Abstract: The invention provides a process by which tubular tissue supports (stents) can be removed from hollow organs of humans or of animals after heating to a temperature below the transition temperature Ttrans until softening occurs.

Abstract: A device for purification of blood, blood substitutes or solutions for the introduction into the human and/or animal blood circulation and for gas exchange in blood, blood substitutes or solutions for the introduction into the human and/or animal blood circulation, includes at least one gas permeable membrane and a carrier, coated with substances for adsorptive removal of toxins of biological and chemical synthetic origin, their metabolites and degradation products present in blood, blood substitutes or solutions for the introduction into the human and/or animal blood circulation, a use of the aforementioned device and a process for gentle and simultaneous removal of toxins of biological and chemical synthetic origin, their metabolites and degradation products present in blood, blood substitutes or solutions for the introduction into the human and/or animal blood circulation and for enrichment of blood, blood substitutes or solutions for the introduction into the human and/or animal blood circulation with oxy

Abstract: An adsorbent for whole blood in the form of essentially spherical non-aggregated particles. The adsorbent comprises a porous carrier material having an average pore size of ?1.5 ?m, whereby a maximum of 50% of the pore volume may be in pores having a pore size of >1.5 ?m, whereby the outer surfaces of the porous carrier material have at least one surface modification M1 so that the outer surface essentially does not interact with blood cells, and the inner surfaces of the porous carrier material, e.g., the surfaces of the pores of the porous carrier material, have at least one surface modification M2 which interacts with substances present in blood.

Abstract: The invention provides a process by which tubular tissue supports (stents) can be removed from hollow organs of humans or of animals after heating to a temperature below the transition temperature Ttrans until softening occurs.

Abstract: This invention relates to an adsorbent for lowering the concentration of fibrinogen and/or fibrin in the blood or blood plasma, encompassing an organic matrix with synthetic side chains covalently bound to the matrix and exhibiting terminal vicinal hydroxy groups formed by the hydrolysis of terminal epoxy groups, which synthetic side chains are free of peptides and of any groups of aromatics. The invention further relates to a method for preparing the adsorbent, and to the use of the adsorbent for producing an adsorber serving to lower the concentration of fibrinogen and/or fibrin in the blood or blood plasma.

Abstract: An adsorbent for whole blood in the form of essentially spherical non-aggregated particles. The adsorbent comprises a porous carrier material having an average pore size of ≦1.5 &mgr;m, whereby a maximum of 50% of the pore volume may be in pores having a pore size of >1.5 &mgr;m, whereby the outer surfaces of the porous carrier material have at least one surface modification M1 so that the outer surface essentially does not interact with blood cells, and the inner surfaces of the porous carrier material, e.g., the surfaces of the pores of the porous carrier material, have at least one surface modification M2 which interacts with substances present in blood.

Abstract: A process for manufacturing an adsorbent for reducing the concentration of fibrinogen and/or fibrin in blood or blood plasma in which a carrier material, which is preferably a copolymer derived from (meth)acrylates and or (meth)acrylic acid amides, is activated by amination, and subsequently undergoes thermal treatment at a temperature of over 100° C. An adsorber for the purpose of reducing the concentration of fibrinogen and/or fibrin in blood or blood plasma may be produced from the adsorbent.

Abstract: An adsorbent for reducing the concentration of fibrinogen and/or fibrin in blood or blood plasma comprises a matrix and synthetic lateral chains that are covalently bonded to the matrix. The lateral synthetic chains are comprised of at least two amino groups in which the N2 atoms are at least 2.6 Å apart within at least one lateral synthetic chain. The matrix exhibits porous, unaggregated, spherical particles in a range of particle sizes from 50 to 250 &mgr;m, which possess an exclusionary threshold of at least 107 Daltons, and they exhibit no peptides or aromatic groups of any kind. The at least two amino groups are preferably separated from one another by 4 to 6 carbon atoms. An adsorber for the purpose of reducing the concentration of fibrinogen and/or fibrin in blood or blood plasma may be produced from the adsorbent.

Abstract: The present invention relates to a ligand for bacterial toxins, particularly entero- or exotoxins of gram-positive bacteria, which is capable of selective interaction with a structure containing an amino acid sequence conserved in the bacterial toxins. The invention also relates to an adsorbent that exhibits the ligand bound to a matrix, an adsorption device for reducing the concentration of bacterial toxins in blood or blood plasma as well as a pharmaceutical composition, which contains the ligands, and which is suitable in particular for the treatment and/or prevention of gram-positive sepsis.

Abstract: An adsorbent for reducing the concentration of fibrinogen and/or fibrin in blood or blood plasma comprises a matrix and synthetic lateral chains that are covalently bonded to the matrix. The matrix can, in principle, consist of any arbitrary carriers; however, it exhibits, preferably, porous, unaggregated, spherical particles in a range of particle sizes from 50 to 250 &mgr;m, which possess an exclusionary threshold of at least 107 Daltons. The lateral chains possess at least two amino groups whose nitrogen atoms in the chain are at least 2.6 Angstroms removed from one another, and they exhibit no peptides or aromatic groups of any kind. The at least two amino groups are preferably separated from one another by 4 to 6 carbon atoms. An adsorber for the purpose of reducing the concentration of fibrinogen and/or fibrin in blood or blood plasma may be produced from the adsorbent.

Abstract: A process for manufacturing an adsorbent for reducing the concentration of fibrinogen and/or fibrin in blood or blood plasma in which a carrier material, which is preferably a copolymer derived from (meth)acrylates and or (meth)acrylic acid amides, is activated by amination, and subsequently undergoes thermal treatment at a temperature of over 100° C. An adsorber for the purpose of reducing the concentration of fibrinogen and/or fibrin in blood or blood plasma may be produced from the adsorbent.

Abstract: The invention relates to a device for purifying protein-containing solutions such as blood, blood plasma or cell culture media, where a biocompatible support material made of a plastic material, selected from the group of polyacrylates, polymethacrylates, polysulfone and polyether sulfone, is coated with albumin, which is bound by peptide binding. In addition, the invention relates to a method of producing the support material according to this invention and the use of the device.

Abstract: A material for the elimination of biomacromolecules, in particular LDL and endotoxins from a whole blood circuit, comprising an adsorbent, comprising a porous carrier material of a homo-, co-, or terpolymer of acrylic acid and/or methacrylic acid with a particle range of between 50 and 250 .mu.m, an exclusion level of at least 5.times.10.sup.5 daltons, as well as organic ligands which are covalently bound to the carrier material via a spacer, wherein the carrier material has a spherical shape and suitably, the spacer contains no double bonds.

Abstract: An improved apparatus (10) is made available for separating at least two biological substances in solution by adsorption and comprises in the upper interior section (28) of its housing (10) a means effecting a partial constriction of the cross-section of said interior section (28), said section thereby being divided into an upper and lower subspace (34; 36), and which is further distinguished in that the upper subspace (34) and the lower subspace (36) are in flow connection with each other both as regards the solution to be separated and the adsorption agent particles, the feed tube (40) for the solution to be separated being arranged in such a manner that the discharge of the solution to be separated takes place in the lower subspace (36), and the apparatus is a self-contained in unit in sterile form.