Patents by Inventor Valeriya N. Smolenskaya

Valeriya N. Smolenskaya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Solid forms of a toll-like receptor modulator
    Patent number: 11773098
    Abstract: The present invention provides crystalline forms, solvates and hydrates of 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one, and methods of making.
    Type: Grant
    Filed: June 21, 2021
    Date of Patent: October 3, 2023
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Krista Marie Diaz, Patricia Andres, Valeriya N. Smolenskaya
  • SOLID FORMS OF A TOLL-LIKE RECEPTOR MODULATOR
    Publication number: 20220009928
    Abstract: The present invention provides crystalline forms, solvates and hydrates of 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one, and methods of making.
    Type: Application
    Filed: June 21, 2021
    Publication date: January 13, 2022
    Inventors: Krista Marie Diaz, Patricia Andres, Valeriya N. Smolenskaya
  • Solid forms of an ASK1 inhibitor
    Patent number: 10946004
    Abstract: Crystalline forms of 5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: March 16, 2021
    Assignee: Gilead Sciences, Inc.
    Inventors: Mark Andres, Brenda J. Burke Chan, Ernest A. Carra, Anna Chiu, Olga Viktorovna Lapina, Stephen P. Lathrop, Gregory Notte, Valeriya N. Smolenskaya, Lok Him Yu
  • Solid forms of a toll-like receptor modulator
    Patent number: 10508117
    Abstract: The present invention provides crystalline forms, solvates and hydrates of 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one, and methods of making.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: December 17, 2019
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Patricia Andres, Krista Marie Diaz, Valeriya N. Smolenskaya
  • SOLID FORMS OF A TOLL-LIKE RECEPTOR MODULATOR
    Publication number: 20190315750
    Abstract: The present invention provides crystalline forms, solvates and hydrates of 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one, and methods of making.
    Type: Application
    Filed: December 21, 2018
    Publication date: October 17, 2019
    Inventors: Patricia Andres, Krista Marie Diaz, Valeriya N. Smolenskaya
  • Crystal forms of (R)-N-methylnaltrexone bromide and uses thereof
    Patent number: 9879024
    Abstract: The present invention provides a new forms of (R)-N-methylnaltrexone, and compositions thereof, useful as a peripheral mu opioid receptor antagonist.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: January 30, 2018
    Assignees: Progenics Pharmaceuticals., Inc., Wyeth, LLC
    Inventors: Valeriya N. Smolenskaya, Kadum A. Al Shareffi, Julio Perez, Syed M. Shah, Thomas A. Boyd
  • Solid forms comprising N-(5-tert-butyl-isoxazol-3-yl)-N?-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions thereof, and uses therewith
    Patent number: 9585892
    Abstract: Solid forms comprising N-(5-tert-butyl-isoxazol-3-yl)-N?-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions comprising the solid forms, methods of making the solid forms and methods of their use for the treatment of various diseases and/or disorders are disclosed.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: March 7, 2017
    Assignee: Ambit Biosciences
    Inventors: Shripad S. Bhagwat, Wei Lai, Stephan D. Parent, Melanie J. Bevill, Alan Schwartz, Valeriya N. Smolenskaya
  • CRYSTAL FORMS OF (R)-N-METHYLNALTREXONE BROMIDE AND USES THEREOF
    Publication number: 20160068540
    Abstract: The present invention provides a new forms of (R)—N-methylnaltrexone, and compositions thereof, useful as a peripheral mu opioid receptor antagonist.
    Type: Application
    Filed: August 7, 2015
    Publication date: March 10, 2016
    Inventors: Valeriya N. Smolenskaya, Kadum A. Al Shareffi, Julio Perez, Syed M. Shah, Thomas A. Boyd
  • SOLID FORMS COMPRISING N-(5-TERT-BUTYL-ISOXAZOL-3-YL)-N'-UREA, COMPOSITIONS THEREOF, AND USES THEREWITH
    Publication number: 20150238499
    Abstract: Solid forms comprising N-(5-tert-butyl-isoxazol-3-yl)-N?-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions comprising the solid forms, methods of making the solid forms and methods of their use for the treatment of various diseases and/or disorders are disclosed.
    Type: Application
    Filed: October 7, 2014
    Publication date: August 27, 2015
    Inventors: Shripad S. Bhagwat, Wei Lai, Stephan D. Parent, Melanie J. Roe, Alan Schwartz, Valeriya N. Smolenskaya
  • Crystal forms of (R)-N-methylnaltrexone bromide and uses thereof
    Patent number: 9102680
    Abstract: The present invention provides a new forms of (R)—N-methylnaltrexone, and compositions thereof, useful as a peripheral mu opioid receptor antagonist.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: August 11, 2015
    Assignees: Wyeth LLC, Progenics Pharmamceuticals, Inc.
    Inventors: Valeriya N. Smolenskaya, Kadum A. Al Shareffi, Julio Perez, Syed M. Shah, Thomas A. Boyd
  • Solid forms comprising N-(5-tert-butyl-isoxazol-3-yl)-N?-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions thereof, and uses therewith
    Patent number: 8883783
    Abstract: Solid forms comprising N-(5-tert-butyl-isoxazol-3-yl)-N?-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions comprising the solid forms, methods of making the solid forms and methods of their use for the treatment of various diseases and/or disorders are disclosed.
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: November 11, 2014
    Assignee: Ambit Biosciences Corporation
    Inventors: Shripad S. Bhagwat, Wei Lai, Stephan D. Parent, Melanie J. Roe, Alan Schwartz, Valeriya N. Smolenskaya
  • CRYSTAL FORMS OF (R)-N-METHYLNALTREXONE BROMIDE AND USES THEREOF
    Publication number: 20100305323
    Abstract: The present invention provides a new forms of (R)—N-methylnaltrexone, and compositions thereof, useful as a peripheral mu opioid receptor antagonist.
    Type: Application
    Filed: March 28, 2008
    Publication date: December 2, 2010
    Inventors: Valeriya N. Smolenskaya, Kadum A. Al Shareffi, Julio Perez, Syed M. Shah, Thomas A. Boyd
  • SOLID FORMS COMPRISING N-(5-TERT-BUTYL-ISOXAZOL-3-YL)-N'-UREA, COMPOSITIONS THEREOF, AND USES THEREWITH
    Publication number: 20090131426
    Abstract: Solid forms comprising N-(5-tert-butyl-isoxazol-3-yl)-N?-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions comprising the solid forms, methods of making the solid forms and methods of their use for the treatment of various diseases and/or disorders are disclosed.
    Type: Application
    Filed: September 19, 2008
    Publication date: May 21, 2009
    Inventors: Shripad S. Bhagwat, Wei Lai, Stephan D. Parent, Melanie J. Roe, Alan Schwartz, Valeriya N. Smolenskaya