Patents by Inventor Vijay Kumar Handa

Vijay Kumar Handa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing florfenicol
    Patent number: 7126005
    Abstract: The present invention is directed to a new process of preparing highly pure Florfenicol. The invention is further directed to new oxazolidine derivatives useful in making Florfenicol and processes of making these derivatives. Examples of such intermediates include (4R,5R)-3-acetyl-2,2-dimethyl-4-hydroxymethyl-5-[4-(methylsulfonyl)phenyl]-1,3-oxazolidine; and (4S,5R)-3-acetyl-2,2-dimethyl-4-fluoromethyl-5-[4-(methylsulfonyl)phenyl]-1,3-oxazolidine.
    Type: Grant
    Filed: December 16, 2003
    Date of Patent: October 24, 2006
    Assignee: Aurobindo Pharma Limited
    Inventors: Vijay Kumar Handa, Arun Kumar Gupta, Meenakshisunderam Sivakumaran
  • Process for preparing 1-methyl-3-phenylpiperazine using a novel intermediate
    Patent number: 7041826
    Abstract: The present invention describes an industrially advantageous process to prepare highly pure 1-Methyl-3-phenylpiperazine of Formula I that makes use of a novel piperazine derivative, 4-Benzyl-1-methyl-2-oxo-3-phenylpiperazine, represented by Formula II 1-Methyl-3-phenylpiperazine is a useful intermediate in the preparation of antidepressant Mirtazapine.
    Type: Grant
    Filed: August 26, 2003
    Date of Patent: May 9, 2006
    Assignee: Aurobindo Pharma Ltd.
    Inventors: Vijay Kumar Handa, Divvela Venkata Naga Srinivasa Rao, Meenakshisunderam Sivakumaran
  • Process for the preparation of highly pure crystalline (R,S)—cefuroxime axetil
    Patent number: 6833452
    Abstract: A process for the preparation of highly pure crystalline form of cefuroxime-1-acetoxyethyl ester (cefuroxime axetil) from cefuroxime by reacting an amine salt of cefuroxime with an esterifying reagent.
    Type: Grant
    Filed: July 16, 2001
    Date of Patent: December 21, 2004
    Assignee: Ranbaxy Laboratories Limited
    Inventors: Om Dutt Tyagi, Gyan Chand Yadav, Vijay Kumar Handa
  • Process for preparing 1-methyl-3-phenylpiperazine using a novel intermediate
    Publication number: 20040242879
    Abstract: The present invention describes an industrially advantageous process to prepare highly pure 1-Methyl-3-phenylpiperazine of Formula I 1
    Type: Application
    Filed: August 26, 2003
    Publication date: December 2, 2004
    Inventors: Vijay Kumar Handa, Divvela Venkata Naga Srinivasa Rao, Meenakshisunderam Sivakumaran
  • Preparation of pure citalopram
    Patent number: 6781003
    Abstract: The present invention relates to an industrially advantageous method for the purification of Citalopram (Formula I) wherein desmethyl citalopram (Formula II), present in crude Citalopram as an impurity, is methylated to produce pure Citalopram.
    Type: Grant
    Filed: June 9, 2003
    Date of Patent: August 24, 2004
    Assignee: Aurobindo Pharma Ltd.
    Inventors: Vipin Kumar Kaushik, Divvela Venkata Naga Srinivasa Rao, Vijay Kumar Handa, Meenakshisunderam Sivakumaran
  • Process for the preparation of furaca
    Patent number: 6476220
    Abstract: A process is disclosed for the preparation of 7-amino-3-(2-furanylcarbonylthiomethyl)-3-cephem-4-carboxylic acid (also known as Furaca). The process comprises of the steps of reacting 7-aminocephalosporanic acid with a mixture of 2-thiofuric acid and Boron Trifluoride in a solvent and precipitating Furaca as a solid.
    Type: Grant
    Filed: July 9, 2001
    Date of Patent: November 5, 2002
    Assignee: Aurobindo Pharma Limited
    Inventors: Uthira Kumar, Meenakshisunderam Sivakumaran, Vijay Kumar Handa
  • Ceftiofur, its intermediate and a process for the preparation of the same
    Patent number: 6458949
    Abstract: A novel process for the preparation of ceftiofur, a cephalosporin antibiotic useful in the treatment of bovine respiratory disease using a novel bromo or chloro intermediate. the process comprises of the steps of cyclizing a new bromo or chloro intermediate with thiourea in the presence of selected solvents to produce ceftiofur of high purity. A process to prepare such novel bromo and chloro intermediate comprising of the steps of condensing silylated Furaca with 4-(bromo or chloro)-2 methoxyamino-3-oxobutyric acid or its acid halide is also described.
    Type: Grant
    Filed: July 9, 2001
    Date of Patent: October 1, 2002
    Assignee: Aurobindo Pharma Limited
    Inventors: Vijay Kumar Handa, Meenakshisunderam Sivakumaran, Ramesh Dandala, Venkataiah Sunku
  • Cephalosporin compound and a process for its preparation
    Publication number: 20020065412
    Abstract: A process is disclosed for the preparation of 7-amino-3-(2-furanylcarbonylthiomethyl)-3-cephem-4-carboxylic acid of the formula 1
    Type: Application
    Filed: July 9, 2001
    Publication date: May 30, 2002
    Inventors: Uthira Kumar, Meenakshisunderam Sivakumaran, Vijay Kumar Handa
  • Process for preparing a pure, pharmacopoeial grade amorphous form of cefuroxime axetil
    Patent number: 6384213
    Abstract: There is described a process for the preparation of a pure amorphous form of cefuroxime axetil which involves dissolving crystalline cefuroxime axetil in acetic acid including at least 5% v/v water and recovering said amorphous form of cefuroxime axetil from the solution by the addition of additional water, the solution being added all at once to the additional water being present in a volume which is sufficient to precipitate said amorphous cefuroxime axetil.
    Type: Grant
    Filed: May 19, 2000
    Date of Patent: May 7, 2002
    Assignee: Ranbaxy Laboratories Limited
    Inventors: Vijay Kumar Handa, Om Dutt Tyagi, Uttam Kumar Ray
  • Ceftiofur, its intermediate and a process for the preparation of the same
    Publication number: 20020028931
    Abstract: A novel process for the preparation of ceftiofur, a cephalosporin antibiotic useful in the treatment of bovine respiratory disease. The process utilizes a new bromo or chloro intermediate that can be isolated in a pure form by this inventive process subsequently resulting in ceftiofur of high purity. This invention offers a new-to-the-world route to Ceftiofur using novel intermediates.
    Type: Application
    Filed: July 9, 2001
    Publication date: March 7, 2002
    Inventors: Ramesh Dandala, Venkataiah Sunku, Vijay Kumar Handa, Meenakshisunderam Sivakumaran
  • Process for the preparation of highly pure crystalline (R,S) - cefuroxime axetil
    Publication number: 20020016456
    Abstract: A process for the preparation of highly pure crystalline form of cefuroxime-1-acetoxyethyl ester (cefuroxime axetil) from cefuroxime by reacting an amine salt of cefuroxime with an esterifying reagent.
    Type: Application
    Filed: July 16, 2001
    Publication date: February 7, 2002
    Inventors: Om Dutt Tyagi, Gyan Chand Yadav, Vijay Kumar Handa
  • Process for the preparation of cefuroxime
    Patent number: 6235896
    Abstract: There is described a process for the preparation of cefuroxime from predominantly S-cefuroxime axetil, R, S mixture of cefuroxime axetil or R-cefuroxime axetil not meeting the purity criteria. This comprises treating cefuroxime axetil with alkoxides in the presence of a suitable solvent or solvent mixture and isolating cefuroxime from the reaction mixture.
    Type: Grant
    Filed: March 9, 1999
    Date of Patent: May 22, 2001
    Assignee: Ranbaxy Laboratories Limited
    Inventors: Vijay Kumar Handa, Ramesh Dandala, Jag Mohan Khanna
  • Process for the preparation of crystalline (Z)-2-(2-tert.-butoxycarbonylprop-2-oxyimino)-2-(2-triphenylmethylaminothiazol-4-yl) acetic acid in association with N,N-dimethylformamide
    Patent number: 6214997
    Abstract: The present invention relates to the preparation of crystalline (Z)-2-(2-tert.-butoxycarbonyl prop-2-oxyimino)-2-(2-triphenylmethylaminothiazol-4-yl) acetic acid of the following formula which is useful in the synthesis of &bgr;-lactam antibiotics such is ceftazidime.
    Type: Grant
    Filed: May 27, 1999
    Date of Patent: April 10, 2001
    Assignee: Ranbaxy Laboratories Limited
    Inventors: Vijay Kumar Handa, Surinder Mohan Gupta, Nittin Maheshwari, Amit Rohatgi
  • Process for producing cephalosporin antibiotics
    Patent number: 5869649
    Abstract: A process for preparing certain cephalosporin antibiotics, namely, cefotaxime, cefetemet, and ceftriaxone sodium comprising acylation of 7-amino-3-cephem-4-carboxylic acid derivatives with 2-mercapto-5-methyl-1,3,4-thiadiazolyl-(Z)-2-(2-aminothiazol-4-yl)-2-metho xyiminoacetate having the formula: ##STR1##
    Type: Grant
    Filed: May 1, 1996
    Date of Patent: February 9, 1999
    Assignee: Ranbaxy Laboratories Ltd.
    Inventors: Jag Mohan Khanna, Vijay Kumar Handa, Ramesh Dandala, Ram Chander Aryan