Abstract: Methods and systems for topology-based clinical data mining are provided. An example system includes a pre-processing module to process the clinical datasets to generate a table of outcomes and a table of predictors of trial subjects. The system includes a graph construction module to generate metric graphs based on the table of outcomes. The metric graphs include nodes representing the subjects and edges selectively connecting the nodes according to pre-determined criteria. The graph construction module may select a graph of interest from the metric graphs and generate a compressed version of the graph of interest. The system may further include an interactive visualization module to display a graphical representation of the graph of interest or the compressed version, receive selection of groups of the trial subjects, automatically highlight groups of related subjects, and perform, using the table of predictors, a statistical analysis of predictors of subjects within the selected groups.

Abstract: Methods and systems for topology-based clinical data mining are provided. An example system includes a pre-processing module to process the clinical datasets to generate a table of outcomes and a table of predictors of trial subjects. The system includes a graph construction module to generate metric graphs based on the table of outcomes. The metric graphs include nodes representing the subjects and edges selectively connecting the nodes according to pre-determined criteria. The graph construction module may select a graph of interest from the metric graphs and generate a compressed version of the graph of interest. The system may further include an interactive visualization module to display a graphical representation of the graph of interest or the compressed version, receive selection of groups of the trial subjects, automatically highlight groups of related subjects, and perform, using the table of predictors, a statistical analysis of predictors of subjects within the selected groups.