Abstract: Methods and systems for measuring the concentration of LAL-reactive substances in fluid samples is provided. They include contacting an aqueous sample with a detection reagent to form a prepared sample. A physical property of the prepared sample may be measured to obtain at least one sample measurement characteristic of the prepared sample. Curve fitting may then be used to forecast a concentration of the LAL-reactive substance the aqueous sample will have at a specified time in the future based on the sample measurement and a correlation developed between at least one standard measurement of a physical quality of a solution with a known concentration of a LAL-reactive substance therein. The quality of the sample measurement may be validated using historical data and/or the standard measurement.

Abstract: Methods and systems for measuring the concentration of LAL-reactive substances in fluid samples is provided. They include contacting an aqueous sample with a detection reagent to form a prepared sample. A physical property of the prepared sample may be measured to obtain at least one sample measurement characteristic of the prepared sample. Curve fitting may then be used to forecast a concentration of the LAL-reactive substance the aqueous sample will have at a specified time in the future based on the sample measurement and a correlation developed between at least one standard measurement of a physical quality of a solution with a known concentration of a LAL-reactive substance therein. The quality of the sample measurement may be validated using historical data and/or the standard measurement.

Abstract: Methods and systems for measuring the concentration of LAL-reactive substances in fluid samples is provided. They include contacting an aqueous sample with a detection reagent to form a prepared sample. A physical property of the prepared sample may be measured to obtain at least one sample measurement characteristic of the prepared sample. Curve fitting may then be used to forecast a concentration of the LAL-reactive substance the aqueous sample will have at a specified time in the future based on the sample measurement and a correlation developed between at least one standard measurement of a physical quality of a solution with a known concentration of a LAL-reactive substance therein. The quality of the sample measurement may be validated using historical data and/or the standard measurement.

Abstract: A microfluidic testing cartridge for testing LAL-reactive substances in fluid samples is provided. The cartridge may include at least two (2) testing modules, wherein each testing module includes at least one inlet port for receiving one of the fluid samples, and at least four (4) testing channels in fluid communication with the inlet port. Each of the testing channels may include a metering portion for metering an aliquot of the fluid sample, an analyzing portion, and a mixing portion, wherein a valve is positioned between the metering portion and the analyzing portion to selectively fluidly separate the metering portion from the analyzing portion. The cartridge is insertable into an optical reader which performs optical measurements of the fluid sample within each testing channel during a testing process.

Abstract: A microfluidic testing cartridge for testing LAL-reactive substances in fluid samples is provided. The cartridge may comprise at least two (2) testing modules, wherein each testing module includes at least one inlet port for receiving one of the fluid samples, and at least four (4) testing channels in fluid communication with the inlet port. Each of the testing channels may include a metering portion for metering an aliquot of the fluid sample, an analyzing portion, and a mixing portion, wherein a valve is positioned between the metering portion and the analyzing portion to selectively fluidly separate the metering portion from the analyzing portion. The cartridge is insertable into an optical reader which performs optical measurements of the fluid sample within each test ing channel during a testing process.

Abstract: Methods and systems for measuring the concentration of LAL-reactive substances in fluid samples is provided. They include contacting an aqueous sample with a detection reagent to form a prepared sample. A physical property of the prepared sample may be measured to obtain at least one sample measurement characteristic of the prepared sample. Curve fitting may then be used to forecast a concentration of the LAL-reactive substance the aqueous sample will have at a specified time in the future based on the sample measurement and a correlation developed between at least one standard measurement of a physical quality of a solution with a known concentration of a LAL-reactive substance therein. The quality of the sample measurement may be validated using historical data and/or the standard measurement.

Abstract: Methods are provided for improving the stability and shelf life of film sensors. The film sensors include a combination of polymeric matrix film material, analyte indicator, and solvent which has been heated in a first heat treatment application to volatilize most of the solvent and to solidify the analyte indicator to form the film sensor. The improvement comprises subjecting the film sensor to a second heat treatment to set the film and improve stability and shelf life.

Abstract: A multiple-component sensor film includes a carrier polymer matrix and film reactants dispersed within the carrier polymer matrix. The carrier polymer matrix includes a carrier polymer, which includes hydroxypropyl cellulose polymer and the film reactants include an indicator and a reactant from the group of a buffer, a stabilizer, a masking agent, a solubilizer and an internal reference dye. Methods for making the multiple-component sensor film and methods for monitoring the concentration of water soluble polymers in aqueous media are also provided.

Abstract: The present invention discloses a thin reagent containing film sensor for detecting and measuring free chlorine in water, where components of the film sensor are a polymeric substrate that contains reactive material, an organic polyhydroxy compound, a reagent that creates an associated polymeric matrix, and an indicator; and a method for making the same. The film sensor can be formed to fit a specific dimension or shape. The film sensor swells or dissolves when exposed to aqueous solutions so that said reagent is released so that it can react with free chlorine, or the film sensor swells when exposed to aqueous solutions so that the aqueous solution diffuses into the film sensor and reacts with said reagent contained within the swollen film sensor.

Abstract: An adsorbent which selectively binds to one enantiomer of an optically active amino acid or peptide. The adsorbent includes a polymer matrix which contains one or more metal complexes that are oriented within the polymer matrix by molecular imprinting to provide selective binding of the matrix to only one enantiomer of the optically active amino acid or peptide. Separation systems are disclosed which use the adsorbent as the basis for conducting enantioresolution of optically active amino acids and peptides. Methods for using the adsorbent are also disclosed.