Patents by Inventor Valentina Riveros-Rojas

Valentina Riveros-Rojas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for stabilizing immunoglobulin compositions
    Patent number: 5792838
    Abstract: The invention relates to a stabilised immunoglobulin composition comprising at least one immunoglobulin together with a stabilising amount of a chelator of copper ions such as EDTA or citrate. Preferably the immunoglobulin is an antibody, for example a recombinant CDR-grafted antibody against the CDw52 antigen, most preferably CAMPATH-1H. The invention also relates to a process for enhancing the stability of an immunoglobulin which comprises subjecting the immunoglobulin to a purification procedure capable of removing copper ions therefrom. Preferably the immunoglobulin is rendered substantially free from detectable copper ions, for example on atomic absorption spectroscopy.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: August 11, 1998
    Assignee: Glaxo Wellcome Inc.
    Inventors: Marjorie Smith, Valentina Riveros-Rojas
  • Immunoglobulins stabilized with a chelator of copper ions
    Patent number: 5654403
    Abstract: A stabilized immunoglobulin composition comprises at least one immunoglobulin together with a stabilizing amount of a chelator of copper ions such as EDTA or citrate. Preferably the immunoglobulin is an antibody, for example, a recombinant CDR-grafted antibody. A process for enhancing the stability of an immunoglobulin comprises subjecting the immunoglobulin to a purification procedure capable of removing copper ions therefrom. Preferably, the immunoglobulin is rendered substantially free from detectable copper ions as determined, for example, by atomic absorption spectroscopy.
    Type: Grant
    Filed: April 28, 1994
    Date of Patent: August 5, 1997
    Assignee: Burroughs Wellcome Co.
    Inventors: Marjorie Smith, Valentina Riveros-Rojas