Patents by Inventor Uthaman Gowthaman

Uthaman Gowthaman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic immunogen useful for generating long lasting immunity and protection against pathogens
    Patent number: 9340622
    Abstract: The present invention relates to a synthetic immunogen represented by the general formula 1, useful for generating long lasting protective immunity against various intracellular pathogens which are the causative agents of tuberculosis, leishmaniasis, AIDS, trypanosomiasis, malaria and also allergy, cancer and a process for the preparation thereof. The developed immunogen is able to circumvent HLA restriction in humans and livestock. The invention further relates to a vaccine comprising the said immunogen for generating enduring protective immunity against various diseases. The said vaccine is targeted against intracellular pathogens, more particularly the pathogen M. tuberculosis in this case. In the present invention, promiscuous peptides of M. tuberculosis are conjugated to TLR ligands especially; Pam2Cys to target them mainly to dendritic cells and therefore elicit long-lasting protective immunity. wherein, X1=a promiscuous CD4 T helper epitope selected from SEQ ID No.
    Type: Grant
    Filed: September 14, 2011
    Date of Patent: May 17, 2016
    Assignees: Council of Scientific & Industrial Research, University of Melbourne
    Inventors: Javed N. Agrewala, Uthaman Gowthaman, David Jackson, Weiguang Zeng
  • SYNTHETIC IMMUNOGEN USEFUL FOR GENERATING LONG LASTING IMMUNITY AND PROTECTION AGAINST PATHOGENS
    Publication number: 20130183377
    Abstract: The present invention relates to a synthetic immunogen represented by the general formula 1, useful for generating long lasting protective immunity against various intracellular pathogens which are the causative agents of tuberculosis, leishmaniasis, AIDS, trypanosomiasis, malaria and also allergy, cancer and a process for the preparation thereof. The developed immunogen is able to circumvent HLA restriction in humans and livestock. The invention further relates to a vaccine comprising the said immunogen for generating enduring protective immunity against various diseases. The said vaccine is targeted against intracellular pathogens, more particularly the pathogen M. tuberculosis in this case. In the present invention, promiscuous peptides of M. tuberculosis are conjugated to TLR ligands especially; Pam2Cys to target them mainly to dendritic cells and therefore elicit long-lasting protective immunity.
    Type: Application
    Filed: September 14, 2011
    Publication date: July 18, 2013
    Applicants: UNIVERSITY OF MELBOURNE, COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Javed Naim Agrewala, Uthaman Gowthaman, David Jackson, Weiguang Zeng