Abstract: Disclosed herein are antibodies, antigen binding fragments thereof, and antibody drug conjugates thereof that bind human CD48. Also disclosed are pharmaceutical compositions comprising the antibodies, antigen binding fragments thereof, and antibody drug conjugates thereof; and methods of making and using such pharmaceutical compositions for treating cancer in a patient in need of treatment.

Abstract: Anti-CD48 antibody-drug conjugates are disclosed. The anti-CD48 antibody-drug conjugates comprise an Mcl-1 inhibitor drug moiety and an anti-CD48 antibody or antigen-binding fragment thereof that binds an antigen target, e.g., an antigen expressed on a tumor or other cancer cell. The disclosure further relates to methods and compositions for use in the treatment of cancers by administering the antibody-drug conjugates provided herein. Linker-drug conjugates comprising an Mcl-1 inhibitor drug moiety and methods of making same are also disclosed.

Abstract: Disclosed herein are antibodies, antigen binding fragments thereof, and antibody drug conjugates thereof that bind human CD48. Also disclosed are pharmaceutical compositions comprising the antibodies, antigen binding fragments thereof, and antibody drug conjugates thereof; and methods of making and using such pharmaceutical compositions for treating cancer in a patient in need of treatment.

Abstract: A safety gate assembly includes a frame which may be secured across a door opening, stairway or the like and comprises a base and two upstanding limbs and a gate. One side of the gate is connected by one or more pivotal connections to the one limb of the frame to permit pivotable movement of the gate with respect to the frame about a pivotal axis. The other side of the gate carries a latch member, which cooperates with a latch connected to the other limb of the frame. The latch defines a locked position, in which pivotable movement of the gate is prevented. The pivotal connection is constructed to permit linear movement of the gate relative to the frame in a direction parallel to the pivotal axis. The latch member cooperates with a biasing spring arranged to urge the latch member in the direction away from the said one side of the gate.