Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: The present disclosure provides a positioning method and system for autonomous driving through Long Short-Term Memory (LSTM)-based Deep Reinforcement Learning (DRL). The method includes: performing normalization preprocessing on a complex environment of autonomous driving based on a Partially Observable Markov Decision Process (POMDP), to acquire a real-time kinematic (RTK) positioning result; inputting the RTK positioning result into an LSTM-based DRL model for correction to acquire an evaluated value of a position correction action; and performing position correction on an autonomous vehicle based on the evaluated value of the position correction action. The system includes a prediction module, a correction module, and an application module. The present disclosure considers that autonomous driving is highly dynamic, temporal, and complex in a complex environment, and generates a more accurate satellite positioning position.

Abstract: Disclosed are systems and methods for location tracking. In one embodiment, an apparatus receives a message sent to a user of a mobile device in a wireless network, and a processor determines at least one location parameter. Data is extracted from the message, and initiation of a computing function (e.g., transmission of a communication to the mobile device) is triggered by a match between the location and the data from the message.

Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: A gaming machine includes a base, a columnar pedestal extending vertically from the base, and a button deck adjustably coupled to the pedestal. The button deck includes an upper surface including a transparent touchscreen element, a lower surface opposite the upper surface, and a button deck body extending therebetween. At least one of the lower surface and the body include one or more transparent display elements, the one or more transparent display elements are configured to generate images of gaming machine control actuators viewable on the upper surface. The transparent touchscreen element is configured to receive touches and gestures indicating control inputs. The gaming machine also includes a player tracking card reader positioned within the button deck and accessible through a slot in a front edge of the button deck, the player tracking card reader communicatively coupled to a player tracking display area of the gaming machine.

Abstract: A method of balancing a dataset for a machine learning model includes identifying confusing classes of few-shot classes for a machine learning model during validation. One of the confusing classes and an image from one of the few-shot classes are selected. An image perturbation is computed such that the selected image is classified as the selected confusing class. The selected image is modified with the computed perturbation. The modified selected image is added to a batch for training the machine learning model.

Abstract: A method for generating optimal arch forms for a patient's dental arch is presented. The method comprises: receiving first positional digital data for one or more teeth from a reconstructed 3D digital volume of the patient dental arch; (b) generating second positional digital data for the one or more teeth according to a desired dental arch form for the patient; (c) calculating a first displacement data for one or more teeth according to the first positional and second positional digital data; (d) detecting teeth collision values based on the first displacement data; (e) calculating a second displacement data for one or more teeth based on the detected teeth collision values; and (f) reporting a combination of the first displacement data and second displacement data for repositioning one tooth or more teeth of the dental arch.

Abstract: Aspects of the subject technology provide improved techniques for gesture recognition. Improved techniques may include detecting and/or classifying an interaction between the body part and another object in a scan of the body part, and then controlling recognition of a gesture based on the interaction. In an aspect, recognition parameters may be selected based on the interaction classification that disable recognition of one or more gestures while not disabling recognition of other gestures.

Abstract: Various embodiments of the present application set forth a computer-implemented method comprising determining a set of digital assets to transfer to a destination device, generating, from the set of digital assets, a corresponding set of chunks, where each chunk is a pre-defined size, for each chunk in the set of chunks, transmitting the chunk to a service node included in a set of service nodes, and verifying that the service node received the chunk, where the set of service nodes receives at least two chunks of the set of chunks in parallel, and after the set of service nodes send the at least two chunks in parallel to the destination device, verifying that the destination device received the set of chunks.

Abstract: A scale and pose estimation method for a camera system is disclosed. Camera data for a scene acquired by the camera system is received. A scale prior parameter characterizing scale of the camera system is received. A cost of a cost function is calculated for a similarity transformation. The cost of the cost function is influenced at least by the scale prior parameter. Based at least on the cost function being less than a threshold cost, an estimated scale and pose of the camera system is output based on the similarity transformation.

Abstract: An electronic device may be provided with an antenna having a resonating element and a light source module mounted to a flexible printed circuit and a metal cowling. The module may emit light through a rear housing wall. The printed circuit may be interposed between the metal cowling and a conductive support plate in the rear housing wall. The printed circuit may include a ground trace coupled to the resonating element. A dimpled pad may couple the ground trace to the support plate. Compressive foam may be used to exert a force against the flexible printed circuit that presses the dimpled pad against the conductive support plate. The ground trace and the dimpled pad may form a return path to ground for the resonating element. The dimpled pad may occupy less height within the device than other structures such as metal springs.

Abstract: The present invention generally provides methods and compositions for eliciting an immune response against Neisseria spp. bacteria in a subject, particularly against a Neisseria meningitidis serogroup B strain.

Abstract: The disclosure provides a filtration system for a cell culture apparatus and a method of cell culture. The filtration system comprises a bioreactor vessel and two or more alternating tangential flow (ATF) filters connected in parallel. A failure in either filter is detected by an in-line sensor, and an automated response system functions to sequester the malfunctioning filter by stopping the flow of liquid media through the filter. Media flow through the remaining operable filters can be increased so that the rate of perfusion through the bioreactor remains relatively unchanged. Such a system may prevent issues that arise from ATF filter failures in conventional perfusion bioreactors, thereby improving the long-term viability of cell cultures.

Abstract: The present disclosure relates to heterocyclyl pyridazine compounds, processes and intermediates for their preparation as well as the uses thereof for controlling phytopathogenic microorganisms, such as phytopathogenic fungi.

Abstract: The present disclosure relates to pyridazine (thio)amide compounds, processes and intermediates for their preparation as well as the uses thereof for controlling phytopathogenic microorganisms, such as phytopathogenic fungi.

Abstract: The disclosure provides a filtration system for a cell culture apparatus and a method of cell culture. The filtration system comprises a bioreactor vessel and two or more alternating tangential flow (ATF) filters connected in parallel. A failure in either filter is detected by an in-line sensor, and an automated response system functions to sequester the malfunctioning filter by stopping the flow of liquid media through the filter. Media flow through the remaining operable filters can be increased so that the rate of perfusion through the bioreactor remains relatively unchanged. Such a system may prevent issues that arise from ATF filter failures in conventional perfusion bioreactors, thereby improving the long-term viability of cell cultures.

Abstract: Detection of placement of dental aligners in patient mouth on teeth for indication of wearing compliance. Described herein are apparatuses and methods for detecting wearing, including compliance. In some variations these apparatuses and methods may include a sensor configured to detect deflection of the one or more deflectable structures. In some variations, these apparatuses and methods may include a proximity sensor coupled to the appliance shell and configured to generate sensor data when in proximity with intraoral tissue.

Abstract: Methods for fabrication of and use of magnesium oxide sorbents for room temperature carbon dioxide adsorption are provided. In accordance with one aspect, a method for fabrication of sorbents is provided which includes using calcination to obtain MgO—Mg(OH)2 nano-composites and aging the MgO—Mg(OH)2 nano-composites to form nano MCHs for room temperature carbon dioxide adsorption. According to another aspect, a method for fabrication of sorbents which includes fabrication of monoclinic magnesium malate tetrahydrate (C8H10MgO10.4H2O) and use of such sorbents for room temperature carbon dioxide adsorption is provided.

Abstract: Detection of placement of dental aligners in patient mouth on teeth for indication of wearing compliance. Described herein are apparatuses and methods for detecting wearing, including compliance. In some variations these apparatuses and methods may include a sensor configured to detect deflection of the one or more deflectable structures. In some variations, these apparatuses and methods may include a proximity sensor coupled to the appliance shell and configured to generate sensor data when in proximity with intraoral tissue.

Abstract: The disclosure provides a filtration system for a cell culture apparatus and a method of cell culture. The filtration system comprises a bioreactor vessel and two or more alternating tangential flow (ATF) filters connected in parallel. A failure in either filter is detected by an in-line sensor, and an automated response system functions to sequester the malfunctioning filter by stopping the flow of liquid media through the filter. Media flow through the remaining operable filters can be increased so that the rate of perfusion through the bioreactor remains relatively unchanged. Such a system may prevent issues that arise from ATF filter failures in conventional perfusion bioreactors, thereby improving the long-term viability of cell cultures.