Patents by Inventor Valdas Jurkauskas
Valdas Jurkauskas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230286918Abstract: Disclosed herein are methods and processes of preparing vadadustat or a pharmaceutically acceptable salts thereof, and intermediates (e.g., a compound of Formula (I), (I-F), (II), or (IV), or a pharmaceutically acceptable salts thereof) useful for the synthesis of vadadustat.Type: ApplicationFiled: July 1, 2021Publication date: September 14, 2023Applicant: Akebia Therapeutics, Inc.Inventors: Valdas JURKAUSKAS, Young Chun JUNG, Taesoo KWON, Arunachalam KANNAN, Vijaya Bhasker GONDI
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Publication number: 20210401798Abstract: The invention relates to (S)-6-((1 R,2E,4E,8E,10S)-11-(4-fluorophenoxy)-1,10-dihydroxyundeca-2,4,8-trien-6-yn-1-yl)-1,4-dioxan-2-one (compound (1)), which is a lactone-containing analog of lipoxin A4 (LXA4). In particular, the invention features pharmaceutical compositions including compound (1) and the use of compound (1) for the treatment of a disorder (e.g., a fibrotic disorder or an inflammatory disorder, such as an autoimmune disorder) in a subject in need thereof.Type: ApplicationFiled: October 23, 2019Publication date: December 30, 2021Applicants: The Brigham and Women's Hospital, Inc., Corbus Pharmaceuticals, Inc., Corbus Pharmaceuticals, Inc.Inventors: Nan CHIANG, Sheldon N. CRANE, Thomas JENNEQUIN, Valdas JURKAUSKAS, Clifton D. LEIGH, Kristos Adrian MOSHOS, Charles N. Serhan, Mark A. Tepper, Yuhua George Zhang
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Publication number: 20210198223Abstract: The invention provides methods and compositions relating to an ultrapure formulation of 5-(1,1-dimethylheptyl)-resorcinol (ultrapure DMHR). The invention features methods for making ultrapure DMHR, including methods that minimize the production of unwanted side products (e.g., the production of homologous alkyl-chain impurities). The invention also features methods of making cannabinoids, such as (6aR,10aR)-1-hydroxy-6,6-dimethyl-3-(2-methyl-2-octanyl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromene-9-carboxylic acid (ajulemic acid), using ultrapure DMHR, including methods that minimize the production of unwanted side products (e.g., the production of homologous alkyl-chain impurities) in the resulting cannabinoid preparation.Type: ApplicationFiled: October 19, 2018Publication date: July 1, 2021Inventors: Valdas JURKAUSKAS, Kristos Adrian MOSHOS, Clifton D. LEIGH, Feng SHI, Xiaofeng CHEN, Chengfu XIE
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Patent number: 10941161Abstract: Described herein are crystalline forms of a compound of formula (III?), including toluene solvates of TATD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane.Type: GrantFiled: March 4, 2019Date of Patent: March 9, 2021Assignee: Merck Sharp & Dohme Corp.Inventors: Kristos Adrian Moshos, Valdas Jurkauskas, Giovanni Fogliato, Manuel Scanu, You Seok Hwang
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Publication number: 20190225624Abstract: Described herein are crystalline forms of a compound of formula (III?), including toluene solvates of TATD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane.Type: ApplicationFiled: March 4, 2019Publication date: July 25, 2019Applicant: Merck Sharp & Dohme Corp.Inventors: Kristos Adrian Moshos, Valdas Jurkauskas, Giovanni Fogliato, Manuel Scanu, You Seok Hwang
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Patent number: 10308666Abstract: This disclosure provides methods of making certain 7-aminocephem derivatives useful in the manufacture of cephalosporin antibiotic compounds.Type: GrantFiled: March 14, 2018Date of Patent: June 4, 2019Assignee: Merck Sharp & Dohme Corp.Inventors: Kristos Adrian Moshos, Valdas Jurkauskas
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Patent number: 10221196Abstract: Described herein are crystalline forms of a compound of formula (II?), including toluene solvates off A TD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane. Provided herein is a crystalline form of a compound of formula (II?): wherein X is CI, Br, or I; and R1 and R2 are each independently an oxygen protecting group; processes for making the crystalline form, and use of said form in the synthesis of antibacterial cephalosporins such as ceftolozane.Type: GrantFiled: August 14, 2015Date of Patent: March 5, 2019Assignee: Merck Sharp & Dohme Corp.Inventors: Kristos Adrian Moshos, Valdas Jurkauskas, Giovanni Fogliato, Manuel Scanu, You Seok Hwang
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Patent number: 10214543Abstract: Described herein are methods for the manufacture of ceftolozane and related compounds, as well as compositions comprising the same.Type: GrantFiled: December 18, 2015Date of Patent: February 26, 2019Assignee: Merck Sharp & Dohme Corp.Inventors: Kristos Adrian Moshos, Valdas Jurkauskas, Giovanni Fogliato, Manuel Scanu, Michele Benotti
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Publication number: 20180258101Abstract: This disclosure provides methods of making certain 7-aminocephem derivatives useful in the manufacture of cephalosporin antibiotic compounds.Type: ApplicationFiled: March 14, 2018Publication date: September 13, 2018Applicant: Merck Sharp & Dohme Corp.Inventors: Kristos Adrian MOSHOS, Valdas JURKAUSKAS
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Patent number: 10059680Abstract: Thiadiazolyl-oximinoacetic acid derivatives have been synthesized, which are useful in the manufacture of cephalosporin antibiotic compounds. Compound (1) (TATD) is commercially available (CAS No. 76028-96-1). It has now been discovered that the thiadiazolyl-oximinoacetic acid derivative compound (1) (TATD) can be prepared from dimethyl malonate (SM 1, CAS No. 108-59-8) according to methods described herein. The methods provide products having desirable purity.Type: GrantFiled: December 18, 2015Date of Patent: August 28, 2018Assignee: Merck Sharp & Dohme Corp.Inventors: Kristos Adrian Moshos, Valdas Jurkauskas
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Patent number: 10035774Abstract: Pyrazolyl carboxylic acid and pyrazolyl urea derivatives have been synthesized, which are useful in the manufacture of cephalosporin antibiotic compounds.Type: GrantFiled: December 18, 2015Date of Patent: July 31, 2018Assignee: Merck Sharp & Dohme Corp.Inventors: Kristos Adrian Moshos, Valdas Jurkauskas, Yisheng Yang, Youchu Wang
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Publication number: 20180170949Abstract: Described herein are methods for the manufacture of ceftolozane and related compounds, as well as compositions comprising the same.Type: ApplicationFiled: December 18, 2015Publication date: June 21, 2018Applicant: MERCK SHARP & DOHME CORP.Inventors: Kristos Adrian MOSHOS, Valdas JURKAUSKAS, Giovanni FOGLIATO, Manuel SCANU, Michele BENOTTI
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Patent number: 10000510Abstract: This disclosure relates to salt forms of ceftolozane, processes for making these salt forms, and compositions comprising the same. Also disclosed are stabilized compositions of ceftolozane. Provided herein are salt forms of ceftolozane, processes for making these salt forms and compositions comprising the same. The salt forms provided herein include ceftolozane bromide, ceftolozane edisylate, ceftolozane mesylate, ceftolozane chloride, ceftolozane sulfate, ceftolozane maleate, ceftolozane phosphate, and ceftolozane ketoglutarate.Type: GrantFiled: August 17, 2015Date of Patent: June 19, 2018Assignee: MERCK SHARP & DOHME CORP.Inventors: Jian-Qiao Gu, Valdas Jurkauskas, Carlos Lopez, Kristos Adrian Moshos, Pradip M. Pathare, Sudhakar Garad, You Seok Hwang
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Publication number: 20170369459Abstract: Thiadiazolyl-oximinoacetic acid derivatives have been synthesized, which are useful in the manufacture of cephalosporin antibiotic compounds. Compound (1) (TATD) is commercially available (CAS No. 76028-96-1). It has now been discovered that the thiadiazolyl-oximinoacetic acid derivative compound (1) (TATD) can be prepared from dimethyl malonate (SM 1, CAS No. 108-59-8) according to methods described herein. The methods provide products having desirable purity.Type: ApplicationFiled: December 18, 2015Publication date: December 28, 2017Applicant: Merck Sharp & Dohme CorplInventors: Kristos Adrian Moshos, Valdas Jurkauskas
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Publication number: 20170362183Abstract: Pyrazolyl carboxylic acid and pyrazolyl urea derivatives have been synthesized, which are useful in the manufacture of cephalosporin antibiotic compounds.Type: ApplicationFiled: December 18, 2015Publication date: December 21, 2017Applicant: Merck Sharp & Dohme Corp.Inventors: Kristos Adrian Moshos, Valdas Jurkauskas, Yisheng Yang, Youchu Wang
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Patent number: 9771361Abstract: Polymorphic forms of Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula: are Form A of HCl salt of Compound (1).½H2O, Form F of HCl salt of Compound (1).3H2O, Form D of HCl salt of Compound (1), Form A of Compound (1), and Form A of tosylate salt of Compound (1). Such polymorphic forms are employed for treating influenza, inhibiting the replication of influenza viruses, or reducing the amount of influenza viruses in a biological sample or in a subject.Type: GrantFiled: May 10, 2016Date of Patent: September 26, 2017Assignee: Vertex Pharmaceuticals IncorporatedInventors: Kwame W. Nti-Addae, Michael Waldo, Simon Adam O'Neil, John Gregg Van Alsten, Dainius Macikenas, Praveen Mudunuri, Yi Shi, Mark Willem Ledeboer, Valdas Jurkauskas, Ales Medek, Steven Jones, Randal Byrn, Mohammed Asmal, Sarah Marie Robertson, Wanjung Tsai
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Publication number: 20170233408Abstract: This disclosure relates to salt forms of ceftolozane, processes for making these salt forms, and compositions comprising the same. Also disclosed are stabilized compositions of ceftolozane. Provided herein are salt forms of ceftolozane, processes for making these salt forms and compositions comprising the same. The salt forms provided herein include ceftolozane bromide, ceftolozane edisylate, ceftolozane mesylate, ceftolozane chloride, ceftolozane sulfate, ceftolozane maleate, ceftolozane phosphate, and ceftolozane ketoglutarate.Type: ApplicationFiled: August 17, 2015Publication date: August 17, 2017Applicant: Merck Sharp & Dohme Corp.Inventors: Jian-Qiao Gu, Valdas Jurkauskas, Carlos Lopez, Kristos Adrian Moshos, Pradip M. Pathare, Sudhakar Garad, You Seok Hwang
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Publication number: 20170226126Abstract: Described herein are crystalline forms of a compound of formula (III?), including toluene solvates off A TD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane. Provided herein is a crystalline form of a compound of formula (III?): wherein X is CI, Br, or I; and R1 and R2 are each independently an oxygen protecting group; processes for making the crystalline form, and use of said form in the synthesis of antibacterial cephalosporins such as ceftolozane.Type: ApplicationFiled: August 14, 2015Publication date: August 10, 2017Applicant: Merck Sharp & Dohme Corp.Inventors: Kristos Adrian Moshos, Valdas Jurkauskas, Giovanni Fogliato, Manuel Scanu, You Seok Hwang
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Patent number: 9695196Abstract: This disclosure relates to an improved synthesis of cephalosporin antibiotic compounds such as ceftolozane, and compositions and methods of use thereof. Thiadiazolyl-oximinoacetic acid compounds such as TATD can be reacted to yield the activated thiadiazolyl-oximinoacetic acid methanesulfonate ester compounds useful in the manufacture of cephalosporin antibiotic compounds.Type: GrantFiled: June 19, 2015Date of Patent: July 4, 2017Assignee: Merck Sharp & Dohme Corp.Inventors: Kristos Adrian Moshos, Valdas Jurkauskas, Manuel Scanu, Michele Benotti
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Publication number: 20160251353Abstract: Polymorphic forms of Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula: are Form A of HCl salt of Compound (1).½H2O, Form F of HCl salt of Compound (1).3H2O, Form D of HCl salt of Compound (1), Form A of Compound (1), and Form A of tosylate salt of Compound (1). Such polymorphic forms are employed for treating influenza, inhibiting the replication of influenza viruses, or reducing the amount of influenza viruses in a biological sample or in a subject.Type: ApplicationFiled: May 10, 2016Publication date: September 1, 2016Inventors: Kwame W. Nti-Addae, Michael Waldo, Simon Adam O'Neil, John Gregg Van Alsten, Dainius Macikenas, Praveen Mudunuri, Yi Shi, Mark Willem Ledeboer, Valdas Jurkauskas, Ales Medek, Steven Jones, Randal Byrn, Mohammed Asmal, Sarah Marie Robertson, Wanjung Tsai