Patents by Inventor Veeraiah Bodepudi

Veeraiah Bodepudi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS FOR IMPROVED ALLELE-SPECIFIC PCR
    Publication number: 20160369330
    Abstract: The present invention includes compositions for allele-specific amplification, utilizing an allele-specific oligonucleotide, at least partially complementary to more than one variant of the target sequence, but having at least one selective nucleotide complementary to only one variant of the target sequence and incorporating at least one G-damp nucleotide.
    Type: Application
    Filed: September 1, 2016
    Publication date: December 22, 2016
    Inventors: Veeraiah Bodepudi, Nancy Schoenbrunner, Alison Tsan
  • Use of G-clamp for improved allele-specific PCR
    Patent number: 9476091
    Abstract: The present invention includes a method of allele-specific amplification, utilizing an allele-specific oligonucleotide, at least partially complementary to more than one variant of the target sequence, but having at least one selective nucleotide complementary to only one variant of the target sequence and incorporating at least one “G-clamp” nucleotide.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: October 25, 2016
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Veeraiah Bodepudi, Nancy Schoenbrunner, Alison Tsan
  • Methods and reagents for reducing non-specific amplification
    Patent number: 9410195
    Abstract: The present invention provides reagents for use in the amplification of nucleic acids. Amplification carried out using oligonucleotides containing modified nucleotides can result in less non-specific amplification compared to amplification carried out using unmodified oligonucleotides.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: August 9, 2016
    Assignee: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Veeraiah Bodepudi, Nancy Schoenbrunner, Stephen Will
  • Alkyl amines improve detection of components of formaldehyde-fixed biological samples
    Patent number: 9400235
    Abstract: Alkyl amines act to release formaldehyde cross-linking that occurs in biological samples. Thus, contacting alkyl amines to formaldehyde fixed samples is a useful way to render biological components of the samples, including nucleic acids or proteins, more accessible to detection and characterization.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: July 26, 2016
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Stephen G. Will, Veeraiah Bodepudi, Ellen H. Fiss, Rachel Shahinian
  • METHODS AND REAGENTS FOR REDUCING NON-SPECIFIC AMPLIFICATION
    Publication number: 20150322502
    Abstract: The present invention provides reagents for use in the amplification of nucleic acids. Amplification carried out using oligonucleotides containing modified nucleotides can result in less non-specific amplification compared to amplification carried out using unmodified oligonucleotides.
    Type: Application
    Filed: July 17, 2015
    Publication date: November 12, 2015
    Inventors: Veeraiah Bodepudi, Nancy Schoenbrunner, Stephen Will
  • Methods and reagents for reducing non-specific amplification
    Patent number: 9115394
    Abstract: The present invention provides methods and reagents for use in the amplification of nucleic acids. Amplification carried out using oligonucleotides containing modified nucleotides can result in less non-specific amplification compared to amplification carried out using unmodified oligonucleotides.
    Type: Grant
    Filed: December 11, 2012
    Date of Patent: August 25, 2015
    Assignee: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Veeraiah Bodepudi, Nancy Schoenbrunner, Stephen Will
  • ALKYL AMINES IMPROVE DETECTION OF COMPONENTS OF FORMALDEHYDE-FIXED BIOLOGICAL SAMPLES
    Publication number: 20140120547
    Abstract: Alkyl amines act to release formaldehyde cross-linking that occurs in biological samples. Thus, contacting alkyl amines to formaldehyde fixed samples is a useful way to render biological components of the samples, including nucleic acids or proteins, more accessible to detection and characterization.
    Type: Application
    Filed: December 23, 2013
    Publication date: May 1, 2014
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Stephen G. Will, Veeraiah Bodepudi, Ellen H. Fiss, Rachel Shahinian
  • Alkyl amines improve detection of components of formaldehyde-fixed biological samples
    Patent number: 8652775
    Abstract: Alkyl amines act to release formaldehyde cross-linking that occurs in biological samples. Thus, contacting alkyl amines to formaldehyde fixed samples is a useful way to render biological components of the samples, including nucleic acids or proteins, more accessible to detection and characterization.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: February 18, 2014
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Stephen G. Will, Veeraiah Bodepudi, Ellen H. Fiss, Rachel Shahinian
  • 2?-terminator nucleotide-related methods and systems
    Patent number: 8163487
    Abstract: The present invention provides methods of extending primer nucleic acids and sequencing target nucleic acids. The methods include the use of 2?-terminator nucleotides to effect chain termination. In addition to related reaction mixtures and kits, the invention also provides computers and computer readable media.
    Type: Grant
    Filed: March 10, 2011
    Date of Patent: April 24, 2012
    Assignee: Roche Molecular Systems, Inc.
    Inventors: David Harrow Gelfand, Fred Lawrence Reichert, Veeraiah Bodepudi, Amar Gupta, Stephen Will, Thomas W. Myers
  • 2'-Terminator Nucleotide-Related Methods and Systems
    Publication number: 20110201002
    Abstract: The present invention provides methods of extending primer nucleic acids and sequencing target nucleic acids. The methods include the use of 2?-terminator nucleotides to effect chain termination. In addition to related reaction mixtures and kits, the invention also provides computers and computer readable media.
    Type: Application
    Filed: March 10, 2011
    Publication date: August 18, 2011
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: David Harrow Gelfand, Fred Lawrence Reichert, Veeraiah Bodepudi, Amar Gupta, Stephen Will, Thomas Myers
  • Synthesis and compositions of 2'-terminator nucleotides
    Patent number: 7947817
    Abstract: The invention provides compositions that comprise nucleotides and/or nucleosides having blocking groups at 2?-positions of sugar moieties. Methods of synthesizing these nucleic acids are also provided.
    Type: Grant
    Filed: June 28, 2004
    Date of Patent: May 24, 2011
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Veeraiah Bodepudi, Stephen Gordon Will, David Harrow Gelfand
  • Synthesis and compositions of nucleic acids comprising 2?-terminator nucleotides
    Patent number: 7928207
    Abstract: The invention provides methods of producing blocked oligonucleotides that include 2?-terminator nucleotides. These blocked oligonucleotides are used primers and probes in a variety of nucleic acid technologies. Related kits are also provided.
    Type: Grant
    Filed: October 18, 2006
    Date of Patent: April 19, 2011
    Assignee: Roche Molecular Systems, Inc
    Inventors: Veeraiah Bodepudi, Amar P. Gupta, Stephen G. Will
  • 2?-Terminator nucleotide-related methods and systems
    Patent number: 7919249
    Abstract: The present invention provides methods of extending primer nucleic acids and sequencing target nucleic acids. The methods include the use of 2?-terminator nucleotides to effect chain termination. In addition to related reaction mixtures and kits, the invention also provides computers and computer readable media.
    Type: Grant
    Filed: July 16, 2008
    Date of Patent: April 5, 2011
    Assignee: Roche Molecular Systems, Inc.
    Inventors: David Harrow Gelfand, Fred Lawrence Reichert, Veeraiah Bodepudi, Amar Gupta, Stephen Will, Thomas Myers
  • 2?-terminator related pyrophosphorolysis activated polymerization
    Patent number: 7745125
    Abstract: The present invention provides reaction mixtures that include blocked oligonucleotides comprising 2?-terminator nucleotides. The blocked oligonucleotides are rendered extendible when the 2?-terminator nucleotides are removed from the oligonucleotides, e.g., via pyrophosphorolysis. The reaction mixtures can be used in various nucleic acid polymerization and/or amplification assays, among many other applications. In addition to reaction mixtures, the invention also provides related methods and reaction mixtures.
    Type: Grant
    Filed: October 18, 2006
    Date of Patent: June 29, 2010
    Assignee: Roche Molecular Systems, Inc.
    Inventors: David H. Gelfand, Keith A. Bauer, Amar P. Gupta, Veeraiah Bodepudi, John Niemiec
  • 2?-terminator nucleotide-related methods and systems
    Patent number: 7572581
    Abstract: The present invention provides methods of extending primer nucleic acids and sequencing target nucleic acids. The methods include the use of 2?-terminator nucleotides to effect chain termination. In addition to related reaction mixtures and kits, the invention also provides computers and computer readable media.
    Type: Grant
    Filed: June 28, 2004
    Date of Patent: August 11, 2009
    Assignee: Roche Molecular Systems, Inc.
    Inventors: David Harrow Gelfand, Fred Lawrence Reichert, Veeraiah Bodepudi, Amar Gupta, Stephen Will, Thomas Myers
  • 2'-Terminator Nucleotide-Related Methods and Systems
    Publication number: 20090142810
    Abstract: The present invention provides methods of extending primer nucleic acids and sequencing target nucleic acids. The methods include the use of 2?-terminator nucleotides to effect chain termination. In addition to related reaction mixtures and kits, the invention also provides computers and computer readable media.
    Type: Application
    Filed: July 16, 2008
    Publication date: June 4, 2009
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: David Harrow Gelfand, Fred Lawrence Reichert, Veeraiah Bodepudi, Amar Gupta, Stephen Will, Thomas W. Myers
  • Alkyl amines improve detection of components of formaldehyde-fixed biological samples
    Publication number: 20090081661
    Abstract: Alkyl amines act to release formaldehyde cross-linking that occurs in biological samples. Thus, contacting alkyl amines to formaldehyde fixed samples is a useful way to render biological components of the samples, including nucleic acids or proteins, more accessible to detection and characterization.
    Type: Application
    Filed: March 28, 2008
    Publication date: March 26, 2009
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Stephen G. Will, Veeraiah Bodepudi, Ellen H. Fiss, Rachel Shahinian
  • Detectable labeled nucleoside analogs and methods of use thereof
    Patent number: 7501504
    Abstract: The invention relates to detectable labels useful for detection of nucleotide sequences. Specifically, the invention relates to labeled-imidazole-PEG compounds, such as nucleosides, nucleotides, and nucleic acids incorporating such compounds, and methods utilizing such compounds. The invention further relates to kits comprising labeled imidazole-PEG compounds.
    Type: Grant
    Filed: April 30, 2007
    Date of Patent: March 10, 2009
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Veeraiah Bodepudi, Amar Gupta, Stephen Gordon Will
  • Detectable labeled nucleoside analogs and methods of use thereof
    Patent number: 7456266
    Abstract: The invention relates to detectable labels useful for detection of nucleotide sequences. Specifically, the invention relates to labeled-imidazole-PEG compounds, such as nucleosides, nucleotides, and nucleic acids incorporating such compounds, and methods utilizing such compounds. The invention further relates to kits comprising labeled imidazole-PEG compounds.
    Type: Grant
    Filed: April 30, 2007
    Date of Patent: November 25, 2008
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Veeraiah Bodepudi, Amar Gupta, Stephen Gordon Will
  • Detectable labeled nucleoside analogs and methods of use thereof
    Patent number: 7452674
    Abstract: The invention relates to detectable labels useful for detection of nucleotide sequences. Specifically, the invention relates to labeled-imidazole-PEG compounds, such as nucleosides, nucleotides, and nucleic acids incorporating such compounds, and methods utilizing such compounds. The invention further relates to kits comprising labeled imidazole-PEG compounds.
    Type: Grant
    Filed: April 30, 2007
    Date of Patent: November 18, 2008
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Veeraiah Bodepudi, Amar Gupta, Stephen G. Will