Abstract: A fat tissue observation method includes: a process A of applying an optical clearing agent to fat tissue within a body; a process B of heating the fat tissue to reduce a first refractive index of the fat tissue and put the first refractive index close to a second refractive index of the optical clearing agent; and a process C of observing an inside of the fat tissue that the optical clearing agent permeates.

Abstract: Substances are injected (e.g. laser injected) into skin tissue in order to change optical and/or mechanical properties of the tissue. Methods include ablating one or more micro-holes into tissue, pushing a substance into the one or more micro-holes with energy from the creation of the mirco-holes, with acoustic energy, and/or with laser energy. A container component is filled with the substance to be injected into the skin tissue.

Abstract: The present invention provide methods for treating acne by exposing affected follicles to at least one, and preferably two or all three, of the following radiation pulses: a radiation pulse (PC pulse) having a wavelength components in a range of about 360-700 nm; a radiation pulse (PTV pulse) having wavelength components in a range of about 470 nm to 650 nm and/or in a range of about 500 nm to about 620 nm; and a radiation pulse (PTIR pulse) having wavelength components in a range of about 900 nm to about 1800 nm. The irradiated treatment region is preferably maintained at a temperature of about 38 to 43 C in order to enhance the efficacy of the treatment.

Abstract: A method of modifying or treating biological tissue by microperforating hard tissue is disclosed. The method comprises identifying a target area associated with the hard tissue, using a laser beam to perforate at least one incision in the hard tissue, wherein at least one incision has a diameter from a range of 0.001 mm to 0.5 mm and an aspect ratio from a range of 1 to 100 times, introducing a treatment substance into the incision, and causing the treatment substance to interact with the target area. Also a device for microperforating hard biological tissue is disclosed, comprising a laser pump system and a laser head coupled to the laser pump system for generating a pulsed laser having ranges of wavelengths, a pulse duration, pulse energy from a selected range, a beam divergence factor less than 5, a repetition rate higher than 50 Hz; and a beam delivery system comprised of a focusing system for creating a beam having a diameter from a range of 0.001 mm to 0.5 mm.

Abstract: Oral phototherapy applicators are disclosed that are sized and shaped so as to fit at least partially in a user's mouth and have at least one radiation emitter coupled to an apparatus body to irradiate a portion of the oral cavity with phototherapeutic radiation in at least two separate spectral bands. In one embodiment, the spectral bands are distinct. In another, the bands overlap but provide different therapeutic effects. The apparatus can further include bristles to provide a phototherapeutic toothbrush. Alternatively, the apparatus body can be adapted for placement in a fixed position relative to the oral cavity during phototherapy.

Abstract: Methods and devices for ablating portions of a tissue volume with electromagnetic radiation (EMR) to produce lattices of EMR-treated ablation islets in the tissue are disclosed, including lattices of micro-holes, micro-grooves, and other structures. Also, methods and devices for using the ablated islets are disclosed, including to deliver chromophores, filler, drugs and other substances to the tissue volume.

Abstract: Oral phototherapy applicators are disclosed that are sized and shaped so as to fit at least partially in a user's mouth and have at least one radiation emitter coupled to an apparatus body to irradiate a portion of the oral cavity with phototherapeutic radiation in at least two separate spectral bands. In one embodiment, the spectral bands are distinct. In another, the bands overlap but provide different therapeutic effects. The apparatus can further include bristles to provide a phototherapeutic toothbrush. Alternatively, the apparatus body can be adapted for placement in a fixed position relative to the oral cavity during phototherapy.

Abstract: Methods and devices for ablating portions of a tissue volume with electromagnetic radiation (EMR) to produce lattices of EMR-treated ablation islets in the tissue are disclosed, including lattices of micro-holes, micro-grooves, and other structures. Also, methods and devices for using the ablated islets are disclosed, including to deliver chromophores, filler, drugs and other substances to the tissue volume.

Abstract: Methods and devices for ablating portions of a tissue volume with electromagnetic radiation (EMR) to produce lattices of EMR-treated ablation islets in the tissue are disclosed, including lattices of micro-holes, micro-grooves, and other structures. Also, methods and devices for using the ablated islets are disclosed, including to deliver chromophores, filler, drugs and other substances to the tissue volume.

Abstract: Methods for dental treatment including applying a non-toxic chromophore to a portion of the oral cavity and delivering a low dose of radiation to the chromophore during a session, the radiation having a wavelength in the absorption band of the non-toxic chromophore and the dose being lower than the power density to which the chromophore is normally responsive. Thereafter the step of applying radiation is repeated in subsequent sessions until the chromophore is activated.

Abstract: Oral phototherapy applicators are disclosed that are sized and shaped so as to fit at least partially in a user's mouth and have at least one radiation emitter coupled to an apparatus body to irradiate a portion of the oral cavity with phototherapeutic radiation, the emitter being capable of delivering radiation to a region of facial tissue. The apparatus can be configured to direct radiation to at least one portion of the oral cavity, e.g., a tooth, cheek, tongue, palate, throat, lymphatic tissue, blood, gland, follicle, collagen and pigmentation. In one embodiment, radiation from the emitter can penetrate the muscosal lining of the oral cavity and deliver phototherapeutic energy to a region of facial tissue. The apparatus can further include bristles to provide a phototherapeutic toothbrush. Alternatively, the apparatus body can be adapted for placement in a fixed position relative to the oral cavity during phototherapy.

Abstract: Oral phototherapy applicators are disclosed that sized and shaped so as to fit at least partially in a user's mouth and adapted to conform to the shape of at least a portion of the oral cavity and have at least one radiation emitter coupled to an applicator body to irradiate a portion of the oral cavity with phototherapeutic radiation. The apparatus is configured to direct radiation to at least one portion of the oral cavity, e.g. a tooth, cheek, tongue, palate, throat and facial tissue, lymphatic tissue, blood, gland, follicle, collagen and pigmentation. In one embodiment, the apparatus body is compliant to facilitate conformation to a portion of the oral cavity.

Abstract: Oral phototherapy applicators are disclosed that are sized and shaped so as to fit at least partially in a user's mouth and have at least one radiation emitting element coupled to an apparatus body to irradiate a portion of the oral cavity with phototherapeutic radiation along multiple directions. In one aspect, the apparatus is configured to direct radiation to at least one portion of the oral cavity, such as the teeth, cheeks, tongue, palate, throat, lymphatic tissue, blood, glands, follicles, collagen, pigmentation or facial tissue, generally. The apparatus can further include bristles to provide a phototherapeutic toothbrush. Alternatively, the apparatus body can be adapted for placement in a fixed position relative to the oral cavity during phototherapy.

Abstract: Oral phototherapy applicators are disclosed that are sized and shaped so as to fit at least partially in a user's mouth with a plurality of bristles of elongate shape coupled to an apparatus body. The Applicators can be adapted to brush the user's teeth and further include at least one radiation emitter coupled to the body to provide phototherapeutic radiation to a portion of the oral cavity other than tissue in contact with the bristles. In one embodiment, the phototherapy emitter irradiates both a region of tissue in contact with the bristles and a portion of the oral cavity that is not in contact with the apparatus. For example, the apparatus can include at least one emitter that irradiates tooth tissue in contact with the bristles and gum tissue surrounding the tooth tissue.

Abstract: The present invention provide methods for treating acne by exposing affected follicles to at least one, and preferably two or all three, of the following radiation pulses: a radiation pulse (PC pulse) having a wavelgnth components in a range of about 360-700 nm; a radiation pulse (PTV pulse) having wavelength components in a range of about 470 nm to 650 nm and/or in a range of about 500 nm to about 620 nm; and a radiation pulse (PTIR pulse) having wavelength components in a range of about 900 nm to about 1800 nm. The irradiated treatment region is preferably maintained at a temperature of about 38 to 43 C in order to enhance the efficacy of the treatment.

Abstract: Oral phototherapy applicators are disclosed that are sized and shaped so as to fit at least partially in a user's mouth and have at least one radiation emitter coupled to an apparatus body to irradiate a portion of the oral cavity with phototherapeutic radiation in at least two separate spectral bands. In one embodiment, the spectral bands are distinct. In another, the bands overlap but provide different therapeutic effects. The apparatus can further include bristles to provide a phototherapeutic toothbrush. Alternatively, the apparatus body can be adapted for placement in a fixed position relative to the oral cavity during phototherapy.

Abstract: Oral phototherapy applicators are disclosed that sized and shaped so as to fit at least partially in a user's mouth and adapted to conform to the shape of at least a portion of the oral cavity and have at least one radiation emitter coupled to an applicator body to irradiate a portion of the oral cavity with phototherapeutic radiation. The apparatus is configured to direct radiation to at least one portion of the oral cavity, e.g. a tooth, cheek, tongue, palate, throat and facial tissue, lymphatic tissue, blood, gland, follicle, collagen and pigmentation.

Abstract: Methods and apparatus for irradiating at least a portion of a subject's oral cavity with radiation having at least one selected wavelength component so as to cause a desired biostimulation effect.

Abstract: Oral phototherapy applicators are disclosed that are sized and shaped so as to fit at least partially in a user's mouth with a plurality of bristles of elongate shape coupled to an apparatus body. The Applicators can be adapted to brush the user's teeth and further include at least one radiation emitter coupled to the body to provide phototherapeutic radiation to a portion of the oral cavity other than tissue in contact with the bristles. In one embodiment, the phototherapy emitter irradiates both a region of tissue in contact with the bristles and a portion of the oral cavity that is not in contact with the apparatus. For example, the apparatus can include at least one emitter that irradiates tooth tissue in contact with the bristles and gum tissue surrounding the tooth tissue.

Abstract: Methods for dental treatment including applying a non-toxic chromophore to a portion of the oral cavity and delivering a low dose of radiation to the chromophore during a session, the radiation having a wavelength in the absorption band of the non-toxic chromophore and the dose being lower than the power density to which the chromophore is normally responsive. Thereafter the step of applying radiation is repeated in subsequent sessions until the chromophore is activated.