Abstract: Compounds, useful as protease inhibitors, of the formula (I): where: Ar is a ring or ring system, for example a benzene ring, and may be substituted by one or more moieties in addition to X and LJ; X is a functional group which is a hydrogen-bond acceptor, e.g. a nitro or boronate group BY1Y2; L is a linker, most preferably (CR5R6)—S—; J is a moiety containing a basic nitrogen atom but not containing an amino acid residue, preferably amidino, guanidine, amino carboxamido, hydroxylamino, or imidazolyl, or an N-substituted analogue thereof.

Abstract: Products which contain two interlinked functional moieties of which one is an integrin-binding protein (e.g. a snake venom protein) or a homologue thereof. The products comprise a first portion which is an integrin-binding protein, a homologue thereof having a binding activity or a fragment of either which has integrin-binding activity, and, ligated to the first portion, a second portion which has a different function.

Abstract: The use of dendroaspin as a scaffold for one or more non-wild-type dendroaspin domains, the dendroaspin scaffold being modified in that the native RGD motif has been deleted or has been replaced by (i) an amino acid sequence having no integrin-binding activity or (ii) an integrin-binding amino acid sequence other than RGD which contains aspartic acid (D) or glutamic acid (E).

Abstract: Peptides which act as inhibitors or substrates of thrombin are provided.

Abstract: This invention is directed to peptide inhibitors of serine proteases, espcecially thrombin, in which the P1-P2 natural amide linkage is replaced by another bond. Exemplary thrombin inhibitors have the formula: X-(aa.sup.3)-(aa.sup.2)-.psi.-(aa.sup.1)-Z wherein X is H or a substituent on the N-terminal amino group, aa.sup.3 is a hydrophobic amino acid, aa.sup.23 is Pro, aa.sup.1 is Arg or an Arg analgoue, Z is --COOH or a heteroatom acid group and .psi. is a non-amide linkage.

Abstract: This invention provides peptides of the formula ##STR1## wherein X is H, CH.sub.3 or an N-protecting group;Y is(1) C.sub.3 -C.sub.9 alkyl optionally substituted by C.sub.1 -C.sub.4 alkoxy,(2) C.sub.5 -C.sub.10 aryl optionally substituted by C.sub.1 -C.sub.4 alkoxy,(3) C.sub.5 -C.sub.10 alkylaryl optionally substituted by C.sub.1 -C.sub.4 alkoxy,(4) (CH.sub.2).sub.n --Q or ##STR2## wherein Q is H, amino, amidino, imidizole, guanidino or isothioureido and n is 1-5;Z is COR.sub.1, ##STR3## wherein: R.sub.1 is H, OH, CH.sub.2 Cl, CH.sub.2 --CH.sub.2 --CO-pip, CF.sub.2 --CF.sub.2 --CO-pip, CH.sub.2 --CH(CH.sub.3)--CO-pip, CF.sub.2 --CF(CF.sub.3)--CO-pip, CH.sub.2 --CH.sub.2 --CO-Pro-NHEt, CF.sub.2 --CF.sub.2 --CO-Pro-NHEt or a chromophoric group,R.sub.2 and R.sub.3 may be the same or different and are selected from the group consisting of OH, OR.sub.6 and NR.sub.6 R.sub.7, wherein R.sub.6 and R.sub.7 may be the same or different and are selected from the group consisting of C.sub.1-10 alkyl, phenyl or C.sub.6 -C.

Abstract: Peptides which act as inhibitors or substrates of thrombin are derived from the formula: D-Phe-Pro-Arg or its analogues, wherein Phe is substituted by (a), wherein Ar.sub.1 or Ar.sub.2 are the same or different and are selected from the group consisting of phenyl, thienyl, pyridyl, naphthyl, thionaphtyl, indolyl and saturated groups corresponding to these, optionally substituted by up to three groups selected from C.sub.1 -C.sub.3 alkyl and C.sub.1 -C.sub.3 alkoxy, L.sub.1 and L.sub.2 are the same of different and are selected from the group consisting of CH.sub.2, C.sub.2 --C.sub.2, O-CH.sub.2, S-CH.sub.2, Ar-L taken together optionally means H, diphenyl-methyl, fluorenyl or saturated groups corresponding to these, but one of the Ar-L cannot be H when the other [CH.sub.2 ].sub.n -Q, (c) where Q=H, amino, amidino, imidazole, guanidino or isothioureido and n=1-5, preferably 3-5, or C.sub.3 -C.sub.9 alkyl and C.sub.5 -C.sub.