Patents by Inventor Valerie Liu Tsang

Valerie Liu Tsang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Control of protein glycosylation by culture medium supplementation and cell culture process parameters
    Patent number: 10676772
    Abstract: The present invention pertains to a cell culture medium comprising media supplements that are shown to control recombinant protein glycosylation and/or cell culture in a controlled or modulated (shifted) temperature to control recombinant protein glycosylation and/or cell culture with controlled or modulated seed density to control recombinant protein glycosylation, and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.
    Type: Grant
    Filed: April 16, 2018
    Date of Patent: June 9, 2020
    Assignees: Biogen MA Inc., Samsung Bioepis
    Inventors: William C. Yang, Yao-Ming Huang, Kyle McElearney, Lia Tescione, James Lambropoulos, An Zhang, Valerie Liu Tsang, Thomas Ryll, Sangil Lee, Dae Sung Lee
  • CONTROL OF PROTEIN GLYCOSYLATION BY CULTURE MEDIUM SUPPLEMENTATION AND CELL CULTURE PROCESS PARAMETERS
    Publication number: 20190085369
    Abstract: The present invention pertains to a cell culture medium comprising media supplements that are shown to control recombinant protein glycosylation and/or cell culture in a controlled or modulated (shifted) temperature to control recombinant protein glycosylation and/or cell culture with controlled or modulated seed density to control recombinant protein glycosylation, and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.
    Type: Application
    Filed: April 16, 2018
    Publication date: March 21, 2019
    Applicants: Biogen MA Inc., Samsung Bioepis
    Inventors: William C. Yang, Yao-Ming Huang, Kyle McElearney, Lia Tescione, James Lambropoulos, An Zhang, Valerie Liu Tsang, Thomas Ryll, Sangil Lee, Dae Sung Lee
  • Nutrient monitoring and feedback control for increased bioproduct production
    Patent number: 9212379
    Abstract: The present invention pertains to methods of increasing the efficiency of producing a bioproduct. In some embodiments, the method increases the quantity of a bioproduct produced, or decreases bioproduct production time, in a bioreactor cell culture producing the bioproduct, the method comprising, (a) intermittently or continuously analyzing the concentration of one or more nutrients in the bioreactor cell culture; and (b) adding to the bioreactor cell culture additional nutrient media when the concentration of the one or more nutrients is lower than a target value.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: December 15, 2015
    Assignee: Biogen Idec MA Inc.
    Inventors: Valerie Liu Tsang, Angela Xiaoying Wang, Helena Yusuf-Makagiansar
  • Three dimensional cell patterned biopolymer scaffolds and methods of making the same
    Patent number: 8906684
    Abstract: Provided are methods of the production of patterned 3-dimensional biopolymer scaffolds containing living cells. The methods include selective photopolymerization of biopolymers to create patterned structures and the patterning of cells within relatively homogenous slabs of biopolymer using dielectrophoresis. Also provided are patterned 3-dimensional biopolymer scaffolds generated by the methods and their use.
    Type: Grant
    Filed: January 12, 2005
    Date of Patent: December 9, 2014
    Assignee: The Regents of the University of California
    Inventors: Sangeeta N. Bhatia, Valerie Liu Tsang, Dirk R. Albrecht
  • Nutrient monitoring and feedback control for increased bioproduct production
    Patent number: 8318416
    Abstract: The present invention pertains to methods of increasing the efficiency of producing a bioproduct. In some embodiments, the method increases the quantity of a bioproduct produced, or decreases bioproduct production time, in a bioreactor cell culture producing the bioproduct, the method comprising, (a) intermittently or continuously analyzing the concentration of one or more nutrients in the bioreactor cell culture; and (b) adding to the bioreactor cell culture additional nutrient media when the concentration of the one or more nutrients is lower than a target value.
    Type: Grant
    Filed: August 7, 2009
    Date of Patent: November 27, 2012
    Assignee: Biogen Idec MA Inc.
    Inventors: Valerie Liu Tsang, Angela Xiaoying Wang, Helena Yusuf-Makagiansar
  • Nutrient Monitoring and Feedback Control for Increased Bioproduct Production
    Publication number: 20100068693
    Abstract: The present invention pertains to methods of increasing the efficiency of producing a bioproduct. In some embodiments, the method increases the quantity of a bioproduct produced, or decreases bioproduct production time, in a bioreactor cell culture producing the bioproduct, the method comprising, (a) intermittently or continuously analyzing the concentration of one or more nutrients in the bioreactor cell culture; and (b) adding to the bioreactor cell culture additional nutrient media when the concentration of the one or more nutrients is lower than a target value.
    Type: Application
    Filed: August 7, 2009
    Publication date: March 18, 2010
    Inventors: Valerie Liu TSANG, Angela Xiaoying WANG, Helena YUSUF-MAKAGIANSAR