Patents by Inventor Vincent Chiang
Vincent Chiang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230333102Abstract: The present invention relates to analyte detection devices and methods of using such devices to detect minute quantities of a target analyte in a sample. In particular, the invention provides a method of detecting a target analyte in a sample comprising mixing the sample with a first detection conjugate and a second detection conjugate in solution, wherein the first and second detection conjugates comprise metallic nanostructures coupled to binding partners that are capable of specifically binding to the target analyte if present in the sample to form a complex between the first detection conjugate, the analyte, and the second detection conjugate, wherein a change in an optical signal upon complex formation indicates the presence of the target analyte in the sample. Methods of preparing nanostructures and nanoalloys, as well as nanostructures and nanoalloys conjugated to binding partners, are also described.Type: ApplicationFiled: February 24, 2023Publication date: October 19, 2023Inventors: Rajesh K. Mehra, Vincent Chiang, Kenneth P. Aron, Jessica Frisz
-
Patent number: 11614447Abstract: The present invention relates to analyte detection devices and methods of using such devices to detect minute quantities of a target analyte in a sample. In particular, the invention provides a method of detecting a target analyte in a sample comprising mixing the sample with a first detection conjugate and a second detection conjugate in solution, wherein the first and second detection conjugates comprise metallic nanostructures coupled to binding partners that are capable of specifically binding to the target analyte if present in the sample to form a complex between the first detection conjugate, the analyte, and the second detection conjugate, wherein a change in an optical signal upon complex formation indicates the presence of the target analyte in the sample. Methods of preparing nanostructures and nanoalloys, as well as nanostructures and nanoalloys conjugated to binding partners, are also described.Type: GrantFiled: November 29, 2021Date of Patent: March 28, 2023Assignee: Zoetis Services LLCInventors: Rajesh K. Mehra, Vincent Chiang, Kenneth Aron, Jessica Frisz
-
Publication number: 20220091113Abstract: The present invention relates to nanostructure-binding partner conjugates, as well as reaction mixtures, analyte detection devices, and methods of making and using the conjugates. In particular, the invention provides a method of detecting a target analyte in a sample comprising mixing the sample with a first detection conjugate and a second detection conjugate in solution, wherein the first and second detection conjugates comprise metallic nanostructures coupled to binding partners that are capable of specifically binding to the target analyte if present in the sample to form a complex between the first detection conjugate, the analyte, and the second detection conjugate, wherein a change in an optical signal upon complex formation indicates the presence of the target analyte in the sample.Type: ApplicationFiled: January 30, 2018Publication date: March 24, 2022Inventors: Rajesh K. MEHRA, Kenneth P. ARON, Vincent CHIANG, Sarah Ann UNSER
-
Publication number: 20220082562Abstract: The present invention relates to analyte detection devices and methods of using such devices to detect minute quantities of a target analyte in a sample. In particular, the invention provides a method of detecting a target analyte in a sample comprising mixing the sample with a first detection conjugate and a second detection conjugate in solution, wherein the first and second detection conjugates comprise metallic nanostructures coupled to binding partners that are capable of specifically binding to the target analyte if present in the sample to form a complex between the first detection conjugate, the analyte, and the second detection conjugate, wherein a change in an optical signal upon complex formation indicates the presence of the target analyte in the sample. Methods of preparing nanostructures and nanoalloys, as well as nanostructures and nanoalloys conjugated to binding partners, are also described.Type: ApplicationFiled: November 29, 2021Publication date: March 17, 2022Inventors: Rajesh K. MEHRA, Vincent CHIANG, Kenneth ARON, Jessica FRISZ
-
Publication number: 20220074934Abstract: The present invention relates to analyte detection devices and methods of using such devices to detect minute quantities of a target analyte in a sample. In particular, the invention provides an analyte detection device comprising a plurality of composite metallic nanostructures conjugated to analyte binding partners and a surface containing a metallic nanolayer on which a plurality of capture molecules is immobilized. Methods of preparing composite nanostructures are also described.Type: ApplicationFiled: November 16, 2021Publication date: March 10, 2022Inventors: Rajesh K. Mehra, Vincent Chiang, Kenneth P. Aron, Asher Krell
-
Patent number: 11215614Abstract: The present invention relates to analyte detection devices and methods of using such devices to detect minute quantities of a target analyte in a sample. In particular, the invention provides a method of detecting a target analyte in a sample comprising mixing the sample with a first detection conjugate and a second detection conjugate in solution, wherein the first and second detection conjugates comprise metallic nanostructures coupled to binding partners that are capable of specifically binding to the target analyte if present in the sample to form a complex between the first detection conjugate, the analyte, and the second detection conjugate, wherein a change in an optical signal upon complex formation indicates the presence of the target analyte in the sample. Methods of preparing nanostructures and nanoalloys, as well as nanostructures and nanoalloys conjugated to binding partners, are also described.Type: GrantFiled: August 20, 2019Date of Patent: January 4, 2022Assignee: Zoetis Services LLCInventors: Rajesh K. Mehra, Vincent Chiang, Kenneth Aron, Jessica Frisz
-
Patent number: 11209430Abstract: The present invention relates to analyte detection devices and methods of using such devices to detect minute quantities of a target analyte in a sample. In particular, the invention provides an analyte detection device comprising a plurality of composite metallic nanostructures conjugated to analyte binding partners and a surface containing a metallic nanolayer on which a plurality of capture molecules is immobilized. Methods of preparing composite nanostructures are also described.Type: GrantFiled: October 16, 2019Date of Patent: December 28, 2021Assignee: ZOETIS SERVICES LLCInventors: Rajesh K. Mehra, Vincent Chiang, Kenneth P. Aron, Asher Krell
-
Publication number: 20200150115Abstract: The present invention relates to analyte detection devices and methods of using such devices to detect minute quantities of a target analyte in a sample. In particular, the invention provides an analyte detection device comprising a plurality of composite metallic nanostructures conjugated to analyte binding partners and a surface containing a metallic nanolayer on which a plurality of capture molecules is immobilized. Methods of preparing composite nanostructures are also described.Type: ApplicationFiled: October 16, 2019Publication date: May 14, 2020Inventors: Rajesh K. MEHRA, Vincent CHIANG, Kenneth P. ARON, Asher KRELL
-
Publication number: 20200110086Abstract: The present invention relates to analyte detection devices and methods of using such devices to detect minute quantities of a target analyte in a sample. In particular, the invention provides a method of detecting a target analyte in a sample comprising mixing the sample with a first detection conjugate and a second detection conjugate in solution, wherein the first and second detection conjugates comprise metallic nanostructures coupled to binding partners that are capable of specifically binding to the target analyte if present in the sample to form a complex between the first detection conjugate, the analyte, and the second detection conjugate, wherein a change in an optical signal upon complex formation indicates the presence of the target analyte in the sample. Methods of preparing nanostructures and nanoalloys, as well as nanostructures and nanoalloys conjugated to binding partners, are also described.Type: ApplicationFiled: August 20, 2019Publication date: April 9, 2020Inventors: Rajesh K. MEHRA, Vincent CHIANG, Kenneth ARON, Jessica FRISZ
-
Patent number: 10488409Abstract: The present invention relates to analyte detection devices and methods of using such devices to detect minute quantities of a target analyte in a sample. In particular, the invention provides an analyte detection device comprising a plurality of composite metallic nanostructures conjugated to analyte binding partners and a surface containing a metallic nanolayer on which a plurality of capture molecules is immobilized. Methods of preparing composite nanostructures are also described.Type: GrantFiled: August 13, 2015Date of Patent: November 26, 2019Assignee: Abaxis, Inc.Inventors: Rajesh K. Mehra, Vincent Chiang, Kenneth P. Aron, Asher Krell
-
Patent number: 10429383Abstract: The present invention relates to analyte detection devices and methods of using such devices to detect minute quantities of a target analyte in a sample. In particular, the invention provides a method of detecting a target analyte in a sample comprising mixing the sample with a first detection conjugate and a second detection conjugate in solution, wherein the first and second detection conjugates comprise metallic nanostructures coupled to binding partners that are capable of specifically binding to the target analyte if present in the sample to form a complex between the first detection conjugate, the analyte, and the second detection conjugate, wherein a change in an optical signal upon complex formation indicates the presence of the target analyte in the sample. Methods of preparing nanostructures and nanoalloys, as well as nanostructures and nanoalloys conjugated to binding partners, are also described.Type: GrantFiled: October 31, 2017Date of Patent: October 1, 2019Assignee: Abaxis, Inc.Inventors: Rajesh Mehra, Vincent Chiang, Kenneth Aron, Jessica Frisz
-
Publication number: 20180059104Abstract: The present invention relates to analyte detection devices and methods of using such devices to detect minute quantities of a target analyte in a sample. In particular, the invention provides a method of detecting a target analyte in a sample comprising mixing the sample with a first detection conjugate and a second detection conjugate in solution, wherein the first and second detection conjugates comprise metallic nanostructures coupled to binding partners that are capable of specifically binding to the target analyte if present in the sample to form a complex between the first detection conjugate, the analyte, and the second detection conjugate, wherein a change in an optical signal upon complex formation indicates the presence of the target analyte in the sample. Methods of preparing nanostructures and nanoalloys, as well as nanostructures and nanoalloys conjugated to binding partners, are also described.Type: ApplicationFiled: October 31, 2017Publication date: March 1, 2018Inventors: Rajesh MEHRA, Vincent CHIANG, Kenneth ARON, Jessica FRISZ
-
Patent number: 9835622Abstract: The present invention relates to analyte detection devices and methods of using such devices to detect minute quantities of a target analyte in a sample. In particular, the invention provides a method of detecting a target analyte in a sample comprising mixing the sample with a first detection conjugate and a second detection conjugate in solution, wherein the first and second detection conjugates comprise metallic nanostructures coupled to binding partners that are capable of specifically binding to the target analyte if present in the sample to form a complex between the first detection conjugate, the analyte, and the second detection conjugate, wherein a change in an optical signal upon complex formation indicates the presence of the target analyte in the sample. Methods of preparing nanostructures and nanoalloys, as well as nanostructures and nanoalloys conjugated to binding partners, are also described.Type: GrantFiled: August 4, 2016Date of Patent: December 5, 2017Assignee: ABAXIS, INC.Inventors: Rajesh Mehra, Vincent Chiang, Kenneth Aron, Jessica Frisz
-
Publication number: 20170038366Abstract: The present invention relates to analyte detection devices and methods of using such devices to detect minute quantities of a target analyte in a sample. In particular, the invention provides a method of detecting a target analyte in a sample comprising mixing the sample with a first detection conjugate and a second detection conjugate in solution, wherein the first and second detection conjugates comprise metallic nanostructures coupled to binding partners that are capable of specifically binding to the target analyte if present in the sample to form a complex between the first detection conjugate, the analyte, and the second detection conjugate, wherein a change in an optical signal upon complex formation indicates the presence of the target analyte in the sample. Methods of preparing nanostructures and nanoalloys, as well as nanostructures and nanoalloys conjugated to binding partners, are also described.Type: ApplicationFiled: August 4, 2016Publication date: February 9, 2017Inventors: Rajesh MEHRA, Vincent CHIANG, Kenneth ARON, Jessica FRISZ
-
Publication number: 20160047804Abstract: The present invention relates to analyte detection devices and methods of using such devices to detect minute quantities of a target analyte in a sample. In particular, the invention provides an analyte detection device comprising a plurality of composite metallic nanostructures conjugated to analyte binding partners and a surface containing a metallic nanolayer on which a plurality of capture molecules is immobilized. Methods of preparing composite nanostructures are also described.Type: ApplicationFiled: August 13, 2015Publication date: February 18, 2016Inventors: Rajesh K. MEHRA, Vincent CHIANG, Kenneth P. ARON, Asher KRELL
-
Patent number: 8673576Abstract: The present invention discloses methods for detecting the presence of a complex between a first reagent and a second reagent in solution. In particular, the invention provides methods for qualitative or quantitative detection of an analyte or its specific binding partner in complex biological samples. The invention further discloses algorithms using summary rate changes at selected wavelengths in the absorbance spectra of colloidal metal-labeled analytes or specific binding partners to identify intermolecular interactions between the analyte and its binding partner.Type: GrantFiled: March 19, 2012Date of Patent: March 18, 2014Assignee: Abaxis, Inc.Inventors: Vincent Chiang, Rajesh K. Mehra
-
Patent number: 8530152Abstract: The present invention discloses methods of reducing non-specific interactions of interfering species present in a sample in metallic nanoparticle-based assays, thereby increasing the sensitivity of these assays. In particular, the methods entail neutralizing the chemical reactivity of functional groups present in interfering species by addition of a neutralizing agent, such as an alkylating agent or heavy metal ion. The methods are especially useful in assays for the detection of analytes in biological samples. Reagent kits and assay mixtures for the practice of the described methods are also disclosed.Type: GrantFiled: July 9, 2009Date of Patent: September 10, 2013Assignee: Abaxis, Inc.Inventors: Rajesh K. Mehra, Vincent Chiang, Kenneth Aron
-
Publication number: 20120252005Abstract: The present invention discloses methods for detecting the presence of a complex between a first reagent and a second reagent in solution. In particular, the invention provides methods for qualitative or quantitative detection of an analyte or its specific binding partner in complex biological samples. The invention further discloses algorithms using summary rate changes at selected wavelengths in the absorbance spectra of colloidal metal-labeled analytes or specific binding partners to identify intermolecular interactions between the analyte and its binding partner.Type: ApplicationFiled: March 19, 2012Publication date: October 4, 2012Applicant: Abaxis, Inc.Inventors: Vincent CHIANG, Rajesh K. Mehra
-
Patent number: 8137920Abstract: The present invention discloses methods for detecting the presence of a complex between a first reagent and a second reagent in solution. In particular, the invention provides methods for qualitative or quantitative detection of an analyte or its specific binding partner in complex biological samples. The invention further discloses algorithms using summary rate changes at selected wavelengths in the absorbance spectra of colloidal metal-labeled analytes or specific binding partners to identify intermolecular interactions between the analyte and its binding partner.Type: GrantFiled: March 18, 2009Date of Patent: March 20, 2012Assignee: Abaxis, Inc.Inventors: Vincent Chiang, Rajesh K. Mehra
-
Publication number: 20100159441Abstract: The present invention discloses methods for detecting the presence of a complex between a first reagent and a second reagent in solution. In particular, the invention provides methods for qualitative or quantitative detection of an analyte or its specific binding partner in complex biological samples. The invention further discloses algorithms using summary rate changes at selected wavelengths in the absorbance spectra of colloidal metal-labeled analytes or specific binding partners to identify intermolecular interactions between the analyte and its binding partner.Type: ApplicationFiled: March 18, 2009Publication date: June 24, 2010Applicant: ABAXIS, INC.Inventors: VINCENT CHIANG, RAJESH K. MEHRA