Patents by Inventor Victor Nikulin

Victor Nikulin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and compositions as modulators of GPR119 activity
    Patent number: 8575168
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
    Type: Grant
    Filed: October 1, 2010
    Date of Patent: November 5, 2013
    Assignee: IRM LLC
    Inventors: Mihai Azimioara, Christopher Cow, Robert Epple, Gerald Lelais, John Mecom, Victor Nikulin
  • Compounds and methods for modulating G protein-coupled receptors
    Patent number: 8394841
    Abstract: The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating G protein-coupled receptor 120 (GPR120), and methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated GPR120.
    Type: Grant
    Filed: January 8, 2008
    Date of Patent: March 12, 2013
    Assignee: IRM LLC
    Inventors: Robert Epple, Mihai Azimioara, Christopher Cow, Ross Russo, Victor Nikulin, Gerald Lelais
  • 4-phenoxymethylpiperidines as modulators of GPR119 activity
    Patent number: 8334288
    Abstract: The present invention provides compounds of Formula I, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent; diseases or disorders associated with the activity of GPR119.
    Type: Grant
    Filed: July 9, 2009
    Date of Patent: December 18, 2012
    Assignee: IRM LLC
    Inventors: Robert Epple, Gerald Lelais, Victor Nikulin, Lucas Westcott-Baker
  • Compounds and compositions as modulators of GPR119 activity
    Patent number: 8258156
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
    Type: Grant
    Filed: May 23, 2011
    Date of Patent: September 4, 2012
    Assignee: IRM LLC
    Inventors: Phillip B. Alper, Mihai Azimioara, Christopher N. Cow, Robert Epple, Pierre-Yves Michellys, Victor Nikulin
  • COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY
    Publication number: 20120196844
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
    Type: Application
    Filed: March 16, 2012
    Publication date: August 2, 2012
    Applicant: IRM LLC
    Inventors: Phillip B. Alper, Mihai Azimioara, Christopher Cow, Robert Epple, Songchun Jiang, Gerald lelais, Pierre-Yves Michellys, Daniel Mutnick, Victor Nikulin, Lucas Westcott-Baker
  • Compounds and compositions as modulators of GPR119 activity
    Patent number: 8153635
    Abstract: The invention provides compounds of Formula I: wherein A, L, m, q, Q, R1, R2, R3, R4 and R5 are defined in the Summary of the Invention. The invention further provides for pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
    Type: Grant
    Filed: September 4, 2008
    Date of Patent: April 10, 2012
    Assignee: IRM LLC
    Inventors: Phillip B. Alper, Mihai Azimioara, Christopher Cow, Robert Epple, Songchun Jiang, Gerald Lelais, Pierre-Yves Michellys, Daniel Mutnick, Victor Nikulin
  • COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY
    Publication number: 20110245220
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
    Type: Application
    Filed: October 1, 2010
    Publication date: October 6, 2011
    Applicant: IRM LLC
    Inventors: Mihai Azimioara, Christopher Cow, Robert Epple, Gerald Lelais, John Mecom, Victor Nikulin
  • COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY
    Publication number: 20110224185
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
    Type: Application
    Filed: May 23, 2011
    Publication date: September 15, 2011
    Inventors: Phillip B. Alper, Mihai Azimioara, Christopher Cow, Robert Epple, Songchun Jiang, Gerald Lelais, Pierre-Yves Michellys, Daniel Mutnick, Victor Nikulin, Lucas Westcott-Baker
  • 4-PHENOXYMETHYLPIPERIDINES AS MODULATORS OF GPR119 ACTIVITY
    Publication number: 20110190298
    Abstract: The present invention provides compounds of Formula I, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent; diseases or disorders associated with the activity of GPR119.
    Type: Application
    Filed: July 9, 2009
    Publication date: August 4, 2011
    Applicant: IRM LLC
    Inventors: Robert Epple, Gerald Lelais, Victor Nikulin
  • COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY
    Publication number: 20110172244
    Abstract: The invention provides compounds, of Formula I: pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
    Type: Application
    Filed: February 20, 2009
    Publication date: July 14, 2011
    Applicant: IRM LLC
    Inventors: Phillip B. Alper, Robert Epple, Pierre-Yves Michellys, Daniel Mutnick, Victor Nikulin
  • Compounds and compositions as protein kinase inhbitors
    Patent number: 7846923
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, Bcr-Abl(T315I), ALK, BLK, BMX, BRK, C-kit, c-RAF, CSK, c-SRC, EGFR, Fes, FGFR3, Flt3, Fms, Fyn, IGF-1R, IR, JAK(2), JAK(3), KDR, Lck, NLK, p70S6K, PDGFR?, Ros, SAPK2?, SGK, SIK, Syk, Tie2 and TrkB kinases.
    Type: Grant
    Filed: May 11, 2007
    Date of Patent: December 7, 2010
    Assignee: IRM LLC
    Inventors: Pingda Ren, Baogen Wu, Guobao Zhang, Yongping Xie, Barun Okram, Victor Nikulin, Xia Wang, Ha-Soon Choi
  • Substituted tetrahydroisoquinoline compounds, methods of making, and their use
    Patent number: 7718672
    Abstract: Disclosed are novel substituted tetrahydroisoquinoline compounds, pharmaceutical compositions containing the compounds, methods of making the compounds, and methods of using the compounds to destroy a target cell, such as a cancer cell, and to treat or prevent a cancerous condition.
    Type: Grant
    Filed: July 9, 2007
    Date of Patent: May 18, 2010
    Assignee: University of Tennessee Research Foundation
    Inventors: Duane D. Miller, Eldon E. Geisert, Jr., Michael Mohler, Victor Nikulin, Oleg Kirichenko, Seoung Sung Hong, Gyong Suk Kang, Igor Rakov
  • COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHBITORS
    Publication number: 20100048552
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, Bcr-Abl(T315I), ALK, BLK, BMX, BRK, C-kit, c-RAF, CSK, c-SRC, EGFR, Fes, FGFR3, Flt3, Fms, Fyn, IGF-1R, IR, JAK(2), JAK(3), KDR, Lck, NLK, p70S6K, PDGFR?, Ros, SAPK2?, SGK, SIK, Syk, Tie2 and TrkB kinases.
    Type: Application
    Filed: May 11, 2007
    Publication date: February 25, 2010
    Applicant: IRM LLC
    Inventors: Pingda Ren, Baogen Wu, Guobao Zhang, Yongping Xie, Barun Okram, Victor Nikulin, Xia Wang, Ha-Soon Choi
  • COMPOUNDS AND METHODS FOR MODULATING G PROTEIN-COUPLED RECEPTORS
    Publication number: 20100035944
    Abstract: The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating G protein-coupled receptor 20 (GPR20), and methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated GPR20.
    Type: Application
    Filed: January 8, 2008
    Publication date: February 11, 2010
    Applicant: IRM LLC
    Inventors: Robert Epple, Mihal Azimioara, Christopher Cow, Ross Russo, Victor Nikulin, Gerald Lelais
  • THIAZOLE DERIVATIVES AS MODULATORS OF G PROTEIN-COUPLED RECEPTORS
    Publication number: 20100022592
    Abstract: The invention provides compounds of formula (IA) or (IB) and pharmaceutical compositions thereof, which are useful for modulating G protein-coupled receptor 120 (GPR120), and methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated GPR120.
    Type: Application
    Filed: January 7, 2008
    Publication date: January 28, 2010
    Applicant: IRM LLC
    Inventors: Robert Epple, Mihai Azimioara, Christopher Cow, Ross Russo, Victor Nikulin, Gerald Lelais
  • COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY
    Publication number: 20090270409
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
    Type: Application
    Filed: September 4, 2008
    Publication date: October 29, 2009
    Applicant: IRM LLC
    Inventors: Phillip B. Alper, Mihai Azimioara, Christopher Cow, Robert Epple, Songchun Jiang, Gerald Lelais, Pierre-Yves Michellys, Daniel Mutnick, Victor Nikulin, Lucas Westcott-Baker
  • SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS, METHODS OF MAKING, AND THEIR USE
    Publication number: 20070270460
    Abstract: Disclosed are novel substituted tetrahydroisoquinoline compounds, pharmaceutical compositions containing the compounds, methods of making the compounds, and methods of using the compounds to destroy a target cell, such as a cancer cell, and to treat or prevent a cancerous condition.
    Type: Application
    Filed: July 9, 2007
    Publication date: November 22, 2007
    Inventors: Duane Miller, Eldon Geisert, Michael Mohler, Victor Nikulin, Oleg Kirichenko, Seoung Hong, Gyong Kang, Igor Rakov
  • Substituted tetrahydroisoquinoline compounds, methods of making, and their use
    Patent number: 7241774
    Abstract: The present invention relates to novel substituted tetrahydroisoquinoline compounds, pharmaceutical compositions containing the compounds, methods of making the compounds, and methods of using the compounds to destroy a target cell, such as a cancer cell, and to treat or prevent a cancerous condition.
    Type: Grant
    Filed: March 13, 2003
    Date of Patent: July 10, 2007
    Assignee: University of Tennessee Research Foundation
    Inventors: Duane D. Miller, Eldon E. Geisert, Jr., Michael Mohler, Victor Nikulin, Oleg Kirichenko, Seoung Sung Hong, Gyong Suk Kang, Igor Rakov
  • Substituted tetrahydroisoquinoline compounds, methods of making, and their use
    Publication number: 20040019078
    Abstract: The present invention relates to novel substituted tetrahydroisoquinoline compounds, pharmaceutical compositions containing the compounds, methods of making the compounds, and methods of using the compounds to destroy a target cell, such as a cancer cell, and to treat or prevent a cancerous condition.
    Type: Application
    Filed: March 13, 2003
    Publication date: January 29, 2004
    Inventors: Duane D. Miller, Eldon E. Geisert, Michael Mohler, Victor Nikulin, Oleg Kirichenko, Seoung Sung Hong, Gyong Suk Kang, Igor Rakov