Patents by Inventor Uwe R. Muller

Uwe R. Muller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DETECTION OF DEBRIS IN RECIRCULATING PHAGOCYTES
    Publication number: 20240036065
    Abstract: Methods for detecting neural-derived debris inside or on the cell surface of circulating neutrophils. The methods include single cell analysis of neutrophils and associated neural-derived biomarkers, using assays such as flow cytometry and single cell ELISA. The present invention also features methods for detecting and/or monitoring various states of brain health based on the neural-derived debris in said neutrophils.
    Type: Application
    Filed: October 12, 2023
    Publication date: February 1, 2024
    Inventors: Uwe R. Muller, Vanessa White
  • DETECTION OF NEURAL-DERIVED DEBRIS IN RECIRCULATING PHAGOCYTES
    Publication number: 20220236288
    Abstract: Methods for preparing neural-derived compounds, e.g., the debris such as peptides, nucleic acids, or other compounds that would only normally be found in brain or CNS tissue, from circulating phagocytes. The methods herein may feature extracting lysate from circulating phagocytes obtained from outside central nervous system (CNS) tissue, producing a fraction of the lysate comprising CNS-derived compounds, and analyzing the CNS-derived compounds in the fraction.
    Type: Application
    Filed: April 12, 2021
    Publication date: July 28, 2022
    Inventors: Uwe R. Muller, Ramesh C. Nayak
  • DETECTION OF NEURAL-DERIVED DEBRIS IN RECIRCULATING PHAGOCYTES
    Publication number: 20220236291
    Abstract: Methods for preparing neural-derived compounds, e.g., the debris such as peptides, nucleic acids, or other compounds that would only normally be found in brain or CNS tissue, from circulating phagocytes. The methods herein may feature extracting lysate from circulating phagocytes obtained from outside central nervous system (CNS) tissue, producing a fraction of the lysate comprising CNS-derived compounds, and analyzing the CNS-derived compounds in the fraction.
    Type: Application
    Filed: April 12, 2022
    Publication date: July 28, 2022
    Inventors: Uwe R. Muller, Vanessa White
  • DETECTION OF DEBRIS IN RECIRCULATING PHAGOCYTES
    Publication number: 20220236292
    Abstract: Methods for detecting neural-derived debris inside or on the cell surface of circulating neutrophils. The methods include single cell analysis of neutrophils and associated neural-derived biomarkers, using assays such as flow cytometry and single cell ELISA. The present invention also features methods for detecting and/or monitoring various states of brain health based on the neural-derived debris in said neutrophils.
    Type: Application
    Filed: April 12, 2022
    Publication date: July 28, 2022
    Inventors: Uwe R. Muller, Vanessa White
  • Detectable labels, methods of manufacture and use
    Patent number: 7842516
    Abstract: Labels, methods of making labels and methods of using labels are disclosed. The labels can be manufactured using fiber drawing techniques or by shutter masking. The labels can be used for detecting the presence of an analyte in a sample and for detecting interactions of biomolecules.
    Type: Grant
    Filed: June 30, 2006
    Date of Patent: November 30, 2010
    Assignee: Corning Incorporated
    Inventors: Matthew J. Dejneka, Joydeep Lahiri, Uwe R. Muller, Cameron W. Tanner, Patrick D. Tepesch
  • Method for genotyping DNA tandem repeat sequences
    Publication number: 20100196893
    Abstract: The present invention provides methods for determining the number of tandem repeat units in a region of double stranded DNA based on the use of RecA-like recombinase protein and oligonucleotide ligation. The methods of the present invention provide RecA coated, specific DNA oligonucleotide probes (RecA filaments) for homology searching in duplex DNA where the location of homologous sequences results in the formation of D-loop structures containing a duplex region comprising the oligonucleotide probe and one strand of the target DNA.
    Type: Application
    Filed: October 15, 2009
    Publication date: August 5, 2010
    Applicant: Gene Check, Inc.
    Inventors: Uwe R. Müller, Robert E. Wagner, JR.
  • Ultra-sensitive detection of analytes
    Publication number: 20100035243
    Abstract: The present invention relates to screening methods, compositions, and kits for detecting for the presence or absence of one or more target analytes, e.g. biomolecules, in a sample. In particular, the present invention relates to methods that utilize nanoparticle probes in an in-solution homogeneous assay system for high-sensitivity detection of target proteins or nucleic acids based on flow analysis of single particles.
    Type: Application
    Filed: December 20, 2006
    Publication date: February 11, 2010
    Applicant: Nanosphere, Inc.
    Inventors: Uwe R. Muller, Phil Lefebvre
  • Detectable labels, methods of manufacture and use
    Patent number: 7241629
    Abstract: Labels, methods of making labels and methods of using labels are disclosed. The labels can be manufactured using fiber drawing techniques or by shutter masking. The labels can be used for detecting the presence of an analyte in a sample and for detecting interactions of biomolecules.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: July 10, 2007
    Assignee: Corning Incorporated
    Inventors: Matthew J. Dejneka, Joydeep Lahiri, Uwe R. Muller, Cameron W. Tanner, Patrick D. Tepesch
  • Microvolume biochemical reaction chamber
    Publication number: 20040101870
    Abstract: Methods and apparatus for performing biomolecular reactions using microvolumes of reagents are disclosed. The apparatus and methods include a chamber having a height less than 50 microns and means for mixing the extremely small volume of fluid in the chamber. The decreased volumes combined with mixing greatly improved microarray hybridization signal strength.
    Type: Application
    Filed: March 10, 2003
    Publication date: May 27, 2004
    Inventors: Bruno S. Caubet, Thierry DeLumley, Olivier Lobet, Uwe R. Muller, Jean-Pierre Themont
  • Solid phase detection of nucleic acid molecules
    Publication number: 20030148284
    Abstract: The present invention is directed to a method for detecting a target nucleic acid molecule in a sample. An immobilized oligonucleotide primer is extended using a polymerase, yielding an extension product that can be used in a detection assay. The assay is useful for detecting the presence of a target nucleic acid molecule in a sample and quantifying the amount of the target nucleic acid molecule in the sample. Also disclosed are ways of applying the method of the present invention.
    Type: Application
    Filed: December 17, 2001
    Publication date: August 7, 2003
    Inventors: Todd J. Vision, Amber Carmon, Theodore W. Thannhauser, Stephen Kresovich, Sharon E. Mitchell, Uwe R. Muller
  • Detectable labels, methods of manufacture and use
    Publication number: 20030119207
    Abstract: Labels, methods of making labels and methods of using labels are disclosed. The labels can be manufactured using fiber drawing techniques or by shutter masking. The labels can be used for detecting the presence of an analyte in a sample and for detecting interactions of biomolecules.
    Type: Application
    Filed: December 20, 2001
    Publication date: June 26, 2003
    Inventors: Matthew J. Dejneka, Joydeep Lahiri, Uwe R. Muller, Cameron W. Tanner, Patrick D. Tepesch
  • Methods for detecting genetic aberrations
    Publication number: 20030082618
    Abstract: Methods and DNA microarray devices for detecting or measuring genetic aberrations or changes in genomic DNA using comparative genomic hybridization (CGH) techniques and gene-expression assays are provided.
    Type: Application
    Filed: October 15, 2002
    Publication date: May 1, 2003
    Inventors: Guangshan Li, Uwe R. Muller, Yijia Bao, Xinying Xie, Nalini Raghavachari
  • Processing of slide mounted material
    Patent number: 5273905
    Abstract: An apparatus for the sequential multi-step processing of slide surface portions. The apparatus includes subassemblies and assemblies and a computer driven control system therefor. The apparatus permits at least one step of such a process sequence to be carried out with minimal amounts of processing liquids which is advantageous for specimen treatment with costly reagents, such as aqueous compositions containing probes. Immunochemical and in situ hybridization procedures can be carried out.
    Type: Grant
    Filed: February 22, 1991
    Date of Patent: December 28, 1993
    Assignee: Amoco Corporation
    Inventors: Uwe R. Muller, Lawrence J. Mika, Donald J. Lindley, Ernest J. Wisner