Abstract: Systems, methods, and software are provided for assessing manufacturing errors of a prosthetic socket to facilitate a clinical assessment of the socket. The embodiments disclosed herein may align and compare a manufactured socket shape to a desired socket shape to determine whether clinically significant errors are present in the manufactured socket. A mean radial error (MRE) may be calculated and compared to a set threshold. If the MRE falls below the threshold an interquartile range (IQR) may be calculated and compared to an IQR threshold. If the IQR falls below the IQR threshold, surface normal angle errors (SNAE) may be calculated and plotted to the surface model. If the SNAE plot does not include closed contour regions, the socket may proceed to patient fitting. If the MRE or IQR thresholds are exceeded, or if the SNAE plot indicates closed contour regions, the socket may be reshaped accordingly, prior to fitting.

Abstract: A system for routing data along a path that is both efficient and secure is provided. A performance and vulnerability routing system selects a path for routing using a joint metric for a link in a network of nodes. The system calculates the joint metric based on a combination of a performance metric and a vulnerability metric of a link. The performance metric for a link indicates the cost of transmitting data over the link, and the vulnerability metric for the link indicates the security of data that is transmitted over the link. The system combines the performance metric and the vulnerability metric to generate the joint metric, which indicates a joint cost of transmitting data. The system then selects paths for transmitting data that tend to minimize the sum of the joint costs of the links along the paths.

Abstract: Method and system for detecting multiple analytes from a sample material by desorption ionization, mass analysis, and multivariate statistical analysis.

Abstract: By monitoring pressure transients in a liquid within a liquid distribution system using only a single sensor, events such as the opening and closing of valves at specific fixtures are readily detected. The sensor, which can readily be coupled to a faucet bib, transmits an output signal to a computing device. Each such event can be identified by the device based by comparing characteristic features of the pressure transient waveform with previously observed characteristic features for events in the system. These characteristic features, which can include the varying pressure, derivative, and real Cepstrum of the pressure transient waveform, can be used to select a specific fixture where a valve open or close event has occurred. Flow to each fixture and leaks in the system can also be determined from the pressure transient signal. A second sensor disposed at a point disparate from the first sensor provides further event information.

Abstract: The invention provides HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.

Abstract: A method for identifying a target arrhythmia, for example, atrial fibrillation, with very high specificity includes obtaining heart rhythm data such as EKG data, selecting and analyzing a segment of the data for arrhythmia, if an arrhythmia is found then reanalyzing the segment of data for a hidden regularity that would indicate the data is not the target arrhythmia. If no hidden regularity is found, then identifying the segment as the target arrhythmia.

Abstract: Charge transport compounds are provided. The compounds are useful in optoelectronic devices that include the compounds incorporated as a charge-transport layer. Methods for forming films of the compounds are also provided. Additionally, methods are provided for forming films of a charge-transport layer on an active layer of an optoelectronic device. The films are formed from a solution with solubility orthogonal to the solubility of the active layer, such that the active layer is not solvated during deposition of the charge-transport layer.

Abstract: A facility comprising methods and systems for discovering travel patterns based at least in part on data collected from a plurality of dynamic and/or mobile sensor devices is disclosed. The mobile sensor devices sense or detect the presence of nearby devices and record information about each detection, such as the location, the date and time, and an identifier of the detected device and provide this information to the facility. Thus, the facility can leverage the communication capabilities of existing mobile devices and networks to provide a broad, wide-ranging, scalable sensor network that detects the presence of individual devices. By recording and analyzing the encounter data received from various mobile sensor devices, the facility can ascertain or estimate the path of devices and their associated users. Given the availability of mobile devices and mobile networks, the disclosed techniques can be deployed without a substantial investment in infrastructure and maintenance.

Abstract: Environmentally-responsive composites useful for intracellular delivery of therapeutic agents.

Abstract: Devices and methods are provided for generating electrical power using a capacitor. The capacitor has a catalytic working electrode, a dielectric, and a counter electrode. Power is generated by flowing a fuel (e.g., hydrogen gas) over the working electrode, charging the capacitor (e.g. by applying a voltage), flowing an oxidant (e.g., oxygen gas) over the working electrode, and connecting the electrodes to a resistive load, which allows current to flow through the load, between the electrodes. The inverse device (i.e., oxidant first, then fuel) functions similarly.

Abstract: A protocol with constant-time complexity solves the problem of private identification of tags in low-cost, large-scale radio frequency identification (RFID) systems—assuming that an adversary has complete control over the communication channel. Each RFID tag has an internal counter, c, and is preloaded with a unique pseudonym, ?, and a secret key, k. A RFID reader attempting to identify and authenticate a tag within its range generates and transmits a random nonce to the RFID tag, which returns a first hash of its current pseudonym and counter, and a second hash that is a function of the secret key. The reader uses the returned data to identify the RFID tag and its secret key by reference to a database and returns other hash values that authenticate the reader to the RFID tag. The most expensive operation that RFID tags are required to perform is a hash function.

Abstract: Methods are provided for increasing stem cells, hematopoietic progenitor/stem cells, mesenchymal progenitor/stem cells, mesodermal progenitor/stem cells, muscle progenitor/stem cells, or neural progenitor/stem cells in vivo in a mammalian subject. Methods are also provided for treating an immune related disease, a mesenchymal/mesoderm degenerative disease, or a neurodegenerative disease in a mammalian subject in need thereof.

Abstract: A method/apparatus/system for detection of a potential disease state is disclosed. A pair of electrodes is attached to a limb and the electrodes are energized. The energizing of the electrodes creates a first signal in the form of current data. If the first signal is consistent with a potential disease state, including a potential artery-to-vein disease state, an indication of the potential disease state is provided.

Abstract: Described is a method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for T lymphocytes that are specific to a virus that attacks skin. Also provided are HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection that have been identified via the methods of the invention. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.

Abstract: Marine coatings including cationic polymers hydrolyzable to nonfouling zwitterionic polymers, coated marine surfaces, and methods for making and using the marine coatings.

Abstract: The present technology describes various embodiments of systems and methods for remote monitoring of exercise performance metrics. In several embodiments, for example, a method of evaluating an exercise performed by a patient includes providing the patient with a pre-recorded avatar showing an exemplary instance of a prescribed exercise. The method further includes sensing the patient's movement during an exercise session and generating a real-time avatar based on the sensing. The pre-recorded avatar can be overlaid with the real-time avatar. The graphic overlay readily shows the patient whether and where his motion and/or body position deviate from the prescribed exercise. The overlay can be made in real time. In several embodiments, the patient's independently-recorded avatar and/or performance metrics are transmitted to the exercise prescriber to monitor the fidelity with which the patient is able to reproduce the exercise outside the prescriber's supervision.

Abstract: Fullerene surfactant compounds useful as interfacial layer in polymer solar cells to enhance solar cell efficiency. Polymer solar cell including a fullerene surfactant-containing interfacial layer intermediate cathode and active layer.

Abstract: The present invention provides reagents and methods for inhibiting bacterial infection and abnormal cell growth, as well as for selection cloning of nucleic acid inserts.

Abstract: Visual-assisted guidance of an ultra-thin flexible endoscope to a predetermined region of interest within a lung during a bronchoscopy procedure. The region may be an opacity-identified by non-invasive imaging methods, such as high-resolution computed tomography (HRCT) or as a malignant lung mass that was diagnosed in a previous examination. An embedded position sensor on the flexible endoscope indicates the position of the distal tip of the probe in a Cartesian coordinate system during the procedure. A visual display is continually updated, showing the present position and orientation of the marker in a 3-D graphical airway model generated from image reconstruction. The visual display also includes windows depicting a virtual fly-through perspective and real-time video images acquired at the head of the endoscope, which can be stored as data, with an audio or textual account.

Abstract: An acoustic pretouch sensor or proximity sensor (110) includes a cavity (104) with a first microphone (106) disposed therein, and optionally a second microphone (108) disposed outside of the cavity. A processing system (110) receives the signals generated by the first microphone and analyzes the spectrum to produce a result representing the resonant frequency of the cavity. The processing system may optionally subtract the second microphone signal spectrum from the first to automatically compensate for changes in ambient noise. The processing system uses the resonant frequency to estimate the distance from the cavity opening to a surface (90). For example, the pretouch sensors may be incorporated into a stand alone device (100), into a robotic end effector (204), or into a device such as a phone (300).