Patents by Inventor Vadym Berkout
Vadym Berkout has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11996279Abstract: Disclosed are systems are methods for identifying the composition of single aerosol particles, particularly that of bioaerosol particles. A continuous timing laser tightly coupled with a pulse ionization laser is used to index aerosol particles, measure particle properties, and trigger the ionization laser to fire when each particle enters the beam of the trigger laser. Ionized fragments and optionally photons produced when each particle is struck by the ionization laser are analyzed using one or more detectors including a TOF-MS detector and an optical detector. Individual single particle spectra are aligned and denoised prior to averaging.Type: GrantFiled: October 21, 2021Date of Patent: May 28, 2024Assignee: ZETEO TECH, INC.Inventors: Michael McLoughlin, Ross Kliegman, Tim Cornish, Vadym Berkout, Scott Ecelberger, Gonzalo Arce, Kyle Regan
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Publication number: 20220044921Abstract: Disclosed are systems are methods for identifying the composition of single aerosol particles, particularly that of bioaerosol particles. A continuous timing laser tightly coupled with a pulse ionization laser is used to index aerosol particles, measure particle properties, and trigger the ionization laser to fire when each particle enters the beam of the trigger laser. Ionized fragments and optionally photons produced when each particle is struck by the ionization laser are analyzed using one or more detectors including a TOF-MS detector and an optical detector. Individual single particle spectra are aligned and denoised prior to averaging.Type: ApplicationFiled: October 21, 2021Publication date: February 10, 2022Applicant: Zeteo Tech, Inc.Inventors: Michael McLoughlin, Ross Kliegman, Tim Cornish, Vadym Berkout, Scott Ecelberger, Gonzalo Arce, Kyle Regan
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Patent number: 10734213Abstract: An intermittent sample inlet device and methods for use of the intermittent sample inlet device are described that include an orifice plate with an entrance orifice and a rotating skimmer with a skimmer orifice, where the rotating skimmer is disposed between the orifice plate and a vacuum chamber wall. The rotating skimmer rotates so that the skimmer orifice intermittently aligns with the entrance orifice and allows an ion sample to pass through to a mass analyzer.Type: GrantFiled: July 31, 2014Date of Patent: August 4, 2020Assignee: Smiths Detection Inc.Inventor: Vadym Berkout
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Patent number: 10629424Abstract: A low temperature plasma probe, a mass spectrometry system, and a method for using a low temperature plasma probe are described. In an embodiment, a low temperature plasma probe includes an intake capillary that provides an ion flow from a sample surface to a mass spectrometer; at least one low temperature plasma tube that provides low temperature plasma gas; at least one heated gas tube that provides heated gas to the sample surface, where the heated gas enhances desorption and ionization of a sample on the sample surface.Type: GrantFiled: August 23, 2018Date of Patent: April 21, 2020Assignee: SMITHS DETECTION INC.Inventors: Vadym Berkout, Thomas D. Saul
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Publication number: 20190131118Abstract: An ion transfer tube assembly, a mass spectrometry system, and a method for providing an ion stream to an ion detection device are described that include using an ion transfer tube that provides a coaxial sheath gas flow. In an implementation, an ion transfer tube assembly includes an ion transfer tube for delivering the ion stream, where a sheath gas flows through the ion transfer tube, and where the ion transfer tube receives the ion stream from a first conduit coupled to an ion source; a pump fluidly coupled to the ion transfer tube, where the pump causes the sheath gas to flow through the ion transfer tube, where the ion stream is separated from the ion transfer tube walls by the coaxial sheath gas flow, and where the ion stream is received by a second conduit coupled to the ion detection device.Type: ApplicationFiled: April 21, 2017Publication date: May 2, 2019Inventors: Vadym Berkout, Douglas J. Green
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Publication number: 20180366309Abstract: A low temperature plasma probe, a mass spectrometry system, and a method for using a low temperature plasma probe are described. In an embodiment, a low temperature plasma probe includes an intake capillary that provides an ion flow from a sample surface to a mass spectrometer; at least one low temperature plasma tube that provides low temperature plasma gas; at least one heated gas tube that provides heated gas to the sample surface, where the heated gas enhances desorption and ionization of a sample on the sample surface.Type: ApplicationFiled: August 23, 2018Publication date: December 20, 2018Inventors: Vadym Berkout, Thomas D. Saul
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Patent number: 10109471Abstract: A sample inlet device and methods for use of the sample inlet device are described that include an ion funnel having a plurality of electrodes with apertures arranged about an axis extending from an inlet of the ion funnel to an outlet of the ion funnel, the ion funnel including a plurality of spacer elements disposed coaxially with the plurality of electrodes, each of the plurality of spacer elements being positioned between one or two adjacent electrodes, each of the plurality of spacer elements having an aperture with a diameter that is greater than a diameter of each adjacent electrode. The ion funnel is configured to pass an ion sample through the apertures of the electrodes and the spacer elements to additional portions of a detection system, such as to a mass analyzer system and detector.Type: GrantFiled: February 6, 2017Date of Patent: October 23, 2018Assignee: Smith Detection, Inc.Inventors: Vadym Berkout, Jan Hendrikse
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Patent number: 10096456Abstract: A low temperature plasma probe, a mass spectrometry system, and a method for using a low temperature plasma probe are described. In an embodiment, a low temperature plasma probe includes an intake capillary that provides an ion flow from a sample surface to a mass spectrometer; at least one low temperature plasma tube that provides low temperature plasma gas; at least one heated gas tube that provides heated gas to the sample surface, where the heated gas enhances desorption and ionization of a sample on the sample surface.Type: GrantFiled: July 29, 2016Date of Patent: October 9, 2018Assignee: SMITHS DETECTION INC.Inventors: Vadym Berkout, Thomas D. Saul
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Patent number: 9953817Abstract: An ion transfer tube assembly, a mass spectrometry system, and a method for providing an ion stream to an ion detection device are described that include using an ion transfer tube that provides a coaxial sheath gas flow. In an implementation, an ion transfer tube assembly includes an ion transfer tube for delivering the ion stream, where a sheath gas flows through the ion transfer tube, and where the ion transfer tube receives the ion stream from a first conduit coupled to an ion source; a pump fluidly coupled to the ion transfer tube, where the pump causes the sheath gas to flow through the ion transfer tube, where the ion stream is separated from the ion transfer tube walls by the coaxial sheath gas flow, and where the ion stream is received by a second conduit coupled to the ion detection device.Type: GrantFiled: April 22, 2016Date of Patent: April 24, 2018Assignee: Smiths Detection Inc.Inventors: Vadym Berkout, Douglas J. Green
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Publication number: 20180033602Abstract: A low temperature plasma probe, a mass spectrometry system, and a method for using a low temperature plasma probe are described. In an embodiment, a low temperature plasma probe includes an intake capillary that provides an ion flow from a sample surface to a mass spectrometer; at least one low temperature plasma tube that provides low temperature plasma gas; at least one heated gas tube that provides heated gas to the sample surface, where the heated gas enhances desorption and ionization of a sample on the sample surface.Type: ApplicationFiled: July 29, 2016Publication date: February 1, 2018Inventors: Vadym Berkout, Thomas D. Saul
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Patent number: 9842728Abstract: An ion transfer tube assembly, a mass spectrometry system, and a method for providing an ion stream to an ion detection device are described that include using an ion transfer tube and an additional conduit connected to a small high-flow low vacuum pump and a valve. In an implementation, an ion transfer tube assembly includes an ion transfer tube assembly having an intermittent inlet for delivering an ion stream to an ion detection device that employs example techniques in accordance with the present disclosure includes an ion transfer tube, where the ion transfer tube is coupled to a first conduit; a second conduit coupled to the ion transfer tube and the ion detection device; and a third conduit coupled to the second conduit, where the third conduit includes a valve and is coupled to a pump.Type: GrantFiled: June 10, 2016Date of Patent: December 12, 2017Assignee: Smiths DetectionInventor: Vadym Berkout
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Publication number: 20170309461Abstract: An ion transfer tube assembly, a mass spectrometry system, and a method for providing an ion stream to an ion detection device are described that include using an ion transfer tube that provides a coaxial sheath gas flow. In an implementation, an ion transfer tube assembly includes an ion transfer tube for delivering the ion stream, where a sheath gas flows through the ion transfer tube, and where the ion transfer tube receives the ion stream from a first conduit coupled to an ion source; a pump fluidly coupled to the ion transfer tube, where the pump causes the sheath gas to flow through the ion transfer tube, where the ion stream is separated from the ion transfer tube walls by the coaxial sheath gas flow, and where the ion stream is received by a second conduit coupled to the ion detection device.Type: ApplicationFiled: April 22, 2016Publication date: October 26, 2017Inventors: Vadym Berkout, Douglas J. Green
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Patent number: 9679754Abstract: An interface configured to transfer ions produced at or near atmospheric pressure conditions into a mass spectrometer for mass analysis is provided. The interface includes a first conduit including an inlet configured to receive a fluid containing the ions and an outlet configured to direct the fluid containing the ions into the mass spectrometer. The first conduit defines a first flow path extending from the inlet to the outlet. The interface includes a pump. The interface includes a second conduit. The second conduit includes an inlet. The second conduit defines a second flow path extending from a location between the inlet and the outlet of the first conduit to an outlet of the second conduit. The pump is configured to divert a portion of the fluid including the ions moving in the first flow path to the second flow path.Type: GrantFiled: July 7, 2014Date of Patent: June 13, 2017Assignee: Smiths Detection Inc.Inventor: Vadym Berkout
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Patent number: 9564305Abstract: A sample inlet device and methods for use of the sample inlet device are described that include an ion funnel having a plurality of electrodes with apertures arranged about an axis extending from an inlet of the ion funnel to an outlet of the ion funnel, the ion funnel including a plurality of spacer elements disposed coaxially with the plurality of electrodes, each of the plurality of spacer elements being positioned between one or two adjacent electrodes, each of the plurality of spacer elements having an aperture with a diameter that is greater than a diameter of each adjacent electrode. The ion funnel is configured to pass an ion sample through the apertures of the electrodes and the spacer elements to additional portions of a detection system, such as to a mass analyzer system and detector.Type: GrantFiled: July 29, 2014Date of Patent: February 7, 2017Assignee: Smiths Detection Inc.Inventors: Vadym Berkout, Jan Hendrikse
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Publication number: 20160293392Abstract: An ion transfer tube assembly, a mass spectrometry system, and a method for providing an ion stream to an ion detection device are described that include using an ion transfer tube and an additional conduit connected to a small high-flow low vacuum pump and a valve. In an implementation, an ion transfer tube assembly includes an ion transfer tube assembly having an intermittent inlet for delivering an ion stream to an ion detection device that employs example techniques in accordance with the present disclosure includes an ion transfer tube, where the ion transfer tube is coupled to a first conduit; a second conduit coupled to the ion transfer tube and the ion detection device; and a third conduit coupled to the second conduit, where the third conduit includes a valve and is coupled to a pump.Type: ApplicationFiled: June 10, 2016Publication date: October 6, 2016Inventor: Vadym Berkout
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Publication number: 20160181079Abstract: An interface configured to transfer ions produced at or near atmospheric pressure conditions into a mass spectrometer for mass analysis is provided. The interface includes a first conduit including an inlet configured to receive a fluid containing the ions and an outlet configured to direct the fluid containing the ions into the mass spectrometer. The first conduit defines a first flow path extending from the inlet to the outlet. The interface includes a pump. The interface includes a second conduit. The second conduit includes an inlet. The second conduit defines a second flow path extending from a location between the inlet and the outlet of the first conduit to an outlet of the second conduit. The pump is configured to divert a portion of the fluid including the ions moving in the first flow path to the second flow path.Type: ApplicationFiled: July 7, 2014Publication date: June 23, 2016Inventor: Vadym Berkout
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Publication number: 20160172177Abstract: An intermittent sample inlet device and methods for use of the intermittent sample inlet device are described that include an orifice plate with an entrance orifice and a rotating skimmer with a skimmer orifice, where the rotating skimmer is disposed between the orifice plate and a vacuum chamber wall. The rotating skimmer rotates so that the skimmer orifice intermittently aligns with the entrance orifice and allows an ion sample to pass through to a mass analyzer.Type: ApplicationFiled: July 31, 2014Publication date: June 16, 2016Inventor: Vadym BERKOUT
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Publication number: 20160035556Abstract: A sample inlet device and methods for use of the sample inlet device are described that include an ion funnel having a plurality of electrodes with apertures arranged about an axis extending from an inlet of the ion funnel to an outlet of the ion funnel, the ion funnel including a plurality of spacer elements disposed coaxially with the plurality of electrodes, each of the plurality of spacer elements being positioned between one or two adjacent electrodes, each of the plurality of spacer elements having an aperture with a diameter that is greater than a diameter of each adjacent electrode. The ion funnel is configured to pass an ion sample through the apertures of the electrodes and the spacer elements to additional portions of a detection system, such as to a mass analyzer system and detector.Type: ApplicationFiled: July 29, 2014Publication date: February 4, 2016Inventors: Vadym Berkout, Jan Hendrikse
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Publication number: 20070114384Abstract: An apparatus for mass analyzing molecules includes a mass spectrometer configured to select precursor ions having a mass to charge ratio range, a metastable species generator configured to generate a metastable species for introduction into the mass spectrometer, and a mass detector configured to detect a mass of the product ions. The apparatus also includes interaction region in the mass spectrometer where the precursor ions are converted into product ions via interaction of the precursor ions with the metastable species. The mass spectrometer includes at least one of a three-dimensional ion trap, a linear ion trap, or an ion guide. The interaction region is located inside the three-dimensional ion trap, the linear trap, or the ion guide; and at least one of the precursor ions or at least one of the product ions are excited by an alternating electric field or collisionally activated to produce additional product ions.Type: ApplicationFiled: January 5, 2007Publication date: May 24, 2007Applicant: Science & Engineering Services, Inc.Inventors: Vadym Berkout, Vladimir Doroshenko
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Publication number: 20060273254Abstract: An apparatus for analyzing a sample material includes a desorption mechanism configured to desorb molecules from the sample material, a metastable generator separate from the desorption mechanism and configured to generate a metastable species, and an interaction region configured for metastable species ionization of the desorbed molecules so as to produce gas-phase ions of the sample material.Type: ApplicationFiled: June 6, 2005Publication date: December 7, 2006Applicant: Science & Engineering Services, Inc.Inventors: Vadym Berkout, Vladimir Doroshenko