Patents by Inventor Vera Gorbunova

Vera Gorbunova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for recombinant synthesis of high molecular weight hyaluronic acid
    Patent number: 9315588
    Abstract: Provided is a novel hyaluronan synthase (HAS2), isolated nucleic acids encoding it, and expression vectors which express the novel HAS2. Also provided are cell cultures which contain cells which harbor the expression vectors, methods of using the cell cultures to produce high molecular weight hyaluronic acid, and cell culture media that contains the high molecular weight hyaluronic acid.
    Type: Grant
    Filed: February 4, 2013
    Date of Patent: April 19, 2016
    Assignee: University of Rochester
    Inventors: Vera Gorbunova, Andrei Seluanov
  • Compositions and Methods for Recombinant Synthesis of High Molecular Weight Hyaluronic Acid
    Publication number: 20140378678
    Abstract: Provided is a novel hyaluronan synthase (HAS2), isolated nucleic acids encoding it, and expression vectors which express the novel HAS2. Also provided are cell cultures which contain cells which harbor the expression vectors, methods of using the cell cultures to produce high molecular weight hyaluronic acid, and cell culture media that contains the high molecular weight hyaluronic acid.
    Type: Application
    Filed: February 4, 2013
    Publication date: December 25, 2014
    Applicant: University of Rochester
    Inventors: Vera Gorbunova, Andrei Seluanov
  • Compositions Comprising High Molecular Weight Hyaluronic Acid and Methods For Producing Same
    Publication number: 20130131009
    Abstract: This invention provides cell culture compositions which produce significant quantities of high molecular weight hyaluronic acid. The cell cultures are obtained from cells of mole rats, such as naked mole rats and blind mole rats. The high molecular weight hyaluronic acid can be collected in the conditioned media of these cell cultures. These cell cultures provide a convenient source of large quantities of high molecular weight hyaluronic acid.
    Type: Application
    Filed: March 24, 2011
    Publication date: May 23, 2013
    Applicant: UNIVERSITY OF ROCHESTER
    Inventors: Vera Gorbunova, Andrei Seluanov, Christopher Hine
  • Rad51 derived cancer cell specific promoters for targeted anti-cancer therapy
    Patent number: 8188252
    Abstract: Provided are compositions and methods for inhibiting growth of cancer cells. The method of the invention relates to delivering to cells an effective amount of a composition that contains a polynucleotide having a Rad51 promoter or a polynucleotide having at least 95% similarity to a Rad51 promoter. The Rad51 promoter is operably linked to a coding region for a cytotoxic agent. In vitro and in vivo results demonstrating effectiveness of the polynucleotides of the invention are presented.
    Type: Grant
    Filed: November 17, 2009
    Date of Patent: May 29, 2012
    Assignee: University of Rochester
    Inventors: Christopher M. Hine, Andrei Seluanov, Vera Gorbunova
  • RAD51 DERIVED CANCER CELL SPECIFIC PROMOTERS FOR TARGETED ANTI- CANCER THERAPY
    Publication number: 20100130596
    Abstract: Provided are compositions and methods for inhibiting growth of cancer cells. The method of the invention relates to delivering to cells an effective amount of a composition that contains a polynucleotide having a Rad51 promoter or a polynucleotide having at least 95% similarity to a Rad51 promoter. The Rad51 promoter is operably linked to a coding region for a cytotoxic agent. In vitro and in vivo results demonstrating effectiveness of the polynucleotides of the invention are presented.
    Type: Application
    Filed: November 17, 2009
    Publication date: May 27, 2010
    Inventors: Christopher M. Hine, Andrei Seluanov, Vera Gorbunova
  • Induction method for cell differentiation
    Publication number: 20050180953
    Abstract: The invention relates to the induction method for cell differentiation which consists in injecting peptide derivatives having the following general formula (I): and used as a differentiation-inducing factor. Said peptide derivatives are used for curing oncological diseases, in particular for stabilising melanoma growth, increasing the efficiency of melanoma immunotherapy and reducing haematological toxicity of chemotherapy. The utilisation of said peptide derivatives is also disclosed.
    Type: Application
    Filed: February 28, 2003
    Publication date: August 18, 2005
    Applicant: NEBOLSIN, Vladimir Evgenievich
    Inventors: Vladimir Nebolsin, Vera Gorbunova, Ivan Treschalin, Natan Raikhlin, Avgust Garin, Mark Bychkov, Elena Treschalina, Galina Zheltukhina