Publication number: 20220118121
Abstract: The present invention relates to a compound of formula (1), and to a complex comprising said compound and a radionuclide, and to the respective pharmaceutical composition, the compound having the following structure or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is H or —CH3, preferably H, wherein R2, R3 and R4 are independently of each other, selected from the group consisting of —CO2H, —SO2H, —SO3H, —OSO3H, —PO2H, —PO3H and —OPO3H2, Q1 is selected from the group consisting of alkylaryl, arylalkyl, aryl, alkylheteroaryl, heteroarylalkyl and heteroaryl, Q2 is selected from the group consisting of aryl, alkylaryl, arylalkyl, cycloalkyl, heterocycloalkyl, heteroaryl, heteroarylalkyl and alkylheteroaryl, A is a chelator residue derived from a chelator selected from the group consisting of 1,4,7,10-tetraazacyclododecane-N,N?,N?,N??-tetraacetic acid (=DOTA), N,N?-bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-N,N?-diacetic acid, 1,4,7-triazacyclononane-1,4,7-triacetic acid (=NOTA),
Type:
Application
Filed:
February 14, 2020
Publication date:
April 21, 2022
Inventors:
Matthias Eder, Ann-Christin Baranski, Michael Eisenhut, Uwe Haberkorn
Publication number: 20210393809
Abstract: The present invention relates to a compound of formula (1) (I), wherein Y3 is O or S, wherein s, t, u and w are 0 or 1, wherein i is an integer of from 1 to 3, wherein j is an integer of from 3 to 5, and wherein Z1, Z2 and Z3 are selected from the group consisting of CO2H, —SO2H, —SO3H, —OSO3H, and -0P03H2, R1 is —CH3 or H, X is selected from the group consisting of alkylaryl, aryl, alkylheteroaryl and heteroaryl, Y1 and Y2 are selected from the group consisting of aryl, alkylaryl, cycloalkyl, heterocycloalkyl, heteroaryl and alkylheteroaryl, and wherein A is a chelator residue having a structure selected from the group consisting of (la), (lb) and (lc), wherein R2, R3, R4 and R5 are selected from the group consisting of H, —CH2—COOH and —CH2—C(=0)-NH2 or wherein R2 and R4 form a —(CH2)n— bridge with n being an integer of from 1 to 3, wherein n is preferably 2, and wherein r, v and q are 0 or 1, with the proviso that in case u and w are 0, q and v are 0, and (A) wherein u and w are 1, or (B) wherein u is 0 an
Type:
Application
Filed:
September 27, 2019
Publication date:
December 23, 2021
Applicants:
Universität Heidelbert, Deutsches Krebsforschungszentrum
Inventors:
Uwe HABERKORN, José Carios DOS SANTOS, Walter MIER, Clemens KRATOCHWIL, Ulrike BAUDER-WUEST, Klaus KOPKA, Martin SCHÄFER