Abstract: Nitrofurantoin particulates comprising discrete particulates of nitrofurantoin wherein:(a) said particulates are larger than about 200 mesh size; and(b) the BET surface area of said particulates is at least about 0.2 M.sup.2 /g.Preferably, the surface of said particulates consists essentially of nitrofurantoin monohydrate. Also preferably, said particulates comprise at least about 5%, more preferably at least about 50% of nitrofurantoin monohydrate. Preferred compositions of this invention comprise these nitrofurantoin particulates in an aqueous suspension. The nitrofurantoin particulates of this invention are highly efficacious for the delivery of nitrofurantoin in oral dosage forms.

Abstract: Compositions, for the administration of nitrofurantoin to a human or other animal subject, comprising:(a) a safe and effective amount of nitrofurantoin particulates having a surface consisting of nitrofurantoin monohydrate, wherein said particulates have a mean particle size greater than about 200 mesh size;(b) nitrofurantoin monohydrate;(c) an effective amount of a suspending agent; and(d) water;wherein the pH of said composition is from about 1 to about 6; and said nitrofurantoin monohydrate is dissolved in said water at saturation level. The nitrofurantoin of this invention are highly efficacious for the oral delivery of nitrofurantoin.