Patents by Inventor Victor J. Dzau

Victor J. Dzau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR CONTROLLING BLOOD PRESSURE
    Publication number: 20230313160
    Abstract: The present disclosure describes compositions and methods for treating hypertension in a subject.
    Type: Application
    Filed: November 11, 2022
    Publication date: October 5, 2023
    Inventors: Conrad P. Hodgkinson, Hualing Sun, Richard Pratt, Victor J. Dzau
  • Direct reprogramming of cells to cardiac myocyte fate
    Patent number: 11534464
    Abstract: A method for promoting conversion of cells into cardiomyocytic tissue is carried out by contacting fibrotic tissue (e.g., scar tissue) with a microRNA oligonucleotide or combination of microRNA oligonucleotides. The methods lead to direct reprogramming of fibroblasts to cardiomyocytes or cardiomyoblasts.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: December 27, 2022
    Assignee: Duke University
    Inventors: Victor J. Dzau, Maria Mirotsou, Tilanthi Jayawardena
  • MULTICISTRONIC MIRNA DELIVERY FOR CARDIAC REPROGRAMMING
    Publication number: 20220175845
    Abstract: The invention provides a method of promoting reprogramming of a cardiac fibroblast into a cardiomyocyte by contacting the cardiac fibroblast with an isolated polynucleotide molecule comprising at least two functional miRNA sequences using a multicistronic expression system for reprogramming of fibroblasts into functional mature cardiomyocytes.
    Type: Application
    Filed: December 3, 2021
    Publication date: June 9, 2022
    Inventors: Conrad P. Hodgkinson, Victor J. Dzau
  • DIRECT REPROGRAMMING OF CELLS TO CARDIAC MYOCYTE FATE
    Publication number: 20200345786
    Abstract: A method for promoting conversion of cells into cardiomyocytic tissue is carried out by contacting fibrotic tissue (e.g., scar tissue) with a microRNA oligonucleotide or combination of microRNA oligonucleotides. The methods lead to direct reprogramming of fibroblasts to cardiomyocytes or cardiomyoblasts.
    Type: Application
    Filed: June 29, 2020
    Publication date: November 5, 2020
    Inventors: Victor J. Dzau, Maria Mirotsou, Tilanthi Jayawardena
  • Direct reprogramming of cells to cardiac myocyte fate
    Patent number: 10695378
    Abstract: A method for promoting conversion of cells into cardiomyocytic tissue is carried out by contacting fibrotic tissue (e.g., scar tissue) with a microRNA oligonucleotide or combination of microRNA oligonucleotides. The methods lead to direct reprogramming of fibroblasts to cardiomyocytes or cardiomyoblasts.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: June 30, 2020
    Assignee: Duke University
    Inventors: Victor J. Dzau, Maria Mirotsou, Tilanthi Jayawardena
  • INHIBITION OF HISTONE METHYLTRANSFERASE FOR CARDIAC REPROGRAMMING
    Publication number: 20190192533
    Abstract: A method for promoting the reprogramming of a non-cardiomyocytic cell or tissue into cardiomyocytic cell or tissue comprising is carried out by contacting a non-cardiomyocytic cell or tissue with a modulator of histone methyltransferase activity or expression.
    Type: Application
    Filed: November 19, 2018
    Publication date: June 27, 2019
    Inventors: Victor J. Dzau, Maria Mirotsou
  • Direct Reprogramming of Cells to Cardiac Myocyte Fate
    Publication number: 20180344776
    Abstract: A method for promoting conversion of cells into cardiomyocytic tissue is carried out by contacting fibrotic tissue (e.g., scar tissue) with a microRNA oligonucleotide or combination of microRNA oligonucleotides. The methods lead to direct reprogramming of fibroblasts to cardiomyocytes or cardiomyoblasts.
    Type: Application
    Filed: June 4, 2018
    Publication date: December 6, 2018
    Inventors: Victor J. Dzau, Maria Mirotsou, Tilanthi Jayawardena
  • Inhibition of histone methyltransferase for cardiac reprogramming
    Patent number: 10130637
    Abstract: A method for promoting the reprogramming of a non-cardiomyocytic cell or tissue into cardiomyocytic cell or tissue comprising is carried out by contacting a non-cardiomyocytic cell or tissue with a modulator of histone methyltransferase activity or expression.
    Type: Grant
    Filed: November 4, 2013
    Date of Patent: November 20, 2018
    Assignee: DUKE UNIVERSITY
    Inventors: Victor J. Dzau, Maria Mirotsou
  • Direct reprogramming of cells to cardiac myocyte fate
    Patent number: 9987309
    Abstract: A method for promoting conversion of cells into cardiomyocytic tissue is carried out by contacting fibrotic tissue (e.g., scar tissue) with a microRNA oligonucleotide or combination of microRNA oligonucleotides. The methods lead to direct reprogramming of fibroblasts to cardiomyocytes or cardiomyoblasts.
    Type: Grant
    Filed: July 8, 2011
    Date of Patent: June 5, 2018
    Assignee: DUKE UNIVERSITY
    Inventors: Victor J. Dzau, Maria Mirotsou, Tilanthi Jayawardena
  • Method of reducing cell death by administering a paracrine factor derived from a mesenchymal stem cell
    Patent number: 9353168
    Abstract: A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death and/or tissue injury associated with ischemic conditions.
    Type: Grant
    Filed: April 18, 2014
    Date of Patent: May 31, 2016
    Assignees: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., DUKE UNIVERSITY
    Inventors: Victor J. Dzau, Maria Mirotsou
  • Method of reducing cell death by administering a nucleic acid encoding a paracrine factor of a mesenchymal stem cell
    Patent number: 9279012
    Abstract: A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic conditions.
    Type: Grant
    Filed: April 18, 2014
    Date of Patent: March 8, 2016
    Assignees: The Brigham and Women's Hospital, Inc., Duke University
    Inventors: Victor J. Dzau, Maria Mirotsou
  • Inhibition of Histone Methyltransferase for Cardiac Reprogramming
    Publication number: 20150297611
    Abstract: A method for promoting the reprogramming of a non-cardiomyocytic cell or tissue into cardiomyocytic cell or tissue comprising is carried out by contacting a non-cardiomyocytic cell or tissue with a modulator of histone methyltransferase activity or expression.
    Type: Application
    Filed: November 4, 2013
    Publication date: October 22, 2015
    Inventors: Victor J. Dzau, Maria Mirotsou
  • Stem Cell Derived Factors for Treating Pathologic Conditions
    Publication number: 20140357703
    Abstract: A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic conditions.
    Type: Application
    Filed: April 18, 2014
    Publication date: December 4, 2014
    Inventors: Victor J. Dzau, Maria Mirotsou
  • Stem Cell Derived Factors for Treating Pathologic Conditions
    Publication number: 20140296152
    Abstract: A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic conditions.
    Type: Application
    Filed: April 18, 2014
    Publication date: October 2, 2014
    Applicants: DUKE UNIVERSITY, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Victor J. Dzau, Maria Mirotsou
  • Method of reducing cell death by administering a paracrine factor of a mesenchymal stem cell
    Patent number: 8703710
    Abstract: A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death and/or tissue injury associated with ischemic conditions.
    Type: Grant
    Filed: March 18, 2010
    Date of Patent: April 22, 2014
    Assignees: The Brigham and Women's Hospital, Inc., Duke University
    Inventors: Victor J. Dzau, Maria Mirotsou
  • Direct Reprogramming of Cells to Cardiac Myocyte Fate
    Publication number: 20140011281
    Abstract: A method for promoting conversion of cells into cardiomyocytic tissue is carried out by contacting fibrotic tissue (e.g., scar tissue) with a microRNA oligonucleotide or combination of microRNA oligonucleotides. The methods lead to direct reprogramming of fibroblasts to cardiomyocytes or cardiomyoblasts.
    Type: Application
    Filed: July 8, 2011
    Publication date: January 9, 2014
    Applicant: DUKE UNIVERSITY
    Inventors: Victor J. Dzau, Maria Mirotsou, Tilanthi Jayawardena
  • Use of HASF as a Protective Agent Against Ischemic Tissue Damage
    Publication number: 20120172306
    Abstract: A method of inducing a protective response against ischemic tissue damage is carried out by administering to subject a composition comprising an HASF polypeptide. The composition is administered prior to an ischemic event such as myocardial infarction to reduce tissue damage associated with such an event.
    Type: Application
    Filed: March 15, 2010
    Publication date: July 5, 2012
    Applicant: Duke University
    Inventors: Maria Mirotsou, Victor J. Dzau, Jing Huang
  • MESENCHYMAL STEM CELLS AND METHODS OF USE THEREOF
    Publication number: 20110091430
    Abstract: The invention provides compositions and methods of enhancing the viability of primary stem cells and enhancing the engraftment of transplanted stem cells into a mammalian recipient. Accordingly, the invention includes a method of regenerating a mesenchymally-derived tissue by contacting the tissue with a composition containing an isolated adult mesenchymal stem cell, which are apoptosis-resistant. The mesenchymal stem cell is an adult cell obtained from an adult bone marrow.
    Type: Application
    Filed: January 19, 2010
    Publication date: April 21, 2011
    Inventors: Victor J. Dzau, Abeel Mangi, James Edmund Ip
  • COMPOSITIONS FOR TISSUE REPAIR/REGENERATION
    Publication number: 20110071086
    Abstract: The invention provides compositions and methods for cardiac repair and/or regeneration of tissues such as myocardium.
    Type: Application
    Filed: November 4, 2008
    Publication date: March 24, 2011
    Inventors: Victor J. Dzau, Jian Guo
  • Selective inhibition of vascular smooth muscle cell proliferation
    Publication number: 20040266712
    Abstract: The present invention concerns methods and means for selective inhibition of vascular smooth muscle cell (VMSC) proliferation, without negative impact on the proliferation of endothelial cells. In particular, the invention concerns the inhibition of VMSC proliferation without substantial inhibition of endothelial cell proliferation or function by delivery to a blood vessel in need of healing an E2F decoy oligonucleotide.
    Type: Application
    Filed: April 6, 2004
    Publication date: December 30, 2004
    Inventors: Leslie M. McEvoy, Michael J. Mann, Christi Parham, Victor J. Dzau