Patents by Inventor Vassil S. Georgiev

Vassil S. Georgiev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5-substituted-3-phenyl-3-[1H-imidazol-1-ylmethyl) or (1H-1,2,4-triazol-1-ylmethyl]-2-benzylisoxazolidines (ir 3011)
    Patent number: 4749793
    Abstract: 5-Substituted-3-phenyl-3-[1H-imidazol-1-ylmethyl) or (1H-1,2,4-triazol-1-ylmethyl)]-2-benzylisoxazolidines are useful as antifungal agents.
    Type: Grant
    Filed: October 2, 1987
    Date of Patent: June 7, 1988
    Assignee: Pennwalt Corporation
    Inventors: Vassil S. Georgiev, George B. Mullen
  • Substituted alpha-[2'-tricyclo[3.3.1.1.sup.3,7 ]-decylidene]benzeneacetonitrile derivatives
    Patent number: 4748264
    Abstract: Substituted .alpha.-[2'-tricyclo[3.3.1.1.sup.3,7 ]decylidene]benzeneacetonitrile derivatives having antihypoxia and anti-inflammatory activities of the formula: ##STR1## where the R.sup.1, R.sup.2 and R.sup.3 substituents are independently selected from hydrogen, lower alkyl, lower alkoxy, halogen and trifluoromethane, provided that at least one of such substituents is hydrogen.
    Type: Grant
    Filed: May 27, 1986
    Date of Patent: May 31, 1988
    Assignee: Pennwalt Corporation
    Inventors: Vassil S. Georgiev, George B. Mullen
  • Substituted alpha-(2-tricyclo(3.3.1.13,7)-decylidene)benzeneacetamide derivatives
    Patent number: 4745220
    Abstract: Substituted .alpha.-[2'-tricyclo[3.3.1.1.sup.3,7 ]decylidene]-benzenacetamide derivatives of the formula: ##STR1## where the R.sup.1, R.sup.2 and R.sup.3 substitutents are independently selected from hydrogen, lower alkyl, lower alkoxy, halogen and trifluoromethyl, provided that at least one of such substitutents is hydrogen, have antihypoxia, antiparkinson, and/or anticonvulsant activities.
    Type: Grant
    Filed: May 27, 1986
    Date of Patent: May 17, 1988
    Assignee: Pennwalt Corporation
    Inventors: Vassil S. Georgiev, George B. Mullen
  • Method of suppressing the immune system comprising administering 5H-thiazolo[2,3-b]quinazoline-3(2H)-one
    Patent number: 4738964
    Abstract: The novel compound, 5H-thiazolo[2,3-b]quinazolin-3(2H)-one, and derivatives thereof in which a nuclear hydrogen of its benzene ring is replaced by lower alkyl, alkoxy, halogen, trifluoromethyl, NO.sub.2 or NH.sub.2 ; useful as anti-hypertensive agents and immunosuppressive agents.
    Type: Grant
    Filed: July 3, 1986
    Date of Patent: April 19, 1988
    Assignee: Pennwalt Corporation
    Inventors: Grace A. Saeva, Vassil S. Georgiev
  • Adamantane spiro-pyrrolidine derivatives
    Patent number: 4739074
    Abstract: Adamantane spiro-pyrrolidine derivatives, more specifically, spiro[pyrrolidine-5,2'-tricyclo[3.3.1.1.sup.3,7 ]decane]derivatives of the structure ##STR1## where X is oxygen or two hydrogen radicals and R is hydrogen or ##STR2## where R.sup.1 is a C.sub.1 -C.sub.18 alkyl radical, phenyl or phenylcyclopropyl, are disclosed herein. Said derivatives have been found to have activity in laboratory animal models against carrageenan-induced edema.
    Type: Grant
    Filed: January 22, 1986
    Date of Patent: April 19, 1988
    Assignee: Pennwalt Corporation
    Inventors: Vassil S. Georgiev, George B. Mullen
  • 3-(3-halophenyl-3,4-diazatetracyclo-[6.3.1.1.sup.6,10.0.sup.1,5 ]tridec-4-en-2-one compounds and use thereof to treat hypoxia
    Patent number: 4732909
    Abstract: 3-(3-Halophenyl)-3,4-diazatetracyclo-[6.3.1.1.sup.6,10.0.sup.1,5 ]tridec-4-en-2-ones are useful as anti-hypoxia agents.
    Type: Grant
    Filed: June 10, 1987
    Date of Patent: March 22, 1988
    Assignee: Pennwalt Corporation
    Inventors: Vassil S. Georgiev, George B. Mullen, Patricia A. Swift
  • Alkali metal 2,5-dihydro-3-ethoxycarbonyl-2-[(substituted phenyl)amino]-4-furanyloxides
    Patent number: 4730063
    Abstract: Alkali metal 2,5-dihydro-3-ethoxycarbonyl-2-[(substituted phenyl)amino]-4-furanyloxides are useful as anti-allergy agents.
    Type: Grant
    Filed: December 5, 1986
    Date of Patent: March 8, 1988
    Assignee: Pennwalt Corportion
    Inventors: Vassil S. Georgiev, Clyde R. Kinsolving, Robert A. Mack
  • Substituted .alpha.-[2'-tricyclo[3.3.1.1.sup.3,7 ]decylidene]-benzeneacetic acid derivatives
    Patent number: 4705891
    Abstract: Substituted .alpha.-[2'-tricyclo[3.3.1.1.sup.3,7 ]decylidene]-benzeneacetic acid derivatives of the formula: ##STR1## where the R.sup.1, R.sup.2 and R.sup.3 substituents are independently selected from hydrogen, lower alkyl, lower alkoxy, halogen and trifluoromethane, provided that at least one of such substituents is hydrogen have antihypoxia, anticonvulsant and/or antiparkinson activities.
    Type: Grant
    Filed: May 27, 1986
    Date of Patent: November 10, 1987
    Assignee: Pennwalt Corporation
    Inventors: Vassil S. Georgiev, George B. Mullen
  • Adamantane-spirolactams
    Patent number: 4692515
    Abstract: Biologically active substituted spiro[azetidin-2-one-4,2'(or 3,2')adamantanes] of the formula ##STR1## where R is hydrogen, --SO.sub.2 Cl, or alkyl, and one of R.sup.1 and R.sup.2 is an adamantyl group which shares a ring carbon with the lactam group and the other is alkyl, substituted alkyl, phenyl, or substituted phenyl, are disclosed herein.
    Type: Grant
    Filed: June 16, 1986
    Date of Patent: September 8, 1987
    Assignee: Pennwalt Corporation
    Inventors: Vassil S. Georgiev, George B. Mullen
  • Adamantyl phenyl .beta.-alanines
    Patent number: 4691051
    Abstract: Adamantyl phenyl .beta.-alanines having the structure: ##STR1## wherein R is phenyl or substituted phenyl and one of R.sup.1 and R.sup.2 is NH.sub.2 and the other is CO.sub.2 H, are disclosed herein.
    Type: Grant
    Filed: June 4, 1986
    Date of Patent: September 1, 1987
    Assignee: Pennwalt Corporation
    Inventors: Vassil S. Georgiev, George B. Mullen
  • Spiro[isoxazalidine-3,2'-tricyclo[3.3.1.1.sup.3,7 ] decanes]
    Patent number: 4683311
    Abstract: The compounds are of the class of adamantanyl isoxazolidine derivatives useful as anti-inflammatory, antihypoxia, antimicrobial and anticonvulsant agents. Exempliary of a species of the compounds is 2 methyl-5-n-hexyl-spiro[isoxazolidin-3,2'-tricyclo[3.3.1.1.sup.3,7 ] decane].
    Type: Grant
    Filed: January 22, 1986
    Date of Patent: July 28, 1987
    Assignee: Pennwalt Corporation
    Inventors: Vassil S. Georgiev, George B. Mullen
  • 2-adamantanone oxide carbamate derivatives
    Patent number: 4652680
    Abstract: Novel 2-adamantanone oxime carbamate derivatives, including tricyclo[3.3.1.1.sup.3,7 ]decan-2-one O-[(cyclohexyl) aminocarbonyl]oxime, tricyclo[3.3.1.1.sup.3,7 ]decan-2-one O-[3-methoxy)aminocarbonyl] oxime, and tricyclo[3.3.1.1.sup.3,7)decan-2-one O-[(2-chlorophenyl)aminocarbonyl]oxime; useful as antifungal agents against E. floccosum.
    Type: Grant
    Filed: January 28, 1985
    Date of Patent: March 24, 1987
    Assignee: Pennwalt Corporation
    Inventors: Vassil S. Georgiev, Grace A. Saeva
  • 2-(substituted amino)-2-[2-hydroxy-2-alkyl (or phenyl)ethyl]tricyclo[3.3.1.1.sup.3,7 ]decane hydrohalides
    Patent number: 4649222
    Abstract: 2-(Substituted amino)-2-[2-hydroxy-2-alkyl (or phenyl)ethyl]tricyclo[3.3.1.1.sup.3,7 ]decane hydrohalides are described such as 2-(2-hydroxyoctyl)-2-(methylamino)-tricyclo[3.3.1.1.sup.3,7 ]decane hydrochloride. The compounds possess anti-inflammatory, analgesic, anticonvulsant and/or anti-hypoxia activity.
    Type: Grant
    Filed: January 22, 1986
    Date of Patent: March 10, 1987
    Assignee: Pennwalt Corporation
    Inventors: Vassil S. Georgiev, George B. Mullen, Patricia A. Swift
  • 1,4-oxazinone derivatives
    Patent number: 4631340
    Abstract: 1,4-oxazinone derivatives of the structure: ##STR1## wherein one of R and R.sup.1 is hydrogen and the other is --CH.sub.2 CO.sub.2 R.sup.6 (R.sup.6 .dbd.alkyl) or R and R.sup.1 together represent the group .dbd.CHCO.sub.2 R.sup.6, R.sup.2 and R.sup.3 are hydrogen, alkyl, substituted alkyl, phenyl or substituted phenyl or R.sup.2 and R.sup.3 together represent a single adamantyl group, and R.sup.4 and R.sup.5 are hydrogen, alkyl, substituted alkyl, phenyl, substituted phenyl, or benzyl, are disclosed herein.
    Type: Grant
    Filed: October 18, 1985
    Date of Patent: December 23, 1986
    Assignee: Pennwalt Corporation
    Inventors: Vassil S. Georgiev, George B. Mullen
  • N-(phenyl) or N-(phenylcyclopropyl)-2,5-dihydro-2-oxo-4[(substituted phenyl)amino]-3-furancarboxamide derivatives
    Patent number: 4625040
    Abstract: Compounds which possess antiallergy activity have the formula: ##STR1## wherein R is selected from phenyl and phenyl mono or disubstituted with lower alkyl, nitro, halogenated methyl, halogen, lower alkoxy and combinations thereof;wherein R.sup.1 is selected from hydrogen and lower alkyl; andwhere R.sup.2 is selected from phenyl, phenyl monosubstituted with lower alkyl, nitro, halogenated methyl, halogen, and lower alkoxy, and trans-phenylcyclopropyl in which the phenyl group may be substituted with lower alkyl or halogen.
    Type: Grant
    Filed: March 13, 1986
    Date of Patent: November 25, 1986
    Assignee: Pennwalt Corporation
    Inventors: Vassil S. Georgiev, Robert A. Mack
  • 4,5-dihydro-4-oxo-2-[(2-trans-phenylcyclopropyl)amino]-3-furancarboxylic acids and derivatives thereof
    Patent number: 4614810
    Abstract: 4,5-dihydro-4-oxo-2-[(2-trans-phenylcyclopropyl)amino]-3-furancarboxylic acids and derivatives are described.
    Type: Grant
    Filed: September 24, 1984
    Date of Patent: September 30, 1986
    Assignee: Pennwalt Corporation
    Inventors: Vassil S. Georgiev, Robert A. Mack, Clyde R. Kinsolving
  • Substituted spiro[oxazolidine-5,2'-adamantane] compounds
    Patent number: 4600782
    Abstract: Substituted spiro[oxazolidine-5,2'-adamantane] compounds are described.
    Type: Grant
    Filed: June 15, 1984
    Date of Patent: July 15, 1986
    Assignee: Pennwalt Corporation
    Inventors: Vassil S. Georgiev, Clyde R. Kinsolving
  • Substituted 2,3-dihydro-5H-thiazolo[2,3,-b]quinazoline derivatives
    Patent number: 4588812
    Abstract: Novel derivatives of 2,3-dihydro-5H-thiazolo[2,3-b]quinazoline, such as (3-oxo-5H-thiazolo[2,3-b]quinazolin-2(3H)-ylidene)acetic acid ethyl ester, N-Benzyl-[3-oxo-5H-thiazolo[2,3-b]quinazolin-2(3H)-ylidene]acetamide, N-tertbutyl-N-benzyl-(3-oxo-5H-thiazolo[2,3-b]quinazolin-2(3H)-ylidene)ace tamide, and 2,3-dihydro-3-oxo-5H-thiazolo[2,3-b]quinazoline-2-acetic acid methyl ester; useful as immunomodulators.
    Type: Grant
    Filed: May 30, 1984
    Date of Patent: May 13, 1986
    Assignee: Pennwalt Corporation
    Inventors: Grace A. Saeva, Vassil S. Georgiev
  • Substituted 4-azatricyclo[4.3.1.1.sup.3,8 ]undecane compounds
    Patent number: 4557865
    Abstract: 5-Substituted and/or N-Substituted 4-azatricyclo [4.3.1.1.sup.3,8 ]undecane and 4-azatricyclo[4.3.1.1.sup.3,8 ]undecan-5-one compounds are prepared.
    Type: Grant
    Filed: May 7, 1984
    Date of Patent: December 10, 1985
    Assignee: Pennwalt Corporation
    Inventors: Vassil S. Georgiev, Clyde R. Kinsolving
  • Adamantyl containing 1,4-oxazinone derivatives
    Patent number: 4549014
    Abstract: Antimicrobial or anti-inflammatory 1,4-oxazinone derivatives of the structure: ##STR1## wherein one of R and R.sup.1 is hydrogen and the other is --CH.sub.2 CO.sub.2 R.sup.6 (R.sup.6 =alkyl) or R and R.sup.1 together represent the group .dbd.CHCO.sub.2 R.sup.6, R.sup.2 and R.sup.3 are hydrogen, alkyl, substituted alkyl, phenyl or substituted phenyl or R.sup.2 and R.sup.3 together represent a single adamantyl group, and R.sup.4 and R.sup.5 are hydrogen, alkyl, substituted alkyl, phenyl, substituted phenyl, or benzyl, are disclosed herein.
    Type: Grant
    Filed: September 6, 1984
    Date of Patent: October 22, 1985
    Assignee: Pennwalt Corporation
    Inventors: Vassil S. Georgiev, George B. Mullen