Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: Sensors and systems are provided. A sensor as disclosed includes a plurality of pixels disposed within an array. Each pixel is associated with a hyperspectral filter including a metamaterial and a metal grating capable of passing light of a particular wavelength range through to an image sensor. Systems include the use of an aluminum grating separated from a metamaterial including TiO2 and Si3N4 by a SiO2 coupling layer as a filter mounted on a substrate.

Abstract: A microlens array includes a bottom electrode chip, a sidewall electrode chip, and a top glass chip configured to cooperate to define an array of cavities, each one of the array of cavities containing a fluid. The fluid is a mixture of a polar liquid and a non-polar liquid, in contact with one of the array of sidewalls at a contact angle. The bottom electrode chip includes a plurality of electrical contacts. The sidewall electrode chip includes an array of sidewalls, each including an electrode layer and an insulator layer. When a voltage is applied across the fluid contained a cavity via electrical contacts and the electrode layer of the cavity, the contact angle of the fluid with the sidewall is modified, in embodiments without affecting the contact angle of fluid contained in other ones of the plurality of array of cavities.

Abstract: Paraffin-embedded tissue, which may be disposed on a solid substrate, is prepared by a dry technique that removes paraffin from tissue without adding any liquid to the tissue, thereby rendering the tissue substantially free of paraffin. The dry technique may entail applying heat energy to the tissue effective to melt the paraffin and thereby render it flowable, and applying an electric field. The electric field is effective to impart electrical charge to the paraffin and to move the paraffin out from the tissue due to electrical charge repulsion or attraction, which may be assisted by moving an electrode utilized to generate the electric field relative to the paraffin. The electric field, or both the electric field and the heat energy, may be applied until the tissue is substantially free of paraffin.

Abstract: The present disclosure relates optical imaging devices and methods useful in biological and medical imaging applications. In one embodiment, an optical imaging device includes a flexible lightguide having a first end and a second end, the output of the source of pulsed infrared radiation being optically coupled to the first end of the flexible lightguide; a lens assembly attached to and optically coupled to the second end of the flexible lightguide, the lens assembly comprising a variable-focus lens element, the a variable-focus lens element having a tunable focal length; and a photodetector coupled to the flexible lightguide to detect radiation propagating from the second end toward the first end of the flexible lightguide. The optical imaging devices and methods can be used in both confocal and multi-photon techniques.

Abstract: A quantum communications system may include a transmitter node, a receiver node, and a quantum communications channel coupling the transmitter node and receiver node. The transmitter node may include a pulse transmitter, a pulse divider downstream from the pulse transmitter, and at least one first waveplate upstream from the pulse divider and configured to alter a polarization state of pulses travelling therethrough. The receiver node may include at least one second waveplate being a conjugate of the at least one first waveplate, a pulse recombiner upstream from the at least one second waveplate, and a pulse receiver downstream from the at least one second waveplate.

Abstract: One example includes a power supply system. The system includes a voltage-limit power regulator to generate an output voltage and an instantaneous overvoltage sensor configured to detect an overvoltage condition associated with the output voltage. The system further includes an overvoltage latch-off timer system configured to initiate a latch-off timer in response to detecting the overvoltage condition. The latch-off timer can be uninterrupted by an amplitude of the output voltage. The overvoltage latch-off timer system can further be configured to detect a persistent overvoltage fault in response to detecting the overvoltage condition after expiration of the latch-off timer. The overvoltage latch-off timer system can be configured to generate a fault signal to disable the voltage-limit power regulator in response to detecting the persistent overvoltage fault.

Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such data in the conduct of an assay by an assay system. The present invention also relates to consumables (e.g., kits and reagent containers), software, data deployable bundles, computer-readable media, loading carts, instruments, systems, and methods, for performing automated biological assays.

Abstract: An electronic device may be provided with peripheral conductive housing structures, a first antenna, and a second antenna. A gap may divide the housing structures into a first segment forming an arm of the first antenna and a second segment forming an arm of the second antenna. A first feed terminal may be coupled to the first segment and a second feed terminal may be coupled to the second segment. Switchable components may be coupled in parallel between the first and second feed terminals across the gap. The switchable components may be adjusted to tune the frequency response of the first and/or second antenna. The switchable components may have a first state in which only the first feed terminal feeds the first antenna and may have a second state in which both the first and second feed terminals feed the first antenna.

Abstract: Techniques are provided for vision-based altitude estimation using one or more platform mounted cameras. An embodiment includes generating projected ground imagery of imagery provided by cameras of the platform, the projection based on a hypothesized altitude. The method also includes obtaining reference ground imagery based on the location of the platform, the location based on platform navigation data. The method further includes registering the projected ground imagery to the reference ground imagery and generating a match score associated with the registration. The method further includes selecting the hypothesized altitude as the estimated altitude based on the match score (e.g., if the match score exceeds a threshold value or is maximized over a set of hypothesized altitudes.

Abstract: A gaming system configured to perform operations that include receiving, electronically, a first coded identifier, and providing, for presentation, on a display device of a mobile device, the first coded identifier for detection by a wagering game machine. The operations can further include detecting a second coded identifier presented by the wagering game machine after the detection by the wagering game machine of the first coded identifier. The second coded identifier is captured by an image capture device associated with the gaming system. The operations can further include transmitting, electronically, the second coded identifier.

Abstract: In some embodiments, in a system comprising a wagering game machine, the wagering gaming machine including a digital camera and a barcode recognition unit, a method includes: detecting, by the digital camera, a barcode within a field of view of the digital camera and capturing a picture of the barcode; via the barcode recognition unit, decoding the barcode to produce decoded barcode data; in response to the decoded barcode data representing a desired casino wagering game, determining whether the desired casino wagering game is installed on the wagering game machine; and, if the desired casino wagering game is installed on the wagering game machine, loading, initiating and presenting the desired casino wagering game on an electronic display device of the wagering game machine.

Abstract: In one aspect of the present disclosure, a method is provided for operating a vehicle system comprising a motor, a battery, and a controller. The vehicle system is configured to provide at least one of regenerative braking wherein the motor operates to charge the battery and propulsion wherein the motor uses electrical power from the battery to propel the vehicle. The method includes, at the controller, determining an effective motor power at a motor speed and a motor torque. The effective motor power is determined based at least in part on a calculated motor power and an electrical power loss of the motor corresponding to the motor speed and the motor torque. The method further includes causing the motor to apply the motor torque to a wheel of the vehicle upon the effective motor power satisfying an operating condition of the vehicle system.

Abstract: Described are coated food products having a sugar (sucrose) coating, the coating exhibiting desirable levels of sucrose crystallinity and a desired sucrose ratio (total sucrose per total soluble solids), as well as methods or preparing such coated food products and coating.

Abstract: In some embodiments, a method includes: requesting, from a player at the gaming machine, player account credentials associated with the player; receiving, at the gaming machine, the player account credentials, wherein the player account credentials are associated with a player's account on the account server and enable linking game play on the gaming machine to the player's account, and wherein the player account credentials are provided to the player's mobile phone in response to joining a players club prior to detection of the initiation event; transmitting, via the gaming machine, the player account credentials to the account server; receiving, from the account server, validation of the player account credentials based on comparing the received player account credentials with credentials stored on the account server; upon receipt of the validation, linking a wagering game session on the gaming machine with the player account.

Abstract: Disclosed are improved sugar coatings for topically pre-sweetened food products that are sugar reduced whether in the form of a syrup or in the form of a dried coating. The syrup form is useful as an intermediate product in the preparation of pre-sweetened food products. In dry form, the present formulations can be a component part of a composite food product especially in the form of a topical coating or filling. The present invention is particularly suited for the preparation of R-T-E pre-sweetened cereals. The coating formulations comprise less than 70% sucrose, corn syrup and 1-20% non-hydrated integrated starch and preferably about 5-10% insoluble mineral salts each of particle size of about 50 microns.

Abstract: Techniques are provided for vision-based altitude estimation using one or more platform mounted cameras. An embodiment includes generating projected ground imagery of imagery provided by cameras of the platform, the projection based on a hypothesized altitude. The method also includes obtaining reference ground imagery based on the location of the platform, the location based on platform navigation data. The method further includes registering the projected ground imagery to the reference ground imagery and generating a match score associated with the registration. The method further includes selecting the hypothesized altitude as the estimated altitude based on the match score (e.g., if the match score exceeds a threshold value or is maximized over a set of hypothesized altitudes.