biomarkers selected from the group consisting of: alcohol dehydrogenase 1B, alcohol dehydrogenase 1C, alcohol dehydrogenase 4 and hepatocyte nuclear factor 1B; and determining, based on the expression of the one or more biomarkers in the sample that the subject has, or is at risk of having, a proliferative disorder of the prostate gland.Type: ApplicationFiled: January 23, 2013Publication date: July 25, 2013Applicant: WEST CHESTER UNIVERSITY OF PENNSYLVANIAInventor: West Chester University of Pennsylvania
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Publication number: 20130189698Abstract: The present invention pertains to methods related to cloning nucleic acids from biological samples, particularly pathological tissue samples. This method includes hybridizing a population of oligonucleotide sequence probes comprising degenerate sequence tags to a fixed tissue, isolating the hybridized oligonucleotide sequence probes and amplifying the sequence tags in the hybridized oligonucleotide sequence probes. This method can be utilized to identify genes associated with disease and to quantitate the expression of disease-related transcripts. The method can also be used to identify truncated mRNAs.Type: ApplicationFiled: March 21, 2013Publication date: July 25, 2013Applicant: The Trustees of the University of PennsylvaniaInventor: The Trusfees of the University of Pennsylvania
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Publication number: 20130184441Abstract: Provided are methods of assessing the absence or presence of a neurodegenerative disease in a subject comprising characterizing TDP-43 in a tissue sample of the subject. Also disclosed are methods for diagnosing a neurodegenerative disease in a subject, and methods for determining the efficacy of a drug against a neurodegenerative disease. Novel antibodies that bind to TDP-43 are also provided.Type: ApplicationFiled: December 12, 2012Publication date: July 18, 2013Applicant: The Trustees of the University of PennsylvaniaInventor: The Trustees of the University of Pennsylvania
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Publication number: 20130178440Abstract: The invention provides compositions and methods for treating skin cancer associated diseases. Specifically, the invention relates to topically administering a signaling pathway inhibitor or a related compound to treat pre-cancerous skin lesions, skin tumors, and their associated diseases or disorders.Type: ApplicationFiled: March 6, 2013Publication date: July 11, 2013Applicant: The Trustees of the University of PennsylvaniaInventor: The Trustees of the University of Pennsylvania
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Publication number: 20130165488Abstract: The present invention relates to novel TP receptor antagonists, which optionally cross the blood-brain barrier of a mammal. The invention also provides methods for treating a disorder related to activation of TP receptor utilizing the compounds of the invention.Type: ApplicationFiled: February 28, 2013Publication date: June 27, 2013Applicant: The Trustees of the University of PennsylvaniaInventor: The Trustees of the University of Pennsylvania
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Publication number: 20130158058Abstract: This invention provides compositions and methods of inhibiting, suppressing, or treating a tendinous or musculoskeletal soft tissue injury. The invention further provides a method of ameliorating symptoms associated with a tendinous or musculoskeletal soft tissue injury. Additionally, the invention provides methods for evaluating the risk of developing a tendinous or musculoskeletal soft tissue injury.Type: ApplicationFiled: February 14, 2013Publication date: June 20, 2013Applicant: The Trustees of the University of PennsylvaniaInventor: The Trustees of the University of Pennsylvania
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Publication number: 20130157962Abstract: Methods are provided for inhibiting growth of prolactin-responsive cancer cells and treating prolactin-responsive malignancies via administration an agent such as cyclosporine A which directly inhibits an enzymatic activity of a cyclophilin.Type: ApplicationFiled: January 22, 2013Publication date: June 20, 2013Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventor: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA