Patents by Inventor Vaughn A. Starnes

Vaughn A. Starnes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeting pharmaceutical agents to injured tissues
    Patent number: 6955898
    Abstract: The present invention provides new compositions and methods to induce therapeutic angiogenesis locally utilizing a collagen binding domain to target an angiogenesis modulating agents. Fusion polypeptides containing a collagen binding domain linked to an angiogenesis modulating agent are provided, as are nucleic acid sequences encoding the fusion polypeptides. Also included are methods for locally altering circulation by administering a fusion polypeptide consisting of a collagen binding domain linked to an angiogenesis modulating agent, or by administering a nucleic acid sequences encoding the fusion polypeptide. Tissue grafts in which isolated tissue is treated with a fusion polypeptide consisting of a collagen binding domain linked to an angiogenesis modulating agent, or with a nucleic acid sequences encoding the fusion polypeptide are also provided, as are methods of making the grafts.
    Type: Grant
    Filed: April 17, 2002
    Date of Patent: October 18, 2005
    Assignee: University of Southern California
    Inventors: Frederick L. Hall, Erlinda M. Gordon, Vaughn A. Starnes, W. French Anderson
  • Modified viral surface proteins for binding to extracellular matrix components
    Patent number: 6864082
    Abstract: A viral or non-viral vector particle having a modified viral surface protein wherein the viral surface protein is modified to include a targeting polypeptide including a binding region which binds to an extracellular matrix component. Such vector particles are useful in delivering genes encoding therapeutic agents to cells located at the site of an exposed extracellular matrix component.
    Type: Grant
    Filed: July 13, 2001
    Date of Patent: March 8, 2005
    Assignee: University of Southern California
    Inventors: Frederick L. Hall, Erlinda Maria Gordon, W. French Anderson, Vaughn A. Starnes
  • Modified viral surface proteins for binding to extracellular matrix components
    Publication number: 20030118551
    Abstract: A viral or non-viral vector particle having a modified viral surface protein wherein the viral surface protein is modified to include a targeting polypeptide including a binding region which binds to an extracellular matrix component. Such vector particles are useful in delivering genes encoding therapeutic agents to cells located at the site of an exposed extracellular matrix component.
    Type: Application
    Filed: July 13, 2001
    Publication date: June 26, 2003
    Applicant: University of Southern California
    Inventors: Frederick L. Hall, Erlinda Maria Gordon, W. French Anderson, Vaughn A. Starnes
  • Targeting pharmaceutical agents to injured tissues
    Publication number: 20020164719
    Abstract: The present invention provides new compositions and methods to induce therapeutic angiogenesis locally utilizing a collagen binding domain to target an angiogenesis modulating agents. Fusion polypeptides containing a collagen binding domain linked to an angiogenesis modulating agent are provided, as are nucleic acid sequences encoding the fusion polypeptides. Also included are methods for locally altering circulation by administering a fusion polypeptide consisting of a collagen binding domain linked to an angiogenesis modulating agent, or by administering a nucleic acid sequences encoding the fusion polypeptide. Tissue grafts in which isolated tissue is treated with a fusion polypeptide consisting of a collagen binding domain linked to an angiogenesis modulating agent, or with a nucleic acid sequences encoding the fusion polypeptide are also provided, as are methods of making the grafts.
    Type: Application
    Filed: April 17, 2002
    Publication date: November 7, 2002
    Applicant: University of Southern California
    Inventors: Frederick L. Hall, Erlinda M. Gordon, Vaughn A. Starnes, W. French Anderson
  • Targeting pharmaceutical agents to injured tissues
    Patent number: 6387663
    Abstract: The present invention provides new compositions and methods to induce therapeutic angiogenesis locally utilizing a collagen binding domain to target an angiogenesis modulating agents. Fusion polypeptides containing a collagen binding domain linked to an angiogenesis modulating agent are provided, as are nucleic acid sequences encoding the fusion polypeptides. Also included are methods for locally altering circulation by administering a fusion polypeptide consisting of a collagen binding domain linked to an angiogenesis modulating agent, or by administering a nucleic acid sequences encoding the fusion polypeptide. Tissue grafts in which isolated tissue is treated with a fusion polypeptide consisting of a collagen binding domain linked to an angiogenesis modulating agent, or with a nucleic acid sequences encoding the fusion polypeptide are also provided, as are methods of making the grafts.
    Type: Grant
    Filed: July 31, 1998
    Date of Patent: May 14, 2002
    Assignee: University of Southern California
    Inventors: Frederick L. Hall, Erlinda M. Gordon, Vaughn A. Starnes, W. French Anderson