Patents by Inventor Valentine V. Shick

Valentine V. Shick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Rapid method to detect duplex formation in sequencing by hybridization methods, a method for constructing containment structures for reagent interaction
    Patent number: 6465174
    Abstract: A method for determining the existence of duplexes of oligonucleotide complementary molecules is provided whereby a plurality of immobilized oligonucleotide molecules, each of a specific length and each having a specific base sequence, is contacted with complementary, single stranded oligonucleotide molecules to form a duplex so as to facilitate intercalation of a fluorescent dye between the base planes of the duplex. The invention also provides for a method for constructing oligonucleotide matrices comprising confining light sensitive fluid to a surface, exposing said light-sensitive fluid to a light pattern so as to cause the fluid exposed to the light to polymerize into discrete units and adhere to the surface; and contacting each of the units with a set of different oligonucleotide molecules so as to allow the molecules to disperse into the units.
    Type: Grant
    Filed: July 31, 1998
    Date of Patent: October 15, 2002
    Assignee: University of Chicago
    Inventors: Andrei Darievich Mirzabekov, Gennadiy Moiseyevich Yershov, Dmitry Yuryevich Guschin, Margaret Anne Gemmell, Valentine V. Shick, Dmitri Y. Proudnikov, Edward N. Timofeev
  • Methods for immobilizing nucleic acids on a gel substrate
    Patent number: 5981734
    Abstract: A method for labeling oligonucleotide molecules, and for immobilizing oligonucleotide and DNA molecules is provided comprising modifying the molecules to create a chemically active group, and contacting activated fluorescent dyes to the region. A method for preparing an immobilization substrate is also provided comprising modifying a gel to contain desired functional groups which covalently interact with certain moieties of the oligonucleotide molecules. A method for immobilizing biomolecules and other molecules within a gel by copolymerization of allyl-substituted oligonucleotides, DNA and proteins with acrylamide is also provided.
    Type: Grant
    Filed: July 17, 1997
    Date of Patent: November 9, 1999
    Assignee: University of Chicago
    Inventors: Andrei Darievich Mirzabekov, Dimitri Y. Proudnikov, Edward N. Timofeev, Svetlana V. Kochetkova, Vladimir L. Florentiev, Valentine V. Shick